Results 241 to 250 of about 449,299 (288)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source
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Risky Choices?

Journalism Studies, 2017
Attempts to establish reliable predictors of journalists’ perceptions of the acceptability of various controversial newsgathering practices such as deception and intrusion have so far produced inconsistent results. This paper proposes an exploratory theoretical model, based on risk-taking theory, which identifies constructs that could be used to ...
James Hollings   +2 more
openaire   +1 more source

Incremental Evaluation of Risky Choices

Journal of the Operational Research Society, 1983
This paper compares the incremental method of valuation and its possible effects on choices analysed through utility theory with similar zero-base valuations. Analysis shows how biases can arise using incremental valuations in situations with decreasing risk aversion. This could be important in certain circumstances, e.g.
Lioukas, S. K., Moore, P. G.
openaire   +3 more sources

Risky Choice and Weber's Law

Journal of Theoretical Biology, 1998
We present a family of models of choice between behavioural alternatives with stochastic outcomes (risky choice) based on the effects of Weber's Law in memory. These models generalise and extend a model of risk sensitive foraging originally proposed by Reboreda & Kacelnik [(1991) Behav. Ecol.
A, Kacelnik, F, Brito e Abreu
openaire   +2 more sources

Risky Choice in the Limelight

SSRN Electronic Journal, 2012
This paper examines how risk behavior in the limelight differs from that in anonymity. In two separate experiments we find that subjects are more risk averse in the limelight. However, risky choices are similarly path dependent in the different treatments.
van den Assem, Martijn J.   +2 more
openaire   +3 more sources

Endowments and risky choice

Journal of Economic Behavior & Organization, 2019
Abstract We report evidence of an endowment effect for risk, extending previous results to the popular paired-choice lottery setting. Specifically, we observe a distribution of revealed preferences consistent with risk aversion that diminishes in endowed variance, although the effect is considerably weaker for compound relative to simple lotteries ...
Erin Crockett, Sean Crockett
openaire   +1 more source

The minority decision — A risky choice

Journal of Experimental Social Psychology, 2015
Abstract Objects are evaluated more extremely if they are rare. As minority positions represent low consensus (i.e., only few others agree), they are associated not only with high gains if correct, but also with high losses if wrong. This renders the minority position a risky option.
Erb, Hans-Peter   +3 more
openaire   +2 more sources

Ordering Risky Choices

2002
This chapter connects assumptions about probability distributions, decision makers’ risk attitudes, and the resulting methods used to order risky choices. The methods we discuss are consistent with the expected utility hypothesis because up to this point in time no alternative for decision making under risk has gained widespread acceptance.
Lindon J. Robison, Robert J. Myers
openaire   +1 more source

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