Results 121 to 130 of about 51,631 (281)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Consistency in Risky Choice

open access: yes
Examining the influence of contextual factors on consistency of risky ...
Jake Spicer   +2 more
core   +1 more source

Effect of Graph Scale on Risky Choice: Evidence from Preference and Process in Decision-Making.

open access: yes, 2016
We investigate the effect of graph scale on risky choices. By (de)compressing the scale, we manipulate the relative physical distance between options on a given attribute in a coordinate graphical context.
Nicolao Bonini   +11 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Limits on Predictability of Risky Choice Behavior. [PDF]

open access: yes, 2020
Research in decision-making has recently begun to empha-size predictive accuracy as the dominant principle for design-ing and evaluating choice models. This emphasis has led tothe development of increasingly more precise models of hu-mans’ risk preferences, as measured in certain experimentalparadigms built upon certainty equivalence testing.
Sifar, Anjali, Srivastava, Nisheeth
openaire   +1 more source

Household risky asset choice: an empirical study using BHPS

open access: yes, 2012
Using the BHPS data, we have carried out three empirical studies to investigate household risky asset choice in the UK. In the first study we follow appropriate econometric procedures to identify household specific factors that can be observed to ...
Kong, Dejing
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Anticipated regret and self-esteem in the Allais paradox [PDF]

open access: yes
Our experiment aims at studying the impact of self-esteem on risk-prone choices in an Allais-type decision context using hypothetical money. We use an Internet protocol in order to reach a large heterogeneous student population sample.
Emmanuel PETIT (GREThA, CNRS, UMR 5113)   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

D2/3 Agonist during Learning Potentiates Cued Risky Choice. [PDF]

open access: yesJ Neurosci, 2023
Mortazavi L   +8 more
europepmc   +1 more source

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