Results 101 to 110 of about 9,368,536 (289)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Screening CO2 storage options in The Netherlands [PDF]
, 2009 This paper describes the development and application of a methodology to screen and rank Dutch reservoirs suitable for long-term large scale CO2 storage. The screening focuses on off- and on-shore individual aquifers, gas and oil fields.
Kramers, L. +12 more
core +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2010 In Dion, P. (Ed.). Soil biology and agriculture in the tropics. Heidelberg, Germany: Springer Verlag ; Wastewater irrigation is becoming a global phenomenon, as a result of global water scarcity and increased pollution of water sources. While this practice offers many opportunities, human health risks from contaminated soils and crops irrigated with ...
Abaidoo, Robert C. +4 more
openaire +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
INCORPORATING RISK PREFERENCES INTO REAL OPTIONS MODELS [PDF]
This paper develops a framework to link the expected utility analysis to real options models in order to capture the joint effects of risk aversion and irreversibility associated with real investments.
Isik, Murat
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Use of the event tree to assess the risk reduction obtained from rockfall protection devices [PDF]
Natural Hazards and Earth System Sciences, 2008 The paper presents and discusses a procedure for the evaluation of the collective risk that can affect a road subjected to rockfalls, with and without protection measures, by means of the event tree analysis. This tool is useful to show designers whether
D. Peila, C. Guardini
doaj
Identification of the corporate entities in the practice of financial monitoring
Ученые записки Российской академии предпринимательства, 2021 The article discusses the options for the process of identification of the client as a person engaged in financial transactions, methods of identifying beneficial owners, which allows the credit institution to implement measures of due diligence of ...
S. S. Gamonenko
doaj