Results 191 to 200 of about 388,782 (280)

A transfer RNA methyltransferase with an unusual domain composition catalyzes 2'-O-methylation at position 6 in tRNA. [PDF]

Nucleic Acids Res
Matsuda T, Yamagami R, Ihara A, Suzuki T, Hirata A, Hori H.   +5 more
europepmc   +1 more source

METTL3/ALKBH5‐Mediated N6‐Methyladenosine Modification Drives Macrophage M1 Polarization via the SLC15A3‐TASL‐IRF5 Signaling Axis in Psoriasis

Advanced Science, EarlyView.
m6A modification stabilizes Slc15a3 mRNA in macrophages, activating the SLC15A3‐TASL‐IRF5 axis and promoting psoriatic inflammation. Abstract Impaired N6‐methyladenosine (m6A) modification has been implicated in regulating various inflammatory diseases, but its role in psoriasis remains unclear.
Tao Huang, Shijun Chen, Ke Ding, Liyan Yuan, Weiqi Lv, Kechen Chen, Yuchen Liu, Dongzhao Ma, Xin Zhang, Xiaobo Wang, Guanzheng Luo, Bin Yang, Ying Lin, Zhili Rong   +13 more
wiley   +1 more source

Evolutionary Origins and Functional Diversification of 2'-O-Methyltransferases: Insights from Phylogenetic and Structural Analysis. [PDF]

Int J Mol Sci
Wang SN, Liu XX, Lei LJ, Wang Q, Shao ZQ, Liu Y.   +5 more
europepmc   +1 more source

Catalytic Hairpin Assembly‐Propelled Weak‐Inputs‐Strong‐Outputs (CP‐WISO) DNA Logic Nanodevices with Orthogonal Design and Contrary Logic Responses

Advanced Science, EarlyView.
Catalytic hairpin assembly‐propelled weak‐inputs‐strong‐outputs (CP‐WISO) DNA logic nanodevices with orthogonal design and contrary logic responses are innovatively fabricated. Moreover, the even and odd parity generators/checkers for ensuring normal molecular data transmission, and the logic‐programmed miRNA biosensors with ratiometric fluorescent ...
Xujuan Lv, Jiawen Han, Juan Wang, Zhihua Lv, Baojian Huang, Shuai Qin, Xuxin Yan, Shaojun Dong, Daoqing Fan   +8 more
wiley   +1 more source

Endogenous Ribonucleases: Therapeutic Targeting of the Transcriptome Through Oligonucleotide-Triggered RNA Inactivation. [PDF]

Biomolecules
Chiglintseva DA, Patutina OA, Zenkova MA.   +2 more
europepmc   +1 more source

Inhibition and Rescue of Hyperglycemia‐Induced Cellular Senescence by Mitochondrial Transfer from Enucleated Mesenchymal Stem Cell‐Derived Microvesicles for Chronic Wound Healing

Advanced Science, EarlyView.
This study develops enucleated MSC‐derived microvesicles (Mito@euMVs) to deliver functional mitochondria for optimizing wound repair. By efficiently encapsulating mitochondria, Mito@euMVs rejuvenate hyperglycemia‐induced senescent fibroblasts and HUVECs. Using PVA microneedle patches, the therapeutic efficacy of Mito@euMVs is validated in diabetic rats
Zixuan Dong, Xiaobing Liu, Shichun Li, Xiaoling Fu   +3 more
wiley   +1 more source

The coming of age of DNA-based catalysts for therapeutic applications. [PDF]

Clin Transl Med
Hesse R, Gertzen CGW, Schmuck JF, Böcker JD, Pandey P, Behn T, Ruth C, Riesner D, Kath-Schorr S, Lang PA, Gohlke H, Etzkorn M.   +11 more
europepmc   +1 more source

Human Schlafen 14 Cleavage of Short Double‐Stranded RNAs Underpins its Antiviral Activity

Advanced Science, EarlyView.
SLFN14 is associated with human diseases. SLFN14 is found to cleave RNAs containing short duplexes. The cryo‐EM structures of SLFN14 and SLFN14‐hairpin RNA complex reveal that SLFN14 assembles into a ring‐like dimer; two RNase domains form an RNA‐binding groove accommodating a hairpin RNA.
Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui   +8 more
wiley   +1 more source

Decoupling Global and Local Structural Changes in Self-aminoacylating Ribozymes Reveals the Critical Role of Local Structural Dynamics in Ribozyme Activity. [PDF]

JACS Au
Cheng YK, Chu HH, Yang NJ, Lai YC.
europepmc   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source