Results 1 to 10 of about 50,486 (146)

IL-15 and N-803 for HIV Cure Approaches

Viruses, 2023
In spite of the advances in antiretroviral therapy to treat HIV infection, the presence of a latent reservoir of HIV-infected cells represents the largest barrier towards finding a cure. Among the different strategies being pursued to eliminate or reduce
J. Howard, A. Bosque
semanticscholar   +1 more source

Rendu-Osler-Weber syndrome: dermatological approach [PDF]

Anais Brasileiros de Dermatologia, 2015
The Rendu-Osler-Weber syndrome is a rare systemic fibrovascular dysplasia, recognized by mucocutaneous telangiectasias, arteriovenous malformations, epistaxis and family history.
Aline Blanco Barbosa, Günter Hans Filho, Carolina Faria dos Santos Vicari, Marcelo Zanolli Medeiros, Daíne Vargas Couto, Luiz Carlos Takita   +5 more
doaj   +1 more source

ALT-803 in the treatment of non-muscle-invasive bladder cancer: Preclinical and clinical evidence and translational potential

Frontiers in Immunology, 2022
Bladder cancer (BCa) is one of the most common malignant tumors that cause death. Approximately 75%–85% of BCa develop into non-muscle-invasive bladder cancer (NMIBC).
Wujun Chen, Ning Liu, Yang Yuan, Mengou Zhu, Xiaokun Hu, Wenchao Hu, Shuai Wang, Chao Wang, Binghuan Huang, Dongming Xing   +9 more
semanticscholar   +1 more source

Control of Simian Immunodeficiency Virus Infection in Prophylactically Vaccinated, Antiretroviral Treatment-Naive Macaques Is Required for the Most Efficacious CD8 T Cell Response during Treatment with the Interleukin-15 Superagonist N-803

Journal of Virology, 2022
N-803 is a drug that boosts the immune cells involved in combating HIV/SIV infection. Here, we found that in SIV+ rhesus macaques that were not on antiretroviral therapy, N-803 increased the proliferation and potential capacity for killing of the SIV ...
Amy L. Ellis-Connell, Alexis J. Balgeman, Olivia E. Harwood, Ryan V. Moriarty, J. Safrit, A. Weiler, T. Friedrich, Shelby L. O’Connor   +7 more
semanticscholar   +1 more source

Design, Synthesis and Biological Evaluation of [1,2,4]Triazolo[1,5-a]pyrimidine Indole Derivatives against Gastric Cancer Cells MGC-803 via the Suppression of ERK Signaling Pathway

Molecules, 2022
[1,2,4]Triazolo[1,5-a]pyrimidine and indole skeletons are widely used to design anticancer agents. Therefore, in this work, a series of [1,2,4]triazolo[1,5-a]pyrimidine indole derivatives were designed and synthesized by the molecular hybridization ...
Guangyao Yu, Ying Hu, Wei-Xin Zhang, Xinyong Tian, Sai-Yang Zhang, Yan Zhang, Shuo Yuan, Jian Song   +7 more
semanticscholar   +1 more source

The Immune Function of Keratinocytes in Anti-Pathogen Infection in the Skin

International Journal of Dermatology and Venerology, 2020
. Keratinocytes, located in the outer part of human skin, are the main epidermal cell type and play an essential role in skins defense against infection.
Jia-Ning Wang, Min Li
doaj   +1 more source

Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Previous proteomic analyses of host factors targeted for down-regulation by human cytomegalovirus (HCMV) have focused on early or intermediate stages of infection. Using multiplexed proteomics, we have systematically identified viral factors
K. Nightingale, Martin Potts, Leah M. Hunter, C. Fielding, Cassie M Zerbe, Alice Fletcher-Etherington, L. Nobre, E. Wang, B. L. Strang, J. Houghton, R. Antrobus, N. Suárez, J. Nichols, A. Davison, R. Stanton, M. Weekes   +15 more
semanticscholar   +1 more source

Erosive Adenomatosis of the Nipple Masquerading as Paget's Disease: A Case Report

International Journal of Dermatology and Venerology, 2020
. Introduction:. Erosive adenomatosis of the nipple is a rare benign lesion involving nipple which can be easily misdiagnosed as more ominous entities such as Pagets disease.
Qin Guo, Jin Ji, Cheng Tan, Qi Zhang, Su-Ying Feng   +4 more
doaj   +1 more source

Genome-Based Characterization of Plant-Associated Rhodococcus qingshengii RL1 Reveals Stress Tolerance and Plant–Microbe Interaction Traits

Frontiers in Microbiology, 2021
Stress tolerant, plant-associated bacteria can play an important role in maintaining a functional plant microbiome and protecting plants against various (a)biotic stresses.
T. Kuhl, S. Chowdhury, J. Uhl, M. Rothballer   +3 more
semanticscholar   +1 more source

Control of SIV infection in prophylactically vaccinated, ART-naïve macaques is required for the most efficacious CD8 T cell response during treatment with the IL-15 superagonist N-803

bioRxiv, 2022
The IL-15 superagonist N-803 has been shown to enhance the function of CD8 T cells and NK cells. We previously found that in a subset of vaccinated, ART-naïve, SIV+ rhesus macaques, N-803 treatment led to a rapid but transient decline in plasma viremia ...
Amy L. Ellis-Connell, Alexis J. Balgeman, Olivia E. Harwood, Ryan V. Moriarty, J. Safrit, A. Weiler, T. Friedrich, Shelby L. O’Connor   +7 more
semanticscholar   +1 more source