Results 81 to 90 of about 579,201 (262)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Process Theory of Supplier Cyber Risk Assessment
Australasian Journal of Information SystemsManaging cyber risk in the supply chain represents one of the most significant challenges in cyber risk management. The paper studies how organizations assess supplier cyber risk. We used a mixed-method approach.
Sergeja Slapnicar +2 more
doaj +1 more source
RISK AVERSION AND MOTOR INSURANCE DEMAND: EMPIRICAL EVIDENCE FROM NIGERIA [PDF]
Annals of the University of Craiova: Economic Sciences Series, 2019 Insurance demand is often pushed by high level aversion of risk. Risk aversion is seen as the heartbeat of the demand for insurance. Therefore, this study examined the relationships between risk aversion and insurance demand with its empirical findings ...
Sunday Stephen AJEMUNIGBOHUN +1 more
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
An Optional Semimartingales Approach to Risk Theory
RisksThis paper aims to develop optional semimartingale methods in risk theory to allow for a larger class of risk models. Optional semimartingales are left-continuous with right-limit stochastic processes defined on a probability space where the usual ...
Mahdieh Aminian Shahrokhabadi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Incorporating competing risk theory into evaluations of changes in cancer survival: making the most of cause of death and routinely linked sociodemographic data. [PDF]
BMC Public Health, 2020 Wright CM +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Risk modification on the part of managers
Ekonomski Vjesnik, 2012 The paper aims to determine how and how often Croatian managers modify the risk in business situations. The paper includes results of a survey conducted among the sample of managers employed at middle and senior management levels in Croatian companies.
Perica Vojinić
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source