Results 51 to 60 of about 58,868 (161)

Antitumor activity of nanoemulsion based on essential oil of Pinus koraiensis pinecones in MGC-803 tumor-bearing nude mice

, 2020
Essential oil is the natural extract rich in terpenoids, showing various physiological activities. Our previous studies have proved that essential oil of Pinus koraiensis pinecones (PEO) can inhibit the proliferation of MGC-803 cells and promote cell ...
Yandong Zhang, Chao Xin, Cuilin Cheng, Zhenyu Wang   +3 more
semanticscholar   +1 more source

ZYZ-803 Mitigates Endoplasmic Reticulum Stress-Related Necroptosis after Acute Myocardial Infarction through Downregulating the RIP3-CaMKII Signaling Pathway

Oxidative Medicine and Cellular Longevity, 2019
Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality worldwide, and both cardiac necroptosis and endoplasmic reticulum stress (ERS) have been involved in the pathophysiology of AMI.
Lingling Chang, Zhijun Wang, F. Ma, B. Tran, Rui Zhong, Ying Xiong, Tao Dai, Jian Wu, Xiaoming Xin, W. Guo, Ying Xie, Yicheng Mao, Yi-Zhun Zhu   +12 more
semanticscholar   +1 more source

Spectrum of interstitial lung diseases at a tertiary center in a developing country: A study of 803 subjects

PLoS ONE, 2018
Background The spectrum of interstitial lung diseases (ILDs) have mainly been reported from the developed countries; data from developing countries is sparse and conflicting.
S. Dhooria, R. Agarwal, I. Sehgal, K. Prasad, M. Garg, A. Bal, A. Aggarwal, D. Behera   +7 more
semanticscholar   +1 more source

TFAP2E methylation promotes 5-fluorouracil resistance via exosomal miR-106a-5p and miR-421 in gastric cancer MGC-803 cells

Molecular Medicine Reports, 2019
Hypermethylation of transcription factor activating enhancer-binding protein 2e (TFAP2E) has been reported to be associated with chemoresistance to 5-fluorouracil (5-FU) in gastric cancer (GC). In the present study, the molecular mechanism governing this
Jingyue Sun, W. Xiao, Zha Juanmin, Li Wei, Dao-ming Li, Xu Hong   +5 more
semanticscholar   +1 more source

The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles.

Blood Advances, 2018
Sequestering of latent HIV in follicular helper T cells within B-cell follicles that largely exclude cytotoxic T cells is a major barrier to cellular immune-based approaches to eradicate HIV. Here, we show that the clinical-grade human interleukin-15 (IL-
G. Webb, Shengbin Li, Gwantwa Mwakalundwa, J. Folkvord, J. Greene, J. Reed, Jeffery J Stanton, Alfred W Legasse, T. Hobbs, L. D. Martin, Byung S. Park, J. Whitney, J. Whitney, Emily K. Jeng, H. Wong, D. Nixon, R. B. Jones, E. Connick, P. Skinner, J. Sacha   +19 more
semanticscholar   +1 more source

Effectiveness of two different dose administration regimens of an IL-15 superagonist complex (ALT-803) in an orthotopic bladder cancer mouse model

Journal of Translational Medicine, 2019
BackgroundWe set out to determine if the administration of subcutaneous (SQ) ALT-803 was non-inferior to standard intravesical BCG treatment in a carcinogen induced mouse (C57BL/6J) bladder cancer model.MethodsUsing this well-established carcinogen ...
H. Furuya, O. Chan, I. Pagano, Chengjun Zhu, Nari Kim, R. Peres, Kanani Hokutan, Sarah Alter, P. Rhode, C. Rosser   +9 more
semanticscholar   +1 more source

An IL-15 Superagonist, ALT-803, Enhances Antibody-Dependent Cell-Mediated Cytotoxicity Elicited by the Monoclonal Antibody NEO-201 Against Human Carcinoma Cells

Cancer Biotherapy and Radiopharmaceuticals, 2019
Background: A major mechanism of action for therapeutic antibodies is antibody-dependent cell-mediated cytotoxicity (ADCC). ALT-803 is an interleukin-15 superagonist complex that enhances ADCC against human carcinoma cells in vitro and exerts an ...
M. Fantini, J. David, H. Wong, C. Annunziata, P. Arlen, K. Tsang   +5 more
semanticscholar   +1 more source

Efficacy of a topical polyphenol-based formulation in palmoplantar psoriasis: an observational study

Dermatology Reports
This single-arm observational study evaluated the efficacy and safety of a novel topical formulation containing a complex mixture of polyphenols (CMP) – a proprietary blend rich in oleocanthal and oleuropein aglycone (each >60%), along with ...
Simone Amato, Annunziata Dattola, Luigi Bennardo, Martina Tolone, Steven Paul Nisticò   +4 more
doaj   +1 more source

Post-COVID-19 resurgence of scabies in Campania, Italy: the hidden burden and challenges in surveillance

Dermatology Reports
Scabies, a contagious parasitic skin disease caused by Sarcoptes scabiei, has shown a marked resurgence in several European regions following the COVID-19 pandemic.
Caterina Mariarosaria Giorgio, Gaetano Licata, Maria Maddalena Nicoletti, Eugenia Veronica Di Brizzi, Vittorio Tancredi, Giuseppe Argenziano, Valentina Cozza, Adone Baroni   +7 more
doaj   +1 more source

Prevalence of Mycoplasma Penetrans in Urethral and Rectal Specimens from Men Attending an STI Clinic

Acta Dermato-Venereologica
Mycoplasma penetrans has gained attention in relation to non-gonococcal urethritis (NGU), a syndrome where a significant proportion of patients have no identified aetiological agent.
Mie Gesine Laake, Axel Skafte-Holm, Thomas Roland Pedersen, Jørgen Skov Jensen, Kirsten Salado-Rasmussen   +4 more
doaj   +1 more source