Results 81 to 90 of about 9,368,536 (289)
Digital Public Goods for Disaster Risk Reduction in a Changing Climate
, 2023 The growth of the disaster and climate risk analysis has largely taken place through the development of proprietary models and data only accessible to a restricted group of users. However, core digital assets
Global Facility for Disaster Reduction +1 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
A Multi-Period Model for Optimal Deployment of Cost-Effective Risk Reduction Systems
Chemical Engineering TransactionsReducing safety risk is an important priority for all industrial plants. However, it can be difficult to select a risk management portfolio from a large number of options when there is a constraint on capital expenditure.
Dominic C.Y. Foo, Raymond R. Tan
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
IEEE AccessThis study examines the effects of carbon options in hedging against the risk of carbon price fluctuation in a remanufacturing setting. Specifically, we develop an optimization model for a medical equipment enterprise that produces new products in the ...
Rong Fu, Junfei Ding
doaj +1 more source
HEDGING CROP RISK WITH YIELD INSURANCE FUTURES AND OPTIONS [PDF]
This paper analyses the optimal hedging decisions for risk-averse producers facing crop risk, assuming crop yield insurance futures and options can be used.
Vermersch, Dominique, Mahul, Olivier
core
Constructing a holistic approach to disaster risk reduction: the significance of focusing on vulnerability reduction [PDF]
, 2013 As a result of the increase in natural disaster losses, policy-makers, practitioners, and members of the research community around the world are seeking effective and efficient means of overcoming or minimising them.
Baldry, David +5 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source