Results 71 to 80 of about 3,593,757 (358)

Ten Years Risk Prediction of a Major Cardiovascular Event in a Rural Block in Tamil Nadu

Heart India, 2015
Background: India has a high burden of cardiovascular diseases (CVDs). High-risk interventions can be initiated only when individuals at high-risk have been identified.
Logaraj Muthunarayanan, John Kamala Russel, Shailendra Kumar Hegde, Balaji Ramraj   +3 more
doaj   +1 more source

E‐REVEAL Lite 2.0 scoring for early prediction of disease progression in pulmonary arterial hypertension

Pulmonary Circulation, 2022
Risk stratification is an essential tool in the management of pulmonary arterial hypertension (PAH). These tools lack detailed echocardiographic assessment which plays a central role in clinical risk assessment in PAH. Thus, we aimed at assessing whether
Sandeep Sahay, Jiken Bhatt, Sarah Beshay, Ashrith Guha, Duc T. Nguyen, Edward A. Graviss, Sherif F. Nagueh   +6 more
doaj   +1 more source

PRSice: Polygenic Risk Score software [PDF]

Bioinformatics, 2014
Abstract Summary: A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide association study. The application of PRS has grown in recent years as their utility for detecting shared genetic aetiology among traits has become appreciated; PRS ...
Euesden, Jack, Lewis, Cathryn M, O'Reilly, Paul F   +2 more
openaire   +6 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Machine Learning Framework to Identify Individuals at Risk of Rapid Progression of Coronary Atherosclerosis: From the PARADIGM Registry. [PDF]

, 2020
Background Rapid coronary plaque progression (RPP) is associated with incident cardiovascular events. To date, no method exists for the identification of individuals at risk of RPP at a single point in time.
Al'Aref, Subhi J, Andreini, Daniele, Baskaran, Lohendran, Bax, Jeroen J, Berman, Daniel S, Budoff, Matthew J, Cademartiri, Filippo, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Choi, Jung Hyun, Chun, Eun Ju, Conte, Edoardo, de Araújo Gonçalves, Pedro, Gottlieb, Ilan, Gransar, Heidi, Hadamitzky, Martin, Han, Donghee, Kim, Yong-Jin, Kolli, Kranthi K, Lee, Byoung Kwon, Lee, Sang-Eun, Leipsic, Jonathon A, Lin, Fay Y, Maffei, Erica, Marques, Hugo, Min, James K, Narula, Jagat, Pontone, Gianluca, Raff, Gilbert L, Samady, Habib, Shaw, Leslee J, Shin, Sangshoon, Stone, Peter, Sung, Ji Min, van Rosendael, Alexander R, Virmani, Renu   +35 more
core  

Endothelial function assessment in atherosclerosis: Comparison of brachial artery flow‑mediated vasodilation and peripheral arterial tonometry [PDF]

, 2013
INTRODUCTION Endothelial dysfunction, characterized by the loss of nitric oxide bioavailability, is a key element in the pathogenesis of atherosclerosis and an important prognostic factor in cardiovascular diseases. Therefore, the development of reliable,
Czesnikiewicz-Guzik, Marta, Guzik, Tomasz J., Ignacak, Adam, Jasiewicz‑Honkisz, Barbara, Matusik, Paweł, Nowakowski, Daniel, Osmenda, Grzegorz, Wilk, Grzegorz   +7 more
core   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Heterogeneity of cancer-associated fibroblast subpopulations in prostate cancer: Implications for prognosis and immunotherapy

Translational Oncology
Background: Prostate cancer stands as the second most common malignancy among men, notorious for its intricate heterogeneity, especially evident in metastatic disease.
Chen Ding, Jiange Wang, Jie Wang, Jiqiang Niu, Zhikai Xiahou, Zhou Sun, Zhenzhen Zhao, Dongyang Zeng   +7 more
doaj   +1 more source

Cardiovascular risk factors in 7-13 years old children from Vojvodina (Serbia) [PDF]

Journal of Medical Biochemistry, 2016
Background: Atherosclerosis is a chronic inflammatory disease which starts early in life and depends on many factors, an important one being dyslipoproteinemia.
Dželajlija Darko D., Spasić Slavica S., Kotur-Stevuljević Jelena M., Bogavac-Stanojević Nataša B.   +3 more
doaj  

Outcomes and risk score for distal pancreatectomy with celiac axis resection (DP-CAR) : an international multicenter analysis [PDF]

, 2019
Background: Distal pancreatectomy with celiac axis resection (DP-CAR) is a treatment option for selected patients with pancreatic cancer involving the celiac axis.
Adham, Mustapha, Bassi, Claudio, Berrevoet, Frederik, Besselink, Marc G, Boggi, Ugo, Busch, Olivier R, Cesaretti, Manuela, Dalla Valle, Raffaele, Darnis, Benjamin, Del Chiaro, Marco, Diener, Markus K, Dumitrascu, Traian, Friess, Helmut, Fusai, Giuseppe K, Gerritsen, Sarah L, Gruetzmann, Robert, Hackert, Thilo H, Hirono, Seiko, Hogg, Melissa E, Ivanecz, Arpad, Javed, Ammar A, Karayiannakis, Anastasios, Kawai, Manabu, Kleeff, Jorg, Klompmaker, Sjors, Labori, Knut J, Lesurtel, Mickael, Lombardo, Carlo, Lopez-Ben, Santiago, Mabrut, Jean-Yves, Miyazawa, Motoki, Moser, A James, Niesen, Willem, Okada, Ken-ichi, Pardo, Fernando, Perinel, Julie, Peters, Niek A, Popescu, Irinel, Prasad, Raj, Roeyen, Geert, Salvia, Roberto, Sauvanet, Alain, Sturesson, Christian, Teresa Albiol, M, Van Gulik, Thomas M, Van Hilst, Jony, Weiss, Matthew J, Wolfgang, Christopher L, Yamaue, Hiroki, Zeh, Herbert J, Zureikat, Amer H   +50 more
core   +2 more sources