Results 111 to 120 of about 58,524 (271)

Computational modelling of the pro‐ and antiarrhythmic effects of atrial high rate‐dependent trafficking of small‐conductance calcium‐activated potassium channels

The Journal of Physiology, EarlyView.
Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Stefan Meier, Dobromir Dobrev, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Research Mentorship Program (RMP) to Enhance the Research Productivity in a Psychiatric Hospital: First Report [PDF]

Electronic Physician, 2011
Background: Despite rapid movement in student research in recent years, there is still little evidence that shows the impact of students' activities on research productivity.
Zhila Afshar, Younes Ebrahimzadeh, Seyed Hamzeh Seddigh, Javad Golmirzaei, Hamidreza Mahboobi, Mohammad Esmaeil Shahrzad, Tahereh Khorgoei   +6 more
doaj  

Mechanistic insights into sex differences in atrial electrophysiology and arrhythmia vulnerability through sex‐specific computational models

The Journal of Physiology, EarlyView.
Abstract figure legend Sex‐specific models of the human atrial myocyte in normal sinus rhythm (nSR) and chronic atrial fibrillation (cAF) revealed increased alternans susceptibility in cAF males and DADs in females, driven primarily by ICaL and ryanodine receptor remodelling.
Nathaniel T. Herrera, Haibo Ni, Charlotte E. R. Smith, Yixuan Wu, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +6 more
wiley   +1 more source

Comparing immunogenicity and safety following transition from reference rituximab to biosimilar rituximab (DRL_RI) in patients with rheumatoid arthritis: a randomized, double-blind, phase 3 study

Arthritis Research & Therapy
Objectives To assess immunogenicity and safety in patients with active rheumatoid arthritis (RA) transitioning from rituximab [US-licensed rituximab: Reference Product (RP); EU-approved rituximab: Reference Medicinal Product (RMP)] to DRL_RI (proposed ...
Narendra Maharaj, Dharma Rao Uppada, Naveen Reddy, Pramod Reddy, Anastas Batalov, Delina lvanova, Nedyalka Staykova, Asta Baranauskaite, Laila Amirali Hassan   +8 more
doaj   +1 more source

Relationship between Market Structure and Bank Performance: Empirical Evidence for Central and Eastern Europe [PDF]

This study aims to assess the role of market structure in the pricing behaviour and profitability of Central and Eastern European banks. In order to determine the most important variables related to the banks' pricing behaviour and profitability, we ...
Csaba Móré, Márton Nagy
core  

Noise‐induced reduction and early recovery of superior paraolivary nucleus sound‐offset responses

The Journal of Physiology, EarlyView.
Abstract figure legend Acoustic over‐exposure transiently disrupts auditory temporal processing in mouse superior paraolivary nucleus neurons. In control conditions, neurons exhibit robust sound‐offset (OFF) responses, which are abolished immediately following noise trauma, indicating impaired temporal encoding.
Mihai Stancu, Ezhilarasan Rajaram, Joseph A. Kroeger, Benedikt Grothe, Conny Kopp‐Scheinpflug   +4 more
wiley   +1 more source

SNAP’s Restaurant Meals Program

Journal of Agriculture, Food Systems, and Community Development
The Supplemental Nutrition Assistance Program (SNAP), the largest U.S. nutrition assistance pro­gram, provides financial support to Americans with low income to purchase food.
Vicky Vong, Cerra Antonacci, Audrey Thomas, Lisa Poirier, Megan Mueller, Julia Wolfson, Yeeli Mui   +6 more
doaj   +3 more sources

Investigation of transient heat flux redistribution caused by rotating n = 2 RMP in ELM mitigation experiments on EAST

Nuclear Fusion
This study investigates the role of rotating n = 2 resonant magnetic perturbation (RMP) in modifying the transient heat flux distribution during edge localized mode (ELM) mitigation on Experimental Advanced Superconducting Tokamak.
G.T. Chen, H. Yang, Y.W. Sun, M.N. Jia, Q. Ma, J.H. Yang, Q.Q. Yang, T.H. Wang, J.Z. Shi, Y.N. Zhang, H. Sheng, X.M. Wu, S. Gu, Z.D. Yang, R.R. Liang, F.C. Zhong   +15 more
doaj   +1 more source

Stac2 genetic deletion alters mouse chromaffin cells’ CaV channel composition, increases membrane excitability and reduces vesicle exocytosis

The Journal of Physiology, EarlyView.
Abstract figure legend Stac2 adaptor protein is expressed in neurons and endocrine cells. Using a global Stac2 knockout mouse model here we investigated the role of endogenous Stac2 in adrenal gland mouse chromaffin cell (MCC) excitability and catecholamine vesicle exocytosis.
Stefanie M. Geisler, Noelia Jacobo‐Piqueras, Tamara Theiner, Ryoichi S. Taguchi, Laura E. Häfele, Marta Campiglio, Petronel Tuluc   +6 more
wiley   +1 more source