Results 61 to 70 of about 612,030 (261)

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Risk of beta: Evidence from Prospect Theory [PDF]

open access: yesمطالعات تجربی حسابداری مالی, 2015
According to Prospect Theory, Investors have different behaviors in theprofit and loss situations and indeed their trading behavior is different in bulland bear markets.
Ali Saghafi   +2 more
doaj  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Does Financial Performance Shield Greenwashers? Evidence from European Firms

open access: yesScientific Annals of Economics and Business
This paper attempts to examine the impact of greenwashing on firms’ risk and the shielding effect of financial performance across different sustainability conditions.
Seyfullah Selimefendigil
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Theoretical aspects of risks categorisation

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2010
Risk is the one of basic and inevitable characteristics of every human activity. In connection with business activities, it is the factor that is not possible to entirely eliminate.
Dana Martinovičová   +3 more
doaj   +1 more source

A Risk Approach by Credibility Theory

open access: yesFuzzy Information and Engineering, 2013
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Georgescu, Irina, Kinnunen, Jani
openaire   +2 more sources

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