Results 11 to 20 of about 43,660 (119)

A New TGF-β Mimetic, XEP™-716 Miniprotein™, Exhibiting Regenerative Properties Objectivized by Instrumental Evaluation

Dermatology and Therapy
Introduction Skin aging, which results from intrinsic and extrinsic factors, is characterized by a rough, uneven and wrinkled appearance of the skin at the macroscopic level.
Hanane Chajra, Thibaut Saguet, Corinne Granger, Lionel Breton, Pedro Contreiras Pinto, Mickael Machicoane, Jean Marc Le Doussal   +6 more
doaj   +1 more source

Development and Validation of a Patient-Reported Outcome Measure of the Impact of Chronic Hand Eczema on Health-Related Quality of Life: the Hand Eczema Impact Scale (HEIS)

Dermatology and Therapy
Introduction Chronic Hand Eczema (CHE) is an inflammatory skin disease that causes significant impact on health-related quality of life (HRQoL). The Hand Eczema Impact Scale (HEIS) is a new patient-reported outcome (PRO) measure designed to assess the ...
Elke Weisshaar, Yasemin Topal Yüksel, Tove Agner, Lotte Seiding Larsen, Laura Grant, Rob Arbuckle, Amy M. Jones, Piper Fromy, Cherry Lou Balita-Crisostomo, Nanna Nyholm Mathiasen, Henrik Thoning, Christian Apfelbacher   +11 more
doaj   +1 more source

Drug Repurposing Using Molecular Network Analysis Identifies Jak as Targetable Driver in Necrobiosis Lipoidica

JID Innovations
Drug repurposing is an attractive strategy for therapy development, particularly in rare diseases where traditional drug development approaches may be challenging owing to high cost and small numbers of patients.
Alysia N. Hughes, Xing Li, Julia S. Lehman, Steven A. Nelson, David J. DiCaudo, Rekha Mudappathi, Angelina Hwang, Jacob Kechter, Mark R. Pittelkow, Aaron R. Mangold, Aleksandar Sekulic   +10 more
doaj   +1 more source

Long-Term Efficacy and Tolerability of an Emollient Containing Glycerol and Paraffin for Moderate-to-Severe Uremic Xerosis: A Randomized Phase 3 Study

Dermatology and Therapy
Introduction There is an unmet need for effective topical therapies for patients with uremic xerosis and chronic kidney disease-associated pruritus (CKD-aP). The long-term efficacy and tolerability of an emollient containing glycerol 15% and paraffin 10%
Jacek C. Szepietowski, Lajos Kemeny, Thomas Mettang, Petr Arenberger   +3 more
doaj   +1 more source

Transcriptomic Analyses Predict Enhanced Metabolic Activity and Therapeutic Potential of mTOR Inhibitors in Acne-Prone Skin

JID Innovations
Current acne therapies center on preventing new lesions in patients with acne. These therapies were historically found to be beneficial yet were chosen without knowledge of the specific changes in the skin that favor lesion development. A major challenge
Mackenzie L. Sennett, George W. Agak, Diane M. Thiboutot, Amanda M. Nelson   +3 more
doaj   +1 more source

A genome-wide association study of total child psychiatric problems scores. [PDF]

PLoS One, 2022
Neumann A, Nolte IM, Pappa I, Ahluwalia TS, Pettersson E, Rodriguez A, Whitehouse A, van Beijsterveldt CEM, Benyamin B, Hammerschlag AR, Helmer Q, Karhunen V, Krapohl E, Lu Y, van der Most PJ, Palviainen T, St Pourcain B, Seppälä I, Suarez A, Vilor-Tejedor N, Tiesler CMT, Wang C, Wills A, Zhou A, Alemany S, Bisgaard H, Bønnelykke K, Davies GE, Hakulinen C, Henders AK, Hyppönen E, Stokholm J, Bartels M, Hottenga JJ, Heinrich J, Hewitt J, Keltikangas-Järvinen L, Korhonen T, Kaprio J, Lahti J, Lahti-Pulkkinen M, Lehtimäki T, Middeldorp CM, Najman JM, Pennell C, Power C, Oldehinkel AJ, Plomin R, Räikkönen K, Raitakari OT, Rimfeld K, Sass L, Snieder H, Standl M, Sunyer J, Williams GM, Bakermans-Kranenburg MJ, Boomsma DI, van IJzendoorn MH, Hartman CA, Tiemeier H.   +60 more
europepmc   +1 more source

Automatic Acne Severity Grading with a Small and Imbalanced Data Set of Low-Resolution Images

Dermatology and Therapy
Introduction Developing automatic acne vulgaris grading systems based on machine learning is an expensive endeavor in terms of data acquisition. A machine learning practitioner will need to gather high-resolution pictures from a considerable number of ...
Rémi Bernhard, Arnaud Bletterer, Maëlle Le Caro, Estrella García Álvarez, Belchin Kostov, Diego Herrera Egea   +5 more
doaj   +1 more source

Regulated Medical Waste Reduction in the Dermatology Clinic

Dermatology and Therapy
Introduction The disposal of regulated medical waste (RMW) in the healthcare setting can be both costly and environmentally harmful. Prior studies have found large amounts of waste disposed of in RMW containers are inappropriately placed.
Divya K. Sharma, Lilia C. Murase, Misha Rosenbach, John S. Barbieri, Jenny E. Murase   +4 more
doaj   +1 more source

Keratoderma-Like T-Cell Dyscrasia: A Case Report

Case Reports in Dermatology
Introduction: Cutaneous T-cell dyscrasia (CTCD) encompasses a heterogeneous group of T-cell infiltrates, often clonal and epitheliotropic. While the etiology remains unclear, certain medications, including statins, have been linked to cutaneous T-cell ...
Asem Shadid, Sukaina Al Haddad, Rua’a Alharithy, Tariq J. Al-Zaid   +3 more
doaj   +1 more source

Gastrointestinal comorbidities in patients with acne vulgaris: A population-based retrospective studyCapsule Summary

JAAD International
Background: The gut-skin-brain axis has been long postulated in acne vulgaris. Few studies focused on bowel habits in patients with acne vulgaris have yielded controversial results.
Yu-Wen Chen, MD, Chun-Ying Wu, MD, PhD, Yi-Ju Chen, MD, PhD   +2 more
doaj   +1 more source