Results 91 to 100 of about 18,612 (273)

Trajectories of child emotional and behavioural difficulties before and during the COVID‐19 pandemic in a longitudinal UK cohort

JCPP Advances, EarlyView.
Abstract Background There are substantial age‐related changes in emotional and behavioural problems over childhood. In order to establish the impact of the Covid‐19 pandemic on child emotional and behavioural problems, longitudinal designs which take into account age‐related trends are needed.
Nicky Wright, Daphne Kounali, Elise Paul, Alex S. F. Kwong, Daniel Major‐Smith, Ilaria Costantini, Deborah A. Lawlor, Kapil Sayal, Helen Bould, Nicholas J. Timpson, Kate Northstone, Melanie Lewcock, Kate Tilling, Rebecca M. Pearson   +13 more
wiley   +1 more source

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

Pharmacological characterization of RMP-7, a novel bradykinin agonist in smooth muscle [PDF]

, 1999
RMP-7 is a bradykinin (BK) agonist designed to be resistant to kininases such as angiotensin-converting enzyme (ACE). Pharmacological assays were performed with RMP-7 in isolated guinea-pig ileum and rat mesenteric artery.
Paiva, T. B., Borges, ACR, Therezinha B Paiva, Shimuta, S. I., Ana M.R.B Barbosa, Antonio C.R Borges, Barbosa, AMRB, Suma I Shimuta   +7 more
core   +1 more source

Reverse‐Engineered Lipid Nanoparticles Harness Protein Corona Formation for Cytokine Sequestration and Combination Immunomodulatory Therapy

Small, EarlyView.
Bioinspired triglyceride‐ceramide lipid nanoparticles were reverse‐engineered from cytokine‐sequestering plant‐derived nanoparticles to capture pathological inflammatory mediators through protein corona formation. Dexamethasone‐loaded TCNPs combine extracellular cytokine sequestration with intracellular immunomodulation, reducing IL‐6, TNF‐α, and NF‐κΒ
Junsik J. Sung, Gargi Yogesh Digholkar, Ryan M. Pearson   +2 more
wiley   +1 more source

Binding of antibodies to wt and RMP-1 MPV F. [PDF]

, 2016
Binding of antibodies to wt and RMP-1 MPV F.
Xiaolin Wen (2806171), Robert A. Lamb (278997), James E. Crowe Jr. (113691), George P. Leser (312089), Jarrod J. Mousa (2806174), Jennifer Pickens (2806168), Theodore S. Jardetzky (252519)   +6 more
core   +1 more source

Risk Management Plan: Expert Review of Applications for Marketing Authorisation in the EAEU Depending on the Type of Medicinal Product (Review)

Безопасность и риск фармакотерапии
INTRODUCTION. A risk management plan (RMP) is an important document for assessing and managing risks when using a medicinal product. An RMP is provided as part of the marketing authorisation application for a medicinal product.
T. M. Bukatina, E. V. Shubnikova
doaj   +1 more source

Oxidative Damage, Energy Imbalance, and Behavioral Disruptions in Girardia tigrina Exposed to Treated Sewage Effluents

Environmental Toxicology, EarlyView.
ABSTRACT This study assessed the ecotoxicological effects of treated sewage on the freshwater planarian Girardia tigrina, integrating biochemical, energetic, and behavioral biomarkers. Planarians were exposed for 48 h to different concentrations of treated sewage (12.5%, 25%, 50%, and 100%) and compared to controls using commercial water and water from
Renata M. P. Freitas, Pedro H. Carvalho, Daniela de Melo e Silva, Carlos Gravato   +3 more
wiley   +1 more source

Integration of Micro‐CT and XRF Mapping for Multimodal 3D Analysis of Polychrome Wooden Artifacts

X-Ray Spectrometry, EarlyView.
ABSTRACT Over the past 5 years, computer applications have become crucial to archeological research. Since the 1990s, the focus has transitioned from data management tools to the development of virtual models. Recently, digital documentation of cultural heritage has gained considerable focus, with 3D modeling of objects.
Josiane E. Cavalcante, Olga Araujo, Alessandra Machado, Roberta M. P. S. Borges, Isis V. N. S. Franzi, Anderson G. de Paula, Roberta Leitão, Marcelino dos Anjos, Renato Freitas, Ricardo T. Lopes, Davi F. Oliveira   +10 more
wiley   +1 more source

When seizure counts are not seizures: Measurement error and its implications for epilepsy management and driving policy

Epilepsia, EarlyView.
Mark J. Cook, Mark P. Richardson, Andreas Schulze‐Bonhage   +2 more
wiley   +1 more source

Convergent Interval Confirmation for Three‐Step Discrete Specific Zeroing Neural Dynamics Illustrated With Repetitive Motion Planning of Redundant Manipulators

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Repetitive motion planning (RMP) for redundant manipulators with high convergent precision becomes an intense research topic due to its more degrees of freedom. In this paper, a specific zeroing neural dynamics (SZND) model for the RMP is first set up via zeroing neurodynamics.
Ying Kong, Shaoyuan Sun, Yunliang Jiang, Lin Wei   +3 more
wiley   +1 more source