Results 101 to 110 of about 1,540,463 (333)
The potential role of RNA N6-methyladenosine in Cancer progression
Molecular Cancer, 2020 N6-methyladenosine (m6A) is considered the most common, abundant, and conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA).
Tianyi Wang, S. Kong, Mei Tao, S. Ju
semanticscholar +1 more source
The Identification of Collagen Messenger RNA [PDF]
Proceedings of the National Academy of Sciences, 1974 RNA isolated from calvaria of 16- to 18- day-old chick embryos, assayed in rabbit reticulocyte lysates, programs the synthesis of a collagenase-sensitive protein with the molecular weight of collagen pro-α-chains. When RNA labeled with [ 3 H]uridine for 2 hr and chased for 1 or 2 hr was electrophoresed on aqueous ...
H, Boedtker +3 more
openaire +3 more sources
Rolling Ultrasharp Microneedle Spheres Enable Topical Delivery of Biologics Through the Skin
Advanced Healthcare Materials, EarlyView.Rolling ultraminiaturized microneedle spheres (RUMS), created via two‐photon polymerization, unlock effective and painless topical delivery of messenger RNA (mRNA) and drugs through the skin. By gently forming thousands of microscopic pores, RUMS boost skin permeability by up to 100‐fold.
Theocharis Nikiforos Iordanidis +6 more
wiley +1 more source
Equilibrium Properties of Mouse-Torpedo Acetylcholine Receptor Hybrids Expressed in Xenopus Oocytes [PDF]
, 1987 This study used messenger RNA encoding each subunit (α, β, γ and δ) of the nicotinic acetylcholine (ACh) receptor from mouse BC3H-1 cells and from Torpedo electric organ.
Davidson, Norman +4 more
core +3 more sources
Science, 2020 A new layer of transcriptional control N6-methyladenosine (m6A) is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m6A is also cotranscriptionally added onto various chromosome-associated regulatory RNAs ...
Jun Liu +10 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz +2 more
wiley +1 more source
In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus. [PDF]
, 2015 Viruses in the Reoviridae, like the triple-shelled human rotavirus and the single-shelled insect cytoplasmic polyhedrosis virus (CPV), all package a genome of segmented double-stranded RNAs (dsRNAs) inside the viral capsid and carry out endogenous ...
Chang, Winston +5 more
core
Origin of symbol-using systems: speech, but not sign, without the semantic urge [PDF]
, 2014 Natural language—spoken and signed—is a multichannel phenomenon, involving facial and body expression, and voice and visual intonation that is often used in the service of a social urge to communicate meaning.
Alberts B +27 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.The therapeutic efficacy of lipid nanoparticle(LNP)‐based drugs depends on endosomal escape. However, few methods are available for quantifying the efficiency of endosomal escape in vivo. Herein, a novel method for quantifying the endosomal escape efficiency index using magnetic resonance imaging is introduced.
Somin Lee +5 more
wiley +1 more source
Intracellular Chloride Concentration Changes Modulate IL-1β Expression and Secretion in Human Bronchial Epithelial Cultured Cells [PDF]
, 2017 Cystic fibrosis (CF) is caused by mutations in the CFTR gene, which encodes a cAMP‐regulated chloride channel. Several cellular functions are altered in CF cells. However, it is not clear how the CFTR failure induces those alterations.
Clauzure, Mariangeles +6 more
core +1 more source