Results 141 to 150 of about 1,216,475 (294)

Polyphosphate Copper Nanospheres Drive Mitochondrial Metabolic Reprogramming via Calcium Phase Separation for Self‐Sensitizing Cuproptosis

Advanced Science, EarlyView.
This study developed polyphosphate (polyP)‐based nanostructures that enable calcium‐mediated metabolic reprogramming via liquid–liquid phase separation (LLPS). Released polyP undergoes LLPS with Ca2+, suppressing glycolytic flux and enhancing mitochondrial metabolism effectively.
Jing Wang, Xinyang Zhao, Zifeng Huang, Jingyi Zhang, Yucheng Tao, Yong Huang, Zijian Guo, Lei Dong, Xiuxiu Wang, Jing Zhao, Wei Wei   +10 more
wiley   +1 more source

Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca2+‐CaMKK2‐AMPK Signaling to Counter MASLD

Advanced Science, EarlyView.
In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei, Li Lin, Xiuyun Wang, Hui Du, Menglong Zhang, Kechao Tang, Han Gao, Xinrui Xie, Jingya Gao, Xu Wang, Zhenglin Wang, Siwei Huang, Lei Zhang, Fang Gu, Gong‐Hong Wei, Yinliang Qi, Wei Chen, Yongsheng Chang, Huabing Zhang   +18 more
wiley   +1 more source

Adaptation of a Fluorogenic RNA to N1‐Methylpseudouridine Nucleoside Chemistry

Angewandte Chemie, EarlyView.
Several green‐emitting fluorogenic RNA aptamers were evaluated following the replacement of every uridine by N1‐methylpseudouridine (mΨ). Because this modification impaired the function of most aptamers, a directed evolution strategy combining droplet microfluidics, bioinformatics, and rational design was used to identify an aptamer preserving its ...
Patrick P.A. Bertrand, Roger Cubi, Claire Husser, Magali Frugier, Michael Ryckelynck   +4 more
wiley   +2 more sources

Large Oncosomes Induce Pro‐Metastatic Stromal‐Myeloid Reprogramming

Advanced Science, EarlyView.
Large oncosomes systemically reprogram bone marrow mesenchymal stem cells through innate nucleic acid sensing, driving inflammatory and immunosuppressive remodeling that supports a metastasis‐permissive bone marrow environment, revealing a novel tumor‐host communication axis in cancer. ABSTRACT Bone metastasis can be facilitated by systemic remodeling,
Taylon Felipe Silva, Virginia Marcia Concato‐Lopes, Fatima Bedier, Lauren Newman, Diana Kitka, Jamelle Brown, Blandine Victor, Minhyung Kim, Tatyana Vagner, Catherine Grasso, Dmitriy Sheyn, Sungyong You, Michael R. Freeman, Fayyaz S. Sutterwala, Helen S. Goodridge, Caroline Jefferies, Paola de Candia, Jlenia Guarnerio, Dolores Di Vizio   +18 more
wiley   +1 more source

A long non-coding RNA-messenger RNA regulatory network associated with residual feed intake in the olfactory tissue of meat ducks. [PDF]

Poult Sci
Ruan S, Guo S, Gao C, Cai Z, Xi Y, Han X, Qi J, Li Q, Yang Z, Qieyong Z, Yang X, Huang A, Bai L, Liu H, Li L.   +14 more
europepmc   +1 more source

Biomimetic Nanoplatform for Fibrosis Remodeling and Anti‐PD‐1 Potentiation via Cu+/Ca2+ Ion Dysregulation and TGF‐β Inhibition in PDAC

Advanced Science, EarlyView.
A biomimetic nanoplatform (RPm@CC‐LY) remodels fibrotic stroma via sustained TGF‐β inhibition, triggers oxidative stress and apoptosis through Cu+‐mediated Fenton chemistry and Ca2+ overload, and reprograms macrophages and dendritic cells to boost CD8+ T cell infiltration.
Jianmei Li, Qinlong Wen, Jie Dai, Li Yang, Feng Xiong, Zhigong Wei, Xingchen Peng   +6 more
wiley   +1 more source

Latent messenger RNA in dormant Artemia embryos

, 1980
This thesis deals with the demonstration and partial characterization of latent messenger RNA in encysted Artemia embryos.RNA was extracted from subcellular fractions of dormant Artemia cysts and tested for template activity in a messenger RNA deficient ...
Nilsson, Mats Ola,
core  

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

Carcinoembryonic Antigen Messenger RNA in Pelvic Lavage Fluid Predicts Local Recurrence After Curative‐Intent Resection of Rectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
Pelvic lavage carcinoembryonic antigen (CEA) mRNA was quantified in 178 patients undergoing curative‐intent resection for rectal cancer. Positive pelvic lavage CEA mRNA was significantly associated with local recurrence and provided additional prognostic information beyond circumferential resection margin (CRM) status.
Hiroyuki Asai, Yushi Yamakawa, Kazuyoshi Shiga, Shuhei Uehara, Akira Kato, Takuya Suzuki, Hajime Ushigome, Hiroki Takahashi, Yoichi Matsuo, Shuji Takiguchi   +9 more
wiley   +1 more source

The Lifetime of Bacterial Messenger RNA

, 1963
Puromycin, an inhibitor of protein synthesis, appears to act as an inhibitor at additional sites during the induction of {beta}-galactosidase synthesis. No inhibition of the reactions proceeding during the first 20 seconds of induction was observed, but puromycin seems to prevent the accumulation of messenger RNA during the period between 20 seconds ...
Moses, V., Calvin, M.
openaire   +3 more sources