Results 221 to 230 of about 408,201 (235)

Transcriptomics insights into the functional role of tick Ixodes ricinus proteins metalloprotease and antigen p23. [PDF]

PLoS One
Vaz-Rodrigues R, Duru VC, Nijhof AM, de la Fuente J.   +3 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Comparative Transcriptomics Reveals the Molecular Basis for Inducer-Dependent Efficiency in Gastrodin Propionylation by <i>Aspergillus oryzae</i> Whole-Cell Biocatalyst. [PDF]

Biomolecules
Wu D, Ma M, Liu X, Li X, Zhao G.
europepmc   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

An Isothermal Deoxyribozyme Sensor for Rapid Detection of Enteroviral RNA. [PDF]

Biosensors (Basel)
Şaş B, Kirichenko AD, Kapitonova MA, Shabalina AV, Kanaeva OI, El-Messery TM, Dedkov VG, Dolgova AS.   +7 more
europepmc   +1 more source

An Engineered Solidified Peptide Hemocyte Sponge as Nanomotor Storage to Combat Bacterial Colitis

Advanced Science, EarlyView.
Peptides immobilized via nickel coordination can stabilize the framework structure. Following coating with red blood cell membranes, these constructs are capable of continuously sequestering endotoxins and mitigating colonic pathogenic damage by alleviating bacterial‐induced ferroptosis.
Yuxin Fang, Jianming Yan, Tongxin Yu, Zichuan An, Kaikai Lv, Chenyu Xue, Hongyang Yu, Na Dong, Anshan Shan   +8 more
wiley   +1 more source

Intrinsically disordered region of Clr4/Suv39 regulates its enzymatic activity and ensures heterochromatin spreading. [PDF]

Nucleic Acids Res
Nakamura R, Hayashi A, Nakagawa R, Yoshimura Y, Horikoshi N, Kurumizaka H, Nakayama JI.   +6 more
europepmc   +1 more source

Foot-and-mouth disease virus 3C protease as virulence determinant plays multiple roles in cleaving viral polyprotein and host factors. [PDF]

Virulence
Zhou H, Wang M, Xin Z, Li Z, Wang Q, Li Y, Liu F.   +6 more
europepmc   +1 more source

METTL3 uncouples chromatin accessibility from transcription during retinal development. [PDF]

Stem Cell Reports
Xu J, Huang Y, Han Z, Li Q, Liu J, Rao RC.   +5 more
europepmc   +1 more source

Argonaute-mediated RNA editing selectively repairs point mutations. [PDF]

Nucleic Acids Res
Zhang Z, Wang J, Guo T, Yu X, Wang F, Zhang H, Liu Y, Li W, Cheng Y, Peng Y, Yan G, Cui J, Ma L.   +12 more
europepmc   +1 more source