Results 81 to 90 of about 351,543 (287)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

An FMEA-Based Risk Assessment Approach for Wind Turbine Systems: A Comparative Study of Onshore and Offshore [PDF]

open access: yes, 2014
Failure mode and effects analysis (FMEA) has been extensively used by wind turbine assembly manufacturers for analyzing, evaluating and prioritizing potential/known failure modes.
Shafiee, Mahmood   +5 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Evaluasi Gangguan Jaringan Telepon dengan Kombinasi Metode Fault Tree Analysis dan Failure Mode And Effect Analysis

open access: yesJurnal Ilmiah Teknik Industri, 2017
Evaluation the disruptions of telephone network uses a method fault tree analysis (FTA) and failure mode and effect analysis (FMEA). By using FTA, the fault events are identified, which contribute causing top level event of jarlokat isolation, jarlokaf ...
Andung Jati Nugroho
doaj   +1 more source

Risk Analysis of Five-Axis CNC Water Jet Machining Using Fuzzy Risk Priority Numbers

open access: yesSymmetry
The reliability and safety of five-axis CNC abrasive water jet machining are critical for many industries. This study employs Failure Mode and Effects Analysis (FMEA) to identify and mitigate potential failures in this machining system. Traditional FMEA, which relies on crisp numerical values, often struggles with handling uncertainty in risk ...
Ufuk Cebeci   +2 more
openaire   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Risk Priority With Fuzzy Logic: Application of A Textile Factory

open access: yes, 2019
The most important reality in the businesslife that has not changed in the last fifty years is perhaps the necessity forthe “customer satisfaction to be sustainable.” Every failure that adverselyaffects product quality also causes customer ...
Tülay KORKUSUZ POLAT
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

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