Results 41 to 50 of about 1,222,932 (294)

Test Experience, Direct Instruction, and Their Combination Promote Accurate Beliefs about the Testing Effect

Journal of Intelligence, 2023
Practice testing is a highly robust learning strategy that promotes long-term retention, especially in comparison to more passive strategies such as restudying—a finding referred to as the testing effect.
Michelle L. Rivers
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Microbiological and Physicochemical Characterization of Abattoir Wastewater in Obio/Akpor Local Government Area of Rivers State, Nigeria

Juvenis Scientia
Introduction. The spread of pathogenic bacteria from food production processes has become a problem worldwide. Abattoir effluents are potential carriers of resistant pathogenic bacteria and could contribute to these strains’ global spread in the ...
Aleruchi, O., Okundaye, O.G., Ekongson, W., Isaac, A.H., Harold, I.   +4 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Predictors of COVID-19 vaccine hesitancy among biomedical students of Rivers State University

Academia Medicine
Despite vaccination progress and a return to normalcy, new SARS-CoV-2 variants highlight the ongoing threat and potential for future pandemics. This reemphasizes the importance of studying specific demographics, such as university students, to
Moore Ikechi Mike-Ogburia, Gift Mibilanyeofori Hart, Barynem Vito-Peter, Aisha Dio, Victory Chidinma Nwogu   +4 more
doaj   +1 more source

Singing streams: Describing freshwater soundscapes with the help of acoustic indices

Ecology and Evolution, 2020
Understanding soundscapes, that is, the totality of sounds within a location, helps to assess nature in a more holistic way, providing a novel approach to investigating ecosystems.
Emilia Decker, Brett Parker, Simon Linke, Samantha Capon, Fran Sheldon   +4 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The effect of deuterated PLK1 inhibitor on its safety and efficacy in vivo

Frontiers in Oncology
BackgroundThe FDA’s approval of deutetrabenazine, the first deuterium-labeled drug, demonstrated an improved safety profile compared to its non-deuterated counterpart, tetrabenazine. While Polo-like kinase 1 (PLK1) inhibitors have shown promise in cancer
Tingyan Zhang, Tingyan Zhang, Xiaobing Deng, Haoping Jin, Zhengshu Peng, Zhengshu Peng, Yi-Ching Hsueh, Chunming Zhang, Gang Niu, Gang Niu, Jianfei Yang, Jianfei Yang   +11 more
doaj   +1 more source

Sharing a River [PDF]

Journal of Economic Theory, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ambec, Stefan, Sprumont, Yves
openaire   +6 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source