Results 111 to 120 of about 5,336 (124)

A Fluorescent Aptasensor for Sensitive and Selective Determination of Epigenetic Cancer Biomarker N1‐Methyladenosine in Urine Samples

Chemistry – A European Journal, EarlyView.
Using N1‐methyladenosine, a cancer biomarker as a target, a highly selective DNA aptamer was obtained with excellent selectivity and affinity, allowing the detection with a limit of detection of 1.9 µm. Abstract N1‐methyladenosine (m1A) level in urine increases in the presence of cancer and is associated with the tumor size and stage.
Esra Bağda, Efkan Bağda, Juewen Liu
wiley   +1 more source

Advancements in the Application of the Intersection of Medicine and Engineering in Cancer Research

Cancer Nexus, EarlyView.
ABSTRACT Cancer research predominantly centers on diagnosis, treatment, and elucidation of underlying mechanisms. Nevertheless, the intricate nature of tumor genesis and development has rendered early diagnostic and therapeutic outcomes less than optimal, making tumor conquest a formidable challenge.
Haitao Chen, Guanmeng Zhang, Yuping Qian, Yang Peng, Xiaoli Li, Jiawen Wang, Jinlan Wang, Yuxiang Hu, Han Xiao, Qinqiu Zhong, Xin Li, Yumeng Xie, Yukun Chen, Lijun Zhao, Qiqi Jing, Xiaofeng Shan, Yuguang Wang   +16 more
wiley   +1 more source

Advances in Isotope Labeling for Solution Nucleic Acid NMR Spectroscopy

ChemPlusChem, Accepted Article.
The availability of nucleic acid structural biology methods still lags behind that of proteins, as evidenced by the significantly smaller number of structures deposited in the PDB. The highly skewed ratio of nucleic acid structures, relative to their protein counterparts (~1:50), is inverted with respect to the cellular output of RNA and proteins in ...
Stefan Hilber, Solomon Kojo Attionu, Theodore Kwaku Dayie, Christoph Kreutz   +3 more
wiley   +1 more source

Autopsy findings in cases of fatal COVID‐19 vaccine‐induced myocarditis

ESC Heart Failure, EarlyView.
Abstract COVID‐19 vaccines have been linked to myocarditis, which, in some circumstances, can be fatal. This systematic review aims to investigate potential causal links between COVID‐19 vaccines and death from myocarditis using post‐mortem analysis.
Nicolas Hulscher, Roger Hodkinson, William Makis, Peter A. McCullough   +3 more
wiley   +1 more source

Discovery of miRNAs unique to actively transcribed erythroparvovirus infection in heart failure patients

ESC Heart Failure, EarlyView.
Abstract Aims miRNAs, small non‐coding RNAs, play key roles in gene regulation, cell differentiation and tissue development. They influence viral infection outcomes by directly interacting with viral genomes or modifying the host microenvironment. This study demonstrates miRNAs' ability to selectively suppress transcriptionally active erythroparvovirus,
Ganna Aleshcheva, Sara Salih, Christian Baumeier, Felicitas Escher, C. Thomas Bock, Heinz‐Peter Schultheiss   +5 more
wiley   +1 more source

Unlocking the power of empagliflozin: Rescuing inflammation in hyperglycaemia‐ exposed human cardiomyocytes through comprehensive multi‐level analysis

European Journal of Heart Failure, EarlyView.
Schematic representation of the study workflow, pathological model, experimental workflow, and key findings deriving from the integration of clinical trials, public databases, and the cellular model. SGLT2‐i, sodium–glucose cotransporter 2 inhibitor; T2D, type 2 diabetes.
Rosaria Benedetti, Ugo Chianese, Chiara Papulino, Lucia Scisciola, Mirko Cortese, Pietro Formisano, Nunzio Del Gaudio, Serena Cabaro, Vittoria D'Esposito, Ada Pesapane, Mariarosaria Conte, Giuseppe Signoriello, Michelangela Barbieri, Lucia Altucci, Giuseppe Paolisso   +14 more
wiley   +1 more source

A Comprehensive Review on Capillary Electrophoresis–Mass Spectrometry in Advancing Biomolecular Research

ELECTROPHORESIS, EarlyView.
ABSTRACT This review provides an in‐depth exploration of capillary electrophoresis–mass spectrometry (CE–MS) in biomolecular research from 2020 to 2024. CE–MS emerges as a versatile and powerful tool due to its numerous advantages, facilitating the analysis of various biomolecules, including proteins, peptides, oligonucleotides, and other metabolites ...
Laura Pont, María Vergara‐Barberán, Enrique Javier Carrasco‐Correa   +2 more
wiley   +1 more source

A Comprehensive Evaluation of Analytical Method Parameters Critical to the Reliable Assessment of Therapeutic mRNA Integrity by Capillary Gel Electrophoresis

ELECTROPHORESIS, EarlyView.
ABSTRACT In recent years, messenger ribonucleic acid (mRNA)‐lipid nanoparticle (LNP) biotherapeutics have demonstrated significant promise in disease treatment and prevention given their rapidly modifiable production processes and considerable capacity to adapt to complex or low‐yielding proteins of interest.
Jessica P. Tran, Jun Gao, Casey Lansdell, Barry Lorbetskie, Michael J. W. Johnston, Lisheng Wang, Xuguang Li, Huixin Lu   +7 more
wiley   +1 more source

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

Berries: Health Effects via Modulation of the Gut Microbiota

Food Frontiers, EarlyView.
ABSTRACT Berries are widely regarded as beneficial foods, rich in polyphenols, flavonoids, and other bioactive compounds that could positively influence human health. Although the gut microbiota plays a crucial role in metabolism and physiology of humans, the interaction between berries and human gut microbiota activity remains unclear.
Manjin Xu, Yunfeng Xu, Lizhi Wu, Huixia Niu, Bei Gao, Kai Sun, Xueqing Li, Mingluan Xing, Zhe Mo, Zhijian Chen, Pengcheng Tu, Xiaoming Lou   +11 more
wiley   +1 more source