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Site-Selective Modification and Labeling of Native RNA. [PDF]
ChemistryKha TK, Zhao Y, Zhu RY.
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Mechanisms of catalytic RNA molecules
Biochemical Society Transactions, 2021Ribozymes are folded catalytic RNA molecules that perform important biological functions. Since the discovery of the first RNA with catalytic activity in 1982, a large number of ribozymes have been reported. While most catalytic RNA molecules act alone, some RNA-based catalysts, such as RNase P, the ribosome, and the spliceosome, need protein ...
Dulce Alonso, Alfonso Mondragón
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The structure and function of catalytic RNAs [PDF]
Science in China Series C: Life Sciences, 2009 Before the discovery of ribozymes, RNA had been proposed to function as a catalyst, based on the discovery that RNA folded into high-ordered structures as protein did. This hypothesis was confirmed in the 1980s, after the discovery of Tetrahymena group I intron and RNase P ribozyme.
Lin Huang, Qi-Jia Wu, Yi Zhang
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The catalytic diversity of RNAs
Nature Reviews Molecular Cell Biology, 2005The natural RNA enzymes catalyse phosphate-group transfer and peptide-bond formation. Initially, metal ions were proposed to supply the chemical versatility that nucleotides lack. In the ensuing decades, structural and mechanistic studies have substantially altered this initial viewpoint.
Martha J. Fedor, James R. Williamson
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RNA cleavage by small catalytic RNAs
Current Opinion in Structural Biology, 1995Recent studies of the hammerhead ribozyme have provided an insight into its three-dimensional structure. In addition, studies using chemical probes, functional-group modification and mutational analysis, in combination with computer modelling, have led to proposals for the structure of both the hairpin and hepatitis delta virus ribozymes.
James B. Thomson +2 more
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In vitro selection of catalytic RNAs
Current Opinion in Structural Biology, 1994In vitro selection techniques are poised to allow a rapid expansion of the study of catalysis by RNA enzymes (ribozymes). This truly molecular version of genetics has already been applied to the study of the structures of known ribozymes and to the tailoring of their catalytic activity to meet specific requirements of substrate specificity or reaction
Karen B. Chapman, Jack W. Szostak
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The FASEB Journal, 1993
We describe the structures and catalytic properties of several naturally occurring self-cleaving RNA motifs that give 2', 3' cyclic phosphate products. The hammerhead and hairpin motifs are derived from plant pathogenic RNAs and the delta motif is part of the human hepatitis delta element. A fourth motif from Neurospora is less well characterized.
David M. Long, Olke C. Uhlenbeck
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We describe the structures and catalytic properties of several naturally occurring self-cleaving RNA motifs that give 2', 3' cyclic phosphate products. The hammerhead and hairpin motifs are derived from plant pathogenic RNAs and the delta motif is part of the human hepatitis delta element. A fourth motif from Neurospora is less well characterized.
David M. Long, Olke C. Uhlenbeck
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Annual Review of Biochemistry, 1992
PERSPECTIVES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 641 ROLLING CIRCLE REPLICATION REQUIRES SPECIFIC RNA CLEAVAGE . . . . . . . 643 SELF-CLEAVAGE OF RNA VIA THE HAMMERHEAD STRUCTURE.. . . . . . . . . . . . . . .
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PERSPECTIVES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 641 ROLLING CIRCLE REPLICATION REQUIRES SPECIFIC RNA CLEAVAGE . . . . . . . 643 SELF-CLEAVAGE OF RNA VIA THE HAMMERHEAD STRUCTURE.. . . . . . . . . . . . . . .
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Mitochondrial Targeting of Catalytic RNAs
2015Genetic transformation of mitochondria in multicellular eukaryotes has remained inaccessible, hindering fundamental investigations and applications to gene therapy or biotechnology. In this context, we have developed a strategy to target nuclear transgene-encoded RNAs into mitochondria in plants.
Jan Barciszewski +8 more
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