Results 91 to 100 of about 1,380,859 (329)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Multi-criteria decision analysis for benchmarking human-free lifting solutions in the offshorewind energy environment [PDF]

, 2018
With single components weighing up to hundreds of tonnes and lifted to heights of approximately 100 m, offshore wind turbines can pose risks to personnel, assets, and the environment during installation and maintenance interventions.
Balaam, Toby, Brennan, Feargal, Causon, Paul, Cevasco, Debora, Kolios, Athanasios, Leimeister, Mareike, Richmond, Mark   +6 more
core   +4 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Strategy Options for Disaster Risk Reduction Through Institutional Improvements and Enhanced Financial Sustainability: Recommendations [PDF]

This presentation was commissioned by the Natural Disaster Network of the Regional Policy Dialogue for the V Hemispheric Meeting celebrated on June 13th and 14th, 2005.Disasters, Management Network Gestión de la ...
Allan M. Lavell, Omar D. Cardona
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Optimal Decisions for Medical Equipment Remanufacturing Under Carbon Price Fluctuation With Carbon Options

IEEE Access
This study examines the effects of carbon options in hedging against the risk of carbon price fluctuation in a remanufacturing setting. Specifically, we develop an optimization model for a medical equipment enterprise that produces new products in the ...
Rong Fu, Junfei Ding
doaj   +1 more source

Hedging cotton price risk in Francophone African countries [PDF]

Cotton exports account for a significant share of total commodity exports in francophone African countries, suggesting that these countries have a large exposure to volatility in cotton prices.
DEC, Satyanarayan, Sudhakar, Thigpen, Elton, Varangis, Panos   +3 more
core  

Community Knowledge, Perceptions, and Practices Associated with Urogenital Schistosomiasis among School-Aged Children in Zanzibar, United Republic of Tanzania [PDF]

, 2016
Background: On the Zanzibar islands, United Republic of Tanzania, elimination of urogenital schistosomiasis is strived for in the coming years. This qualitative study aimed to better understand community knowledge, perceptions, and practices associated ...
A'Kadir, Faiza M., Ali, Jamal N., Ali, Said M., Knopp, Stefanie, Mohammed, Khalfan A., Mohammed, Ulfat A., Person, Bobbie, Rollinson, David   +7 more
core   +3 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Towards improved public awareness for climate related disaster risk reduction in South Africa: A Participatory Development Communication perspective

Jàmbá, 2009
Southern Africa has frequently been struck by damaging climate hazards which increasingly continue to threaten sustainable development efforts. Ominously, climate models predict that the incidence of major ‘wet’ events, such as floods and cyclones will ...
Tigere Chagutah
doaj   +1 more source