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Recent insights on RNA folding mechanisms from catalytic RNA
Cellular and Molecular Life Sciences (CMLS), 2000Methods for probing RNA structure in real time have revealed that initial folding steps are complete in less than a second. Refolding of large catalytic RNAs in vitro often results in long-lived intermediates that reach the native structure very slowly.
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Catalytic RNA reactions of yeast tRNAPhe fragments
Biochemistry, 1992We describe 12 new catalytic RNA reactions which are intermolecular variants of the well-known intramolecular Pb(2+)-promoted hydrolysis of yeast tRNA(Phe). Fragments derived from the native yeast tRNA(Phe) which possess the T stem-loop can function as catalysts for the site-specific hydrolysis at p18 of D stem-loop-containing fragments.
H Y, Deng, J, Termini
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Amplification, mutation and selection of catalytic RNA
Gene, 1989RNA, by virtue of its genotypic and phenotypic properties, is a suitable substrate for molecular evolution in the laboratory. We have developed techniques for the rapid amplification, mutation and selection of catalytic RNA. By combining these techniques in an iterative fashion, we are attempting to construct an RNA-based evolving system. Such a system
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Metal ion binding to catalytic RNA molecules
Current Opinion in Structural Biology, 2003Cations play critical roles in ribozyme structure and catalysis. Unraveling the contributions of cations as catalytic cofactors is a complex process, due to their role in inducing RNA folding and their potential ability to influence chemical reactions. Recent studies have made progress in separating these roles by directly comparing ion-induced folding
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Investigating catalytic RNA molecules
Collection Symposium Series, 2002Svetomir B. Tzokov +3 more
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