Results 251 to 260 of about 388,782 (280)
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The catalytic diversity of RNAs
Nature Reviews Molecular Cell Biology, 2005The natural RNA enzymes catalyse phosphate-group transfer and peptide-bond formation. Initially, metal ions were proposed to supply the chemical versatility that nucleotides lack. In the ensuing decades, structural and mechanistic studies have substantially altered this initial viewpoint.
Martha J. Fedor, James R. Williamson
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RNA cleavage by small catalytic RNAs
Current Opinion in Structural Biology, 1995Recent studies of the hammerhead ribozyme have provided an insight into its three-dimensional structure. In addition, studies using chemical probes, functional-group modification and mutational analysis, in combination with computer modelling, have led to proposals for the structure of both the hairpin and hepatitis delta virus ribozymes.
James B. Thomson +2 more
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In vitro selection of catalytic RNAs
Current Opinion in Structural Biology, 1994In vitro selection techniques are poised to allow a rapid expansion of the study of catalysis by RNA enzymes (ribozymes). This truly molecular version of genetics has already been applied to the study of the structures of known ribozymes and to the tailoring of their catalytic activity to meet specific requirements of substrate specificity or reaction
Karen B. Chapman, Jack W. Szostak
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The FASEB Journal, 1993
We describe the structures and catalytic properties of several naturally occurring self-cleaving RNA motifs that give 2', 3' cyclic phosphate products. The hammerhead and hairpin motifs are derived from plant pathogenic RNAs and the delta motif is part of the human hepatitis delta element. A fourth motif from Neurospora is less well characterized.
David M. Long, Olke C. Uhlenbeck
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We describe the structures and catalytic properties of several naturally occurring self-cleaving RNA motifs that give 2', 3' cyclic phosphate products. The hammerhead and hairpin motifs are derived from plant pathogenic RNAs and the delta motif is part of the human hepatitis delta element. A fourth motif from Neurospora is less well characterized.
David M. Long, Olke C. Uhlenbeck
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Annual Review of Biochemistry, 1992
PERSPECTIVES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 641 ROLLING CIRCLE REPLICATION REQUIRES SPECIFIC RNA CLEAVAGE . . . . . . . 643 SELF-CLEAVAGE OF RNA VIA THE HAMMERHEAD STRUCTURE.. . . . . . . . . . . . . . .
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PERSPECTIVES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 641 ROLLING CIRCLE REPLICATION REQUIRES SPECIFIC RNA CLEAVAGE . . . . . . . 643 SELF-CLEAVAGE OF RNA VIA THE HAMMERHEAD STRUCTURE.. . . . . . . . . . . . . . .
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Mitochondrial Targeting of Catalytic RNAs
2015Genetic transformation of mitochondria in multicellular eukaryotes has remained inaccessible, hindering fundamental investigations and applications to gene therapy or biotechnology. In this context, we have developed a strategy to target nuclear transgene-encoded RNAs into mitochondria in plants.
Jan Barciszewski +8 more
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The Catalytic Mechanism of RNA Polymerase II
Journal of Chemical Theory and Computation, 2011Eukaryotic RNA polymerase II (RNAP II) transcribes the DNA into mRNA. The presence of two metal ions (usually Mg(2+)) and conserved aspartate residues in the active sites of all nucleic acid polymerases led to the adoption of a universal catalytic mechanism, known as the "two metal ion catalysis".
Maria J. Ramos +2 more
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Catalytic RNA: Structure and Mechanism
Biochemical Society Transactions, 1993The Hopkins Lecturer is given the charge of explaining how advances in other fields of science have had an impact on his or her own field of biochemistry. A moment’s thought revealed that it was not at all difficult to think of examples where other scientific fields have provided necessary groundwork for the study of RNA catalysis or RNA biochemistry ...
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Catalytic RNA and the origin of genetic systems
Trends in Genetics, 1990The recent discovery of catalytic RNA molecules has provoked enormous interest in the origin of life and has given rise to new speculations about how living systems developed on the primitive earth. Here we outline why the discovery of catalytic RNA molecules has profound evolutionary implications, and then go on to discuss models for the emergence of ...
Lamond, Angus I., Gibson, Toby J.
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2015
This chapter looks at how RNA molecules catalyse chemical reactions, a domain which was previously thought to be reserved only for proteins. It clarifies that RNA has a more limited set of functional groups for building catalysts, which are confined to just four different nucleotides: A, C, G, and U.
David Elliott, Michael Ladomery
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This chapter looks at how RNA molecules catalyse chemical reactions, a domain which was previously thought to be reserved only for proteins. It clarifies that RNA has a more limited set of functional groups for building catalysts, which are confined to just four different nucleotides: A, C, G, and U.
David Elliott, Michael Ladomery
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