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Vaccination With Messenger RNA
2006As an alternative to DNA-based vaccines, messenger RNA (mRNA)-based vaccines present additional safety features: no persistence, no integration in the genome, no induction of autoantibodies. Moreover, mRNA which are generated by in vitro transcription, are easy to produce in large amounts and very high purity.
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Messenger Properties of TYMV-RNA
Virology, 1977Abstract Turnip yellow mosaic virus (TYMV) RNA extracted from virions (“virion” TYMV-RNA) contains two types of molecules of molecular weight 2 × 10 6 : one which resists heat denaturation (“intact” TYMV-RNA) and one which yields smaller fragments upon heat denaturation (TYMV-RNA containing hidden breaks).
B, Ricard +4 more
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Messenger RNA Modifications in Plants
Trends in Plant Science, 2019Over 160 distinct RNA modifications are known and collectively termed the epitranscriptome. Some of these modifications have been discovered in mRNA, uncovering a new layer of gene regulation. Transcriptome-wide mapping of epitranscriptomic codes and the discovery of their writers, erasers, and readers that dynamically install, remove, and interpret ...
Lisha, Shen +3 more
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Radiation sensitivity of messenger RNA
Molecular and General Genetics MGG, 1979Messenger RNA function is inactivated by irradiation with ultraviolet light. A unit length mRNA (in bases) is 2-3 times more sensitive than a unit length of DNA (in base pairs) with respect to the inactivation of template function. These data stem from four experimental systems all of which do not repair DNA: the translation of E.
Ponta, H. +4 more
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RNA decay by messenger RNA interferases.
Methods in enzymology, 2008Two abundant toxin-antitoxin (TA) gene families, relBE and mazEF, encode mRNA cleaving enzymes whose ectopic overexpression abruptly inhibits translation and thereby induces a bacteriostatic condition. Here we describe and discuss protocols for the overproduction, purification, and analysis of mRNA cleaving enzymes such as RelE of Escherichia coli and ...
Christensen-Dalsgaard M +3 more
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The relation of messenger to nucleolar RNA
Experimental Cell Research, 1962Abstract 1. 1. Nucleolar RNA has a vectorial turnover with the dense-particulate part at the origin determining either a centrifugal or a centripetal stable pattern. 2. 2. The centrifugal turnover pattern used in this work lends itself to inhibition studies. 3. 3.
J L, SIRLIN, J, JACOB, K I, KATO
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The structure of pre-messenger RNA and messenger RNA from erythroid cells
1977Pre-mRNA fractions (greater than 45 S) were characterized by electron microscopy. High salt concentrations (0.2 M ammonium acetate, pH 8) yield linear molecules of different length (0.5--17 micrometer). In 10% of the molecules a compact-nonlinear contour (cn-contour) is detectable at one end.
A M, Ladhoff +3 more
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Hormone inducible messenger RNA
Life Sciences, 1975Abstract Steroid hormones regulate the synthesis of specific proteins in target tissue by controlling the synthesis of the corresponding messenger RNA's. In the chick oviduct, estrogen and progesterone induce the synthesis and accumulation of the specific messenger RNA's for the hormone-induced egg-white proteins, ovalbumin and avidin, respectively ...
S L, Woo, B W, O'Malley
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Virology, 1974
Abstract Influenza viral messenger RNA (mRNA) free from both ribosomal RNA and newly synthesized host mRNA was isolated from the polyribosomes of infected canine kidney cells. Cordycepin was added to infected cells to inhibit ribosomal RNA and host mRNA synthesis.
P R, Etkind, R M, Krug
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Abstract Influenza viral messenger RNA (mRNA) free from both ribosomal RNA and newly synthesized host mRNA was isolated from the polyribosomes of infected canine kidney cells. Cordycepin was added to infected cells to inhibit ribosomal RNA and host mRNA synthesis.
P R, Etkind, R M, Krug
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