Results 81 to 90 of about 20,565 (264)

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

Rawlins RMP Biological Assessment [PDF]

, 1998
This Biological Assessment (BA) is prepared for the Draft Environmental Impact Statement (DEIS) that describes the comprehensive analysis of alternatives for the planning and management of public lands and resources administered by the Bureau of Land ...
Bureau of Land Management
core   +1 more source

Effect of rice microgreen powder and microbial transglutaminase on the baking characteristics, microstructure and functional properties of sponge cake

Applied Food Research
Increasing consumer interest in foods that deliver health benefits has driven the development of functional versions of widely consumed products such as cakes. This study evaluated the effects of substituting rice microgreen powder (RMP) for wheat flour (
Hossein Jooyandeh, Behrooz Alizadeh Behbehani, Sara Saniee   +2 more
doaj   +1 more source

3D Nanoprinted Structures Promote Robust Integration of Brain Organoids into Topography‐Guided Neuronal Networks

Small, EarlyView.
Dedicated cultivation platforms facilitate the implementation of brain organoids in guided neuronal networks. Fabrication is enabled by two‐photon polymerization‐based 3D nanoprinting (3DN) and allows for cultivation in standard 12‐well plates. Fine features, namely slopes, funnels, rods, steps, and walls, facilitate and promote organoid positioning ...
Malte Siegmund, Tobias Müller, Emma Wollesen, Kim Krieg, Jack Muse, Jan Hahn, Maya Luongo, Wolfgang J. Parak, Ole Pless, Robert Zierold, Robert H. Blick   +10 more
wiley   +1 more source

Risk Management Plan: Expert Review of Applications for Marketing Authorisation in the EAEU Depending on the Type of Medicinal Product (Review)

Безопасность и риск фармакотерапии
INTRODUCTION. A risk management plan (RMP) is an important document for assessing and managing risks when using a medicinal product. An RMP is provided as part of the marketing authorisation application for a medicinal product.
T. M. Bukatina, E. V. Shubnikova
doaj   +1 more source

Multifaceted Behavior and Versatility Features of Ferritic Stainless Steels, Part II: Investigating Electromagnetic, Mechanical, and Corrosion Behavior

steel research international, EarlyView.
This review's second part details the mechanical, corrosion, and electromagnetic behaviors of FSSs. It integrates the foundational microstructure (texture/defects/precipitates) and processing effects from Part I to establish and analyze complex property–property interrelationships critical for high‐performance applications.
Shahab Bazri, Carlo Mapelli, Davide Mombelli   +2 more
wiley   +1 more source

Oxidative Damage, Energy Imbalance, and Behavioral Disruptions in Girardia tigrina Exposed to Treated Sewage Effluents

Environmental Toxicology, EarlyView.
ABSTRACT This study assessed the ecotoxicological effects of treated sewage on the freshwater planarian Girardia tigrina, integrating biochemical, energetic, and behavioral biomarkers. Planarians were exposed for 48 h to different concentrations of treated sewage (12.5%, 25%, 50%, and 100%) and compared to controls using commercial water and water from
Renata M. P. Freitas, Pedro H. Carvalho, Daniela de Melo e Silva, Carlos Gravato   +3 more
wiley   +1 more source

Improving tumor marker comparability: A case series on harmonizing carbohydrate antigen 19‐9 and carbohydrate antigen 15‐3 measurements across diverse measurement systems

VIEW, EarlyView.
CA19‐9 and CA15‐3 measurements from seven contemporary immunoassay systems were compared using 464 and 499 native serum samples, respectively. Inter‐system correlations were higher for CA15‐3 than for CA19‐9, and only a limited number of systems met biological variation‐derived bias criteria.
Jia Li, Xiaoying Lou, Zongdan Wang, Mengdi Wu, Jing Zhang, Huishuang Gao, Meng Li, Bing Wu, Dongmei Ma, Kuo Zhang, Wei Cui   +10 more
wiley   +1 more source

Parasites at the Summit: Unexpected Geographic Distribution of the Blood Parasite Lineage Found in the Endangered Giant Lizard of Tenerife

Integrative Zoology, EarlyView.
We combined microscopic screening and molecular phylogenetic analyses to characterize blood parasites infecting Gallotia intermedia from the coastal cliffs of Montaña de Guaza and to place these infections in a broader biogeographic context. We detected apicomplexan parasites of the genus Karyolysus infecting 53.6% of G.
Rodrigo Megía‐Palma, Gonzalo Albaladejo‐Robles, Gemma Palomar, Javier Martínez, Anamarija Žagar, Alejandro Escánez‐Pérez, Miguel A. Carretero, Wiesław Babik, Santiago Merino   +8 more
wiley   +1 more source

Micro‐Nanoplastics Significantly Increase Adverse Events and Economic Burden Associated With Carotid Endarterectomy: A Health Economic Modelling Evaluation

ANZ Journal of Surgery, EarlyView.
Current research reports that micro‐nanoplastics may increase the burden of cardiovascular disease with significant human and economic consequences. The detection of plastic particles in biological matrices is challenging and rigorous research is required to investigate the clinical and broader public health implications of microplastics.
Adrian Goldsworthy, Marcus Randall, Oystein Tronstad, Jacky Suen, John F. Fraser   +4 more
wiley   +1 more source