Results 91 to 100 of about 68,908 (269)

Safety and acceptability of clozapine and risperidone in progressive multiple sclerosis: a phase I, randomised, blinded, placebo-controlled trial

BMJ Neurology Open, 2020
Objective Because clozapine and risperidone have been shown to reduce neuroinflammation in humans and mice, the Clozapine and Risperidone in Progressive Multiple Sclerosis (CRISP) trial was conducted to determine whether clozapine and risperidone are ...
Sean Lance, Anne C La Flamme, David Abernethy, Dalice Sim, Liz Goode, Michelle Lockhart, David Bourke, Imogen Milner, Toni-Marie Garrill, Purwa Joshi, Eloise Watson, Duncan Smyth, Bronwen Connor   +12 more
doaj   +1 more source

The experience of body image in people with psychosis and psychotic‐like experiences: A co‐produced mixed‐methods systematic review and narrative synthesis

Psychology and Psychotherapy: Theory, Research and Practice, EarlyView.
Abstract Purpose Body image is a transdiagnostic construct that seems poorly understood in psychosis. Poor body image is associated with paranoia, which makes it a theoretically meaningful treatment target in psychosis. We systematically reviewed associations between body image and psychosis symptoms in both the ‘general’ population and people living ...
Jenna McAllister, Sophie M. Allan, Alie Phiri, Kara Keddie, Tracey McKee, Leonie Richardson, Felicity Waite, Rebekah Carney, Gillian MacAfee, Andrew Gumley, Stephanie Allan   +10 more
wiley   +1 more source

Chronic administration of atypical antipsychotics improves behavioral and synaptic defects of STOP null mice. [PDF]

, 2009
International audienceINTRODUCTION: Recent studies have suggested that schizophrenia is associated with alterations in the synaptic connectivity involving cytoskeletal proteins.
Annie Andrieux, Annie Schweitzer, Corinne Roucard, David Delotterie, Geoffrey Ruiz, Hôpital Le, Jacques Brocard, Karine Bress, Oise Suaud-chagny, Yann Roche   +9 more
core   +5 more sources

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

Cost-effectiveness of early responders versus early nonresponders to atypical antipsychotic therapy

ClinicoEconomics and Outcomes Research, 2011
Xiaomei Peng1, Haya Ascher-Svanum1, Douglas E Faries1, Virginia L Stauffer1, Sara Kollack-Walker1, Bruce J Kinon1, John M Kane21Eli Lilly and Company, Indianapolis, Indiana; 2Zucker Hillside Hospital, Department of Psychiatry, Glen Oaks, New York ...
Peng X, Ascher-Svanum H, Faries DE, Stauffer VL, Kollack-Walker S, Kinon BJ, Kane JM   +6 more
doaj  

Bowel incontinence associated with risperidone: A case report

Telangana Journal of Psychiatry, 2019
Introduction: Bowel incontinence due to antipsychotic drugs is rarely seen as an adverse effect. The mechanism of it is poorly understood, though alpha antagonism is believed to play an important role, along with secondary antihistaminergic action. It is
Hemendra Singh, Udayan Bhaumik, Adarsh Basaveshwara, Aditi Singh   +3 more
doaj   +1 more source

Quality of life in Romanian patients with schizophrenia based on gender, type of schizophrenia, therapeutic approach, and family history [PDF]

, 2018
The low quality of life of patients with schizophrenia has been extensively discussed and investigated. Various aspects from gender, socio-demographic profile, and/or type of neuroleptic treatment have been taken into account in describing this condition.
Alexinschi, Ovidiu Eugen, Brîncuș, Călin, Giurgiuca, Ana, Matei, Valentin Petre, Rosca, Elena Alina   +4 more
core   +3 more sources

Antipsychotic dose escalation as a trigger for Neuroleptic Malignant Syndrome (NMS): literature review and case series report [PDF]

, 2012
Background: “Neuroleptic malignant syndrome” (NMS) is a potentially fatal idiosyncratic reaction to any medication which affects the central dopaminergic system. Between 0.5% and 1% of patients exposed to antipsychotics develop the condition.
AL Pelonero, BD Berman, D Berardi, D Bereardi, D Heyland, Daniel J Smith, Daniel Martin, F-GB Pajonk, H Itoh, J Ananth, J Delay, J Gill, JF Patterson, JN Trollor, JR Strawn, Julie Langan, K Otani, KL Hall, LF Viejo, LS Friedman, M Dave, MJ Bhanushali, P Adnet, P Sachdev, P Sachdev, PE Keek, PF Buckley, PI Rosebush, PJ Alexander, Polash Shajahan, RJ Gurrera, RJ Gurrera, RW Baker, S Caroff, S Madakasira   +34 more
core   +3 more sources

Machine learning methods for predicting adverse drug events: A systematic review

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 422-444, February 2026.
Abstract Predicting adverse drug events (ADEs) in outpatient settings is crucial for improving medication safety, identifying high‐risk patients and reducing health‐care costs. While traditional methods struggle with the complexity of health‐care data, machine learning (ML) models offer improved prediction capabilities; however, their effectiveness in ...
Niaz Chalabianloo, Fatemeh Ahmadi, Mohammad Ali Omrani, Sheikh S. Abdullah, Neda Rostamzadeh, Atefeh Jafari, Lujain Izzedin, Kamran Sedig, Flory T. Muanda   +8 more
wiley   +1 more source

Enantioconvergent Access to Chiral S(VI) Stereocenters by Kinetic Resolution of Sulfonimidoyl Chlorides

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
An enantioconvergent approach for the kinetic resolution of S(VI) stereocenters that leverages the electrophilic reactivity of the chiral sulfur atom is described. The catalytic process provides access to sulfonimidoyl chlorides and sulfonimidates, which are among the least studied S(VI) functionalities.
Arko Das, Shree Krishna Dhakal, Ramon Trevino, Seth O. Fremin, Vy T. B. Nguyen, Arka Porey, Sachchida Nand, Chandan Kumar Giri, Daniel J. Wherritt, Hadi D. Arman, Oleg V. Larionov   +10 more
wiley   +2 more sources