Results 101 to 110 of about 5,336 (124)

New insights into glioma frequency maps: From genetic and transcriptomic correlate to survival prediction

International Journal of Cancer, Volume 152, Issue 5, Page 998-1012, 1 March 2023., 2023
What's new? The spatial distribution of glioma is nonrandom. However, whether pathological grade influences glioma distribution across the brain remains unclear. Here, the authors built a population‐based frequency map for 396 patients with glioblastoma multiforme and 190 patients with lower‐grade glioma, revealing their distinct topographic ...
Hongbo Bao, Peng Ren, Liye Yi, Zhonghua Lv, Wencai Ding, Chenlong Li, Siyang Li, Zhipeng Li, Xue Yang, Xia Liang, Peng Liang   +10 more
wiley   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Over two decades of research on the marine RNA virosphere

iMeta, Volume 1, Issue 4, December 2022., 2022
Advances in meta‐omics provide a surge of marine RNA virus information. Deep marine virus discovery contributes greatly to the megataxonomy of RNA viruses. Understanding diversity and biogeography helps reveal the significance of marine RNA viruses, including evolutionary trajectories, hierarchical taxonomy, and ecological importance.
Meng‐en Liao, Yunyi Xie, Mang Shi, Jie Cui   +3 more
wiley   +1 more source

Progress and challenges of mRNA vaccines

Interdisciplinary Medicine, Volume 1, Issue 1, January 2023., 2023
As the third‐generation nucleic acid vaccine, the Messenger RNA (mRNA) vaccine stimulates a specific immune response by introducing mRNA expressing the target antigen into the body through a specific delivery system and expressing the corresponding protein.
Liangru Lin, Yusheng Pei, Zhou Li, Dan Luo   +3 more
wiley   +1 more source

Breaking barriers: Smart vaccine platforms for cancer immunomodulation

Cancer Communications, EarlyView.
Abstract Despite significant advancements in cancer treatment, current therapies often fail to completely eradicate malignant cells. This shortfall underscores the urgent need to explore alternative approaches such as cancer vaccines. Leveraging the immune system's natural ability to target and kill cancer cells holds great therapeutic potential ...
Mohammad Mahmoudi Gomari, Taha Ghantabpour, Nima Pourgholam, Neda Rostami, Stephen M. Hatfield, Farzaneh Namazifar, Shadi Abkhiz, Seyed Sadegh Eslami, Mahsa Ramezanpour, Mahsa Darestanifarahani, Igor Astsaturov, Sidi A. Bencherif    +11 more
wiley   +1 more source

Osteocyte Estrogen Receptor β (Ot‐ERβ) Regulates Bone Turnover and Skeletal Adaptive Response to Mechanical Loading Differently in Male and Female Growing and Adult Mice

Journal of Bone and Mineral Research, Volume 38, Issue 1, Page 186-197, January 2023., 2023
ABSTRACT Age‐related bone loss is a failure of balanced bone turnover and diminished skeletal mechanoadaptation. Estrogen receptors, ERα and ERβ, play critical roles in osteoprotective regulation activated by estrogen and mechanical signals. Previous studies mainly focused on ERα and showed that osteocyte‐ERα (Ot‐ERα) regulated trabecular, but not ...
Xiaoyu Xu, Haisheng Yang, Whitney A. Bullock, Maxim A. Gallant, Claes Ohlsson, Teresita M. Bellido, Russell P. Main   +6 more
wiley   +1 more source

Enhancing antitumor immunity through the combination of cholesterolized TLR7 agonist liposomes and radiotherapy: a role for IL‐1β and the inflammasome pathway

Cancer Communications, EarlyView.
Abstract Background Radiotherapy (RT) is a key treatment modality in cancer therapy, utilizing high‐energy radiation to directly kill tumor cells. Recent research has increasingly highlighted RT's potential to indirectly enhance antitumor immunity. However, this immune activation alone often fails to generate sustained systemic antitumor responses.
Xuejiao Han, Yuan Cheng, Dandan Wan, Aqu Alu, Ziqi Zhang, Zhenfei Bi, Manni Wang, Yan Tang, Weiqi Hong, Siyuan Chen, Li Chen, Yuquan Wei   +11 more
wiley   +1 more source

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, EarlyView.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

Effects of glepaglutide, a long‐acting glucagon‐like peptide‐2 analog, on intestinal morphology and perfusion in patients with short bowel syndrome: Findings from a randomized phase 2 trial

Journal of Parenteral and Enteral Nutrition, Volume 47, Issue 1, Page 140-150, January 2023., 2023
Abstract Background The proadaptive effects of glucagon‐like peptide‐2 (GLP‐2) include stimulation of intestinal mucosal growth as well as intestinal blood flow and angiogenesis. We have recently reported that daily subcutaneous injections of glepaglutide, a long‐acting GLP‐2 analog, improved intestinal absorptive function in patients with short bowel ...
Rahim M. Naimi, Mark K. Hvistendahl, Steen S. Poulsen, Hannelouise Kissow, Jens Pedersen, Nikolaj A. Nerup, Rikard Ambrus, Michael P. Achiam, Lars B. Svendsen, Palle B. Jeppesen   +9 more
wiley   +1 more source

Comparative proteome analysis of the ligamentum flavum of patients with lumbar spinal canal stenosis

JOR SPINE, Volume 5, Issue 4, December 2022., 2022
This study investigated the pathology of thickened ligamentum flavum in patients with lumbar spinal canal stenosis (LSCS) based on protein expression levels using shotgun proteome analysis. The results showed that tissue repair via fibrosis, chondrometaplasia, and amyloid deposits may be important pathologies that occur in the thickened ligamentum ...
Yutaka Yabe, Yoshihiro Hagiwara, Masahiro Tsuchiya, Takashi Minowa, Taro Takemura, Shinya Hattori, Shinichirou Yoshida, Takahiro Onoki, Keisuke Ishikawa   +8 more
wiley   +1 more source