Results 61 to 70 of about 553,892 (263)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

The Risk of Tradition: With de Certeau toward a Postmodern Catholic Theory

open access: yesJournal of Moral Theology, 2021
This article centres on a controversial essay by Michel de Certeau, "How is Christianity Thinkable Today?" De Certeau's essay articulates a postmodern theory of tradition by identifying the core of the Christian faith as the "event" or "inaugural rupture"
Philipp W. Rosemann
doaj  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

The Theory of Risk

open access: yesJournal of the Royal Statistical Society Series B: Statistical Methodology, 1967
Summary The classical theory of risk is reviewed. It is shown to be a static theory and this is adduced to be its main disadvantage. A dynamic theory was introduced by Lundberg in 1909. This is discussed and Lundberg's achievement is reaffirmed.
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Recent Developments in Sociological Risk Theory

open access: yesForum: Qualitative Social Research, 2006
This article gives a brief overview of the main streams and recent developments of sociological research and theorising on risk. It outlines shifts in cultural theory on risk, from risk society to reflexive modernisation, from governmentality on risk to ...
Jens O. Zinn
doaj  

Drive Risk Assessment Based on Game Theory Combinatorial Weighting—Unascertained Measure Theory

open access: yesJournal of Advanced Transportation
The driving risk is assessed using the theory of unascertained measures to determine the presence of a conditional switch in the control system of a human-machine codriving vehicle. Relevant risk indicators for driving are selected, including five driver-
Lingyu Zhang   +3 more
doaj   +1 more source

Development of the theory of organizational risk management [PDF]

open access: yesSHS Web of Conferences
This study examines the evolving role of risk management in organizations, particularly in Russia’s mobilization economy. The primary aim is to explore how organizations can effectively manage emerging risks and maintain sustainability while pursuing ...
Aksana Turgaeva   +3 more
doaj   +1 more source

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