Results 201 to 210 of about 1,216,475 (294)

Overexpression of TCF7L2 promotes the viability and migration of MHCC-97H human hepatocellular carcinoma cells by upregulating MT-ND4L. [PDF]

Transl Cancer Res
Chen R, Liu W, Yang Z, Hao W, Chen B, Zhao S, Zheng L, Lu J.   +7 more
europepmc   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Obesity-related palmitic acid exacerbates IL-13-induced mucus phenotype in 16HBE airway epithelial cells via AMPK suppression. [PDF]

Transl Pediatr
Liu Q, Chang X, Jing W, Liu S.
europepmc   +1 more source

Acute effects of anti‐seizure medications on network level dynamics: A systematic comparison using multielectrode arrays

Epilepsia, EarlyView.
Abstract Objective A multi‐electrode array (MEA) is a powerful extracellular recording technique for long‐term monitoring of neuronal network activity. In recent years, MEA‐based assays have been applied increasingly to evaluate drug efficacy and neurotoxicity, including the assessment of anti‐seizure medications (ASMs). However, systematic comparisons
Griselda Marku, Lena Gschossmann, Kerstin Hallmann, Heinz Beck, Kunihiko Araki   +4 more
wiley   +1 more source

Identification of a Circular RNA as a Potential Diagnostic and Prognostic Biomarker in Breast Cancer Through Integrated Bioinformatic and Experimental Analyses. [PDF]

Anal Sci Adv
Hashemi M, Morovat P, Khoshghiafeh A, Nikbakhsh N, Ahmadifard M.   +4 more
europepmc   +1 more source

Phenotypic and transcriptomic characterization of biallelic RNU2‐2 developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Abstract Objective A significant proportion of individuals with suspected genetic developmental and epileptic encephalopathies (DEEs) remain unsolved following whole genome sequencing (WGS). Here we describe biallelic RNU2‐2 variants causing a recently reported, severe, recessive DEE.
Olivia J. Henry, Nadja Pekkola Pacheco, Irene Duba, Magnus Burstedt, Daniel Carlberg, Angelica M. Delgado‐Vega, Anna Hammarsjö, Sofie Ivarsson, Tord Jonson, Kristina Karrman, Nicole Lesko, Åsa Lindfors, Daniel Nilsson, Mia Olsson Engman, Lucía Peña‐Pérez, Erik Stenund, Fulya Taylan, Malin Ueberschär, Samuel Wiafe, Sofia Ygberg, Anna Lindstrand, Anna Wedell, Ann Nordgren, Tommy Stödberg   +23 more
wiley   +1 more source

Endolysosomal routing combined with immune stimulation enhances anti-tumor efficacy of an HPV16 mRNA therapeutic vaccine. [PDF]

Mater Today Bio
Song W, Ying B, Gao P, Zhang Z, Ma X, Ma J, Yang S, Wu Y, Wu D, Wu J, Du T.   +10 more
europepmc   +1 more source

Transcriptomic analysis reveals distinct expression patterns in focal cortical dysplasia

Epilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) is a common cause of drug‐resistant epilepsy in children and adults and exhibits substantial clinical and histopathological heterogeneity. However, morphological classification alone does not fully explain variability in epileptogenicity, disease severity, or treatment response.
Shivani Sonawane, Michal Hendrych, Michaela Ručková, Robin Jugas, Jan Vrbský, Martin Pail, Barbora Straka, Martina Strnadová, Lenka Krsková, Adam Vácha, Miroslav Koblížek, Barbora Splítková, Kateřina Koželková, Eliška Hloušková, Tereza Vaňková, Josef Zámečník, Štefánia Aulická, Markéta Hermanová, Pavel Kršek, Ondřej Slabý, Milan Brázdil   +20 more
wiley   +1 more source

<i>SAE1</i> knockdown attenuates hepatic fibrosis by promoting ubiquitination and proteasomal degradation of TGF-β receptors. [PDF]

BMJ Open Gastroenterol
Liu T, Wang M, Zheng G, Wu Y, Shen J, Dong X, Sun Q, Zhang Y, Tian W.   +8 more
europepmc   +1 more source