Results 11 to 20 of about 58,868 (161)

Comprehensive Management of Acute Ischemic Stroke in Psoriatic Patient

Case Reports in Dermatological Medicine, 2023
Background. Stroke is one of the top causes of death and disability in several nations. Patients with psoriasis are susceptible to multiple comorbidities, including stroke.
Al Rasyid, Taufik Mesiano, Mohammad Kurniawan, Rakhmad Hidayat, Reyhan Eddy Yunus, Endi Novianto, Ocktafiani Ocktafiani, Elvan Wiyarta, Salim Harris   +8 more
doaj   +1 more source

IL-15 and N-803 for HIV Cure Approaches

Viruses, 2023
In spite of the advances in antiretroviral therapy to treat HIV infection, the presence of a latent reservoir of HIV-infected cells represents the largest barrier towards finding a cure. Among the different strategies being pursued to eliminate or reduce
J. Howard, A. Bosque
semanticscholar   +1 more source

A Survey of Brazilian Patients with Oral Lichen Planus Showing No Evidence of Malignancy

Dermatology Research and Practice, 2022
Objectives. There is conflicting evidence as to whether oral lichen planus (OLP) can undergo malignant transformation into oral squamous cell carcinoma (OSCC). This study aimed to address this issue by analyzing a sample of Brazilian patients with either
Dante Migliari, Norberto Sugaya, Silvio Hirota   +2 more
doaj   +1 more source

Clouston Syndrome: Report of a Jordanian Family with GJB6 Gene Mutation

Case Reports in Dermatological Medicine, 2023
Ectodermal dysplasias (ED) encompass a collection of conditions wherein the development of two or more structures derived from the ectoderm exhibits abnormal patterns.
Rand Murshidi, Heba Al-lala
doaj   +1 more source

ALT-803 in the treatment of non-muscle-invasive bladder cancer: Preclinical and clinical evidence and translational potential

Frontiers in Immunology, 2022
Bladder cancer (BCa) is one of the most common malignant tumors that cause death. Approximately 75%–85% of BCa develop into non-muscle-invasive bladder cancer (NMIBC).
Wujun Chen, Ning Liu, Yang Yuan, Mengou Zhu, Xiaokun Hu, Wenchao Hu, Shuai Wang, Chao Wang, Binghuan Huang, Dongming Xing   +9 more
semanticscholar   +1 more source

Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Previous proteomic analyses of host factors targeted for down-regulation by human cytomegalovirus (HCMV) have focused on early or intermediate stages of infection. Using multiplexed proteomics, we have systematically identified viral factors
K. Nightingale, Martin Potts, Leah M. Hunter, C. Fielding, Cassie M Zerbe, Alice Fletcher-Etherington, L. Nobre, E. Wang, B. L. Strang, J. Houghton, R. Antrobus, N. Suárez, J. Nichols, A. Davison, R. Stanton, M. Weekes   +15 more
semanticscholar   +1 more source

Design, Synthesis and Biological Evaluation of [1,2,4]Triazolo[1,5-a]pyrimidine Indole Derivatives against Gastric Cancer Cells MGC-803 via the Suppression of ERK Signaling Pathway

Molecules, 2022
[1,2,4]Triazolo[1,5-a]pyrimidine and indole skeletons are widely used to design anticancer agents. Therefore, in this work, a series of [1,2,4]triazolo[1,5-a]pyrimidine indole derivatives were designed and synthesized by the molecular hybridization ...
Guangyao Yu, Ying Hu, Wei-Xin Zhang, Xinyong Tian, Sai-Yang Zhang, Yan Zhang, Shuo Yuan, Jian Song   +7 more
semanticscholar   +1 more source

Safety, Tolerability, and Long-Term Clinical Outcomes of an IL-15 analogue (N-803) Admixed with Bacillus Calmette-Guérin (BCG) for the Treatment of Bladder Cancer

Oncoimmunology, 2021
Intravesical BCG is active against non-muscle invasive bladder cancer (NMIBC), but bladder cancer will recur and even progress in a significant number of patients. To improve the response rate, N-803, an IL-15 superagonist was administered in combination
C. Rosser, Sergei N Tikhonenkov, J. Nix, O. Chan, Irina Ianculescu, S. Reddy, P. Soon-Shiong   +6 more
semanticscholar   +1 more source

Phase I Trial of N-803, an IL15 Receptor Agonist, with Rituximab in Patients with Indolent Non-Hodgkin Lymphoma

Clinical Cancer Research, 2021
Purpose: N-803 is an IL15 receptor superagonist complex, designed to optimize in vivo persistence and trans-presentation, thereby activating and expanding natural killer (NK) cells and CD8+ T cells. Monoclonal antibodies (mAbs) direct Fc receptor–bearing
J. Foltz, B. Hess, V. Bachanova, N. Bartlett, M. Berrien-Elliott, Ethan McClain, M. Becker-Hapak, M. Foster, Timothy Schappe, B. Kahl, N. Mehta-Shah, A. Cashen, Nancy D. Marin, Kristen McDaniels, Chaz Moreno, Matthew Mosior, F. Gao, O. Griffith, M. Griffith, Julia A Wagner, N. Epperla, A. Rock, John H. Lee, A. Petti, P. Soon-Shiong, T. Fehniger   +25 more
semanticscholar   +1 more source

Combinatorial immunotherapy of N-803 (IL-15 superagonist) and dinutuximab with ex vivo expanded natural killer cells significantly enhances in vitro cytotoxicity against GD2+ pediatric solid tumors and in vivo survival of xenografted immunodeficient NSG mice

Journal for ImmunoTherapy of Cancer, 2021
Background Children with recurrent and/or metastatic osteosarcoma (OS), neuroblastoma (NB) and glioblastoma multiforme (GBM) have a dismal event-free survival (
Y. Chu, Gaurav Nayyar, Susiyan Jiang, J. Rosenblum, P. Soon-Shiong, J. Safrit, Dean Anthony Lee, M. Cairo   +7 more
semanticscholar   +1 more source