Results 21 to 30 of about 53,462 (149)

Therapeutic Potential of IL-15 and N-803 in HIV/SIV Infection

Viruses, 2021
IL-15, a proinflammatory cytokine critical for the generation, maintenance, and homeostasis of T cell responses, is produced naturally in response to HIV/SIV infection, but has also demonstrated therapeutic potential. IL-15 can boost CD4+ and CD8+ T cell
Olivia E. Harwood, Shelby L. O’Connor
semanticscholar   +1 more source

The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques

PLoS Pathogens, 2020
Despite the success of antiretroviral therapy (ART) to halt viral replication and slow disease progression, this treatment is not curative and there remains an urgent need to develop approaches to clear the latent HIV reservoir.
G. Webb, Jhomary S Molden, K. Busman-Sahay, S. Abdulhaqq, Helen L. Wu, W. Weber, K. Bateman, J. Reed, M. Northrup, Nicholas Maier, Shiho Tanaka, Lina Gao, B. Davey, Benjamin L Carpenter, M. Axthelm, J. Stanton, J. Smedley, J. Greene, J. Safrit, J. Estes, P. Skinner, J. Sacha   +21 more
semanticscholar   +1 more source

Combination of CD8β Depletion and Interleukin-15 Superagonist N-803 Induces Virus Reactivation in Simian-Human Immunodeficiency Virus-Infected, Long-Term ART-Treated Rhesus Macaques

Journal of Virology, 2020
The “shock and kill” HIV cure strategy attempts to reverse and eliminate the latent viral infection that prevents eradication of the virus. Latency-reversing agents tested in clinical trials to date have failed to affect the HIV viral reservoir.
J. McBRIEN, A. I. Wong, E. White, D. Carnathan, John-hwa Lee, J. Safrit, T. Vanderford, M. Paiardini, A. Chahroudi, G. Silvestri   +9 more
semanticscholar   +1 more source

A case of syringocystadenoma papilliferum on lower leg: A rare location

Indian Journal of Dermatology, 2013
An 18 years old male presented with a slowly increasing multiple papulonodular lesions on his left leg since birth. No definite diagnosis was made on clinical ground.
Vinod K Khurana, Raj K Mehta, Deepak Chaudhary, Leela Pant   +3 more
doaj   +1 more source

IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34+ progenitor-derived NK cells

Cancer Immunology and Immunotherapy, 2020
Allogeneic natural killer (NK) cell transfer is a potential immunotherapy to eliminate and control cancer. A promising source are CD34 + hematopoietic progenitor cells (HPCs), since large numbers of cytotoxic NK cells can be generated. Effective boosting
J. V. D. Meer, R. Maas, K. Guldevall, K. Klarenaar, Paul De Jonge, J. H. Evert, A. B. V. D. Waart, J. Cany, J. Safrit, J. H. Lee, E. Wagena, Peter Friedl, B. Önfelt, L. Massuger, N. Schaap, J. Jansen, W. Hobo, H. Dolstra   +17 more
semanticscholar   +1 more source

First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation.

Blood, 2018
New therapies for patients with hematologic malignancies who relapse after allogeneic hematopoietic cell transplantation (allo-HCT) are needed. Interleukin 15 (IL-15) is a cytokine that stimulates CD8+ T-cell and natural killer (NK) cell antitumor ...
R. Romee, S. Cooley, M. Berrien-Elliott, P. Westervelt, M. Verneris, J. Wagner, D. Weisdorf, B. Blazar, C. Ustun, T. Defor, Sithara Vivek, L. Peck, J. Dipersio, A. Cashen, R. Kyllo, A. Musiek, A. Schaffer, M. Anadkat, I. Rosman, Daniel Miller, J. Egan, Emily K. Jeng, A. Rock, H. Wong, T. Fehniger, Jeffrey S. Miller   +25 more
semanticscholar   +1 more source

Rejuvenescimento das mãos com preenchedores cutâneos à base de ácido hialurônico: eficácia, segurança e satisfação dos pacientes durante seis meses

Surgical & Cosmetic Dermatology, 2017
Introdução: Os preenchedores à base de ácido hialurônico (AH) são considerados uma das opções de tratamento para rejuvenescimento das mãos.
Doris Hexsel, Taciana Dal'Forno Dini, Juliana Schilling de Souza, Carolina Siega   +3 more
doaj   +1 more source

Queimaduras e suas cicatrizes

Surgical & Cosmetic Dermatology, 2017
As queimaduras ainda são responsáveis por grande parte dos ferimentos e óbitos decorrentes de causas externas no Brasil, bem como por grande número de afastamento do trabalho e sequelas funcionais e estéticas, principalmente na ...
Leandra d’Orsi Metsavaht
doaj   +1 more source

DpdtC-Induced EMT Inhibition in MGC-803 Cells Was Partly through Ferritinophagy-Mediated ROS/p53 Pathway

Oxidative Medicine and Cellular Longevity, 2020
Epithelial-mesenchymal transition (EMT) is a cellular process in which epithelial cells are partially transformed into stromal cells, which endows the polarized epithelium cells more invasive feature and contributes cancer metastasis and drug resistance.
Jiankang Feng, Cuiping Li, Ruifang Xu, Yongli Li, Q. Hou, Rui Feng, Senye Wang, Lei Zhang, Changzheng Li   +8 more
semanticscholar   +1 more source

Lidocaine alleviates cisplatin resistance and inhibits migration of MGC-803/DDP cells through decreasing miR-10b

Cell Cycle, 2020
Although chemotherapy is one of the effective means of treating gastric cancer, the resistance of chemotherapeutic drugs has followed. And the mechanisms of resistance are not completely clear.
Xiaomin Zhang, G. Gu, Xuan-fei Li, Chaopei Zhang   +3 more
semanticscholar   +1 more source