Results 201 to 210 of about 1,540,463 (333)

Development of an efficient mice model of cancer‐associated cardiac cachexia

Animal Models and Experimental Medicine, EarlyView.
This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong, Huiting Zheng, Teng Wu, Jing Tan, Tongsheng Huang, Conghui Shen, Yuanjun Ji, Mengying Liu, Junhong Wan, Weibin Cai   +9 more
wiley   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Modifying gene expression through passive forces. [PDF]

Elife
Hallstein S, König J.
europepmc   +1 more source

Establishment and molecular profiling of a PDX model of a metachronous brain tumor in a patient with constitutional mismatch repair deficiency with biallelic MSH6 variant

Animal Models and Experimental Medicine, EarlyView.
A 6½‐year‐old girl was diagnosed with a medulloblastoma, SHH activated, subtype 3 and TP53 mutant (somatic). After surgery and chemotherapy, she was monitored with quarterly magnetic resonance imaging (MRI) scans and remained free of disease for almost 4 years.
Daniel Antunes Moreno, Bruna Minniti Mançano, Mirella Baroni, Eric Allison Philot, Felipe Antonio de Oliveira Garcia, Murilo Bonatelli, Flávia Escremim de Paula, Iara Viana Vidigal Santana, Gustavo Ramos Teixeira, Mauricio Yamanari, Luciane Sussuchi da Silva, André Escremim de Paula, Augusto Perazzolo Antoniazzi, Adrian Willig, Xiaobin Xing, Zhenyu Xu, Lucas Lourenço, Carlos Almeida Junior, Silvia Aparecida Teixeira, Rui Manuel Reis   +19 more
wiley   +1 more source

Phenotypic Changes in a Monocyte Cluster with High Interleukin‐1 Beta Expression during Long‐Term Anti‐CD20 Therapy

Annals of Neurology, EarlyView.
Graphical abstract illustrating the study design, experimental workflow, and key findings from single‐cell profiling of peripheral mononuclear cells in multiple sclerosis patients undergoing anti‐CD20 therapy, revealing disease‐ and treatment‐associated immune signatures.
Mie Waede, Christina Kingo, Karina Damsbo, Maiken Uhrbrand Joergensen, Mhaned Oubounyt, Morten Gjerstorff, Mads Thomassen, Jan Baumbach, Jesper B. Moeller, Maria L. Elkjaer, Zsolt Illes   +10 more
wiley   +1 more source

Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer. [PDF]

Elife
Zhang C, Zhang Z, Wu Y, Wu Y, Cheng J, Luo K, Li Z, Zhang M, Wang J, Zhang X, Li Y.   +10 more
europepmc   +1 more source

Potential Application of a Water‐Soluble Fullerene C60 Decorated with Diethylene Glycol in Treatment of Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
A new ethoxyethanol derivative of iminofullerene, F2, is synthesized and labeled with 99mTc to produce 99mTc‐F2. In vitro, compound F2 inhibits the activation of primary mouse bone marrow‐derived macrophages stimulated with lipopolysaccharide. Moreover, 99mTc‐F2 is selectively enriched in the injured joints of mice. Inflammatory macrophages play a role
Rui He, Alyssa Costello, Yanjie Liu, Weicheng Wang, Zhichang Zhang, Quanjun Cui, Xinlin Yang   +6 more
wiley   +1 more source

Elavl1 deletion in limb mesenchyme is dispensable for skeletal morphogenesis. [PDF]

Front Cell Dev Biol
Parsha R, Kota SK.
europepmc   +1 more source

Translation of Synthetic Messenger RNA

Cold Spring Harbor Symposia on Quantitative Biology, 1966
Paul Doty, T. A. Sundararajan, Robert E. Thach, Jay C. Brown, K. F. Dewey   +4 more
openaire   +3 more sources

Endogenously Triggered DNAzyme‐Based Nanostructures for Gene‐Combined Therapy

Advanced NanoBiomed Research, EarlyView.
DNAzymes show great promise for gene regulation and therapeutic use via controlled release triggered by endogenous factors. This review summarizes recent advances in designing and constructing nanoscale platforms enabling endogenously triggered release of DNAzyme.
Theoneste Muyizere, Julien Milon Essola, Eric Nyirimigabo, Janvier Mukiza, Jean Felix Mukerabigwi   +4 more
wiley   +1 more source