Results 71 to 80 of about 542,647 (304)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
An Investigation of Response Bias Associated with Electronically Delivered Risk-Tolerance Assessment
Journal of Financial Therapy, 2011 <p><em>A randomized experimental study was designed to compare risk-tolerance scores for those who completed a paper-and-pen risk-tolerance assessment instrument (i.e., the control group) to those who answered the same questions using an ...
John E. Grable, Sonya L. Britt
doaj +1 more source
Misclassifications in financial risk tolerance
, 2014 This paper analyses the empirical risk tolerance of individuals and the role of physiological measures of risk perception. By using a test that mimics the financial decision process in a laboratory setting (N = 445), we obtained an ex-post empirical ...
Uberti, Pierpaolo +4 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Cogent EducationThis study demonstrates that personality traits affect investment scam vulnerability, either directly or indirectly, through risk tolerance. This study uses the Big Five personality traits, specifically openness to experience, conscientiousness ...
Elisa Tjondro +3 more
doaj +1 more source
Risk tolerance and protective behavior.
, 2022 Agents with high risk tolerance are likely to continue to participate in the social sphere despite a shelter in place order. Agents start off with a “baseline” risk tolerance that is a decreasing function of age and update it over time as other agents in
Nicholas Willems (11986305) +3 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Entrepreneurial Interest Among Santri within HEBITREN and Its Impact on MSMEs
International Journal of Islamic Business and Economics (IJIBEC)This study investigates the factors influencing entrepreneurial interest among students (santri) in Islamic boarding schools (pesantren) affiliated with HEBITREN (Himpunan Ekonomi Bisnis Pesantren, or Pesantren Business Economics Association) in Solo ...
Asep Maulana Rohimat +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source