Results 201 to 210 of about 180,763 (256)

Immunomodulatory Effect of Tilapia (Oreochromis niloticus) Scale Gelatin Peptides in RAW264.7 Macrophages and Caenorhabditis elegans

Food Safety and Health, EarlyView.
ABSTRACT Currently, small‐molecular‐weight collagen peptides are a research hotspot in functional factor development due to their high bioavailability and diverse bioactivities. In this study, gelatin was extracted from tilapia (Oreochromis niloticus) scales by hot water extraction, followed by pepsin hydrolysis and ultrafiltration to obtain the < 3 ...
Ya‐ru Liu, Xu Guo, Shu‐tao Sun, Rui‐rui Zhang, Chao Liu, Ning‐yang Li   +5 more
wiley   +1 more source

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Messenger RNA-based vaccines

Expert Opinion on Biological Therapy, 2004
RNA is the only molecule known to recapitulate all biochemical functions of life: definition, control and transmission of genetic information, creation of defined three-dimensional structures, enzymatic activities and storage of energy. Because of its versatility and thanks to several recent scientific breakthroughs, RNA became the focus of intense ...
Steve Pascolo
exaly   +3 more sources

Messenger RNA Decay

EcoSal Plus, 2007
This chapter discusses several topics relating to the mechanisms of mRNA decay. These topics include the following: important physical properties of mRNA molecules that can alter their stability; methods for determining mRNA half-lives; the genetics and biochemistry of proteins and enzymes involved in mRNA decay; posttranscriptional ...
openaire   +2 more sources

Messenger RNA movement on the ribosome

Molecular Biology, 2007
Recent X-ray and cryo-EM studies of 70S ribosome complexes containing different types of messenger RNAs (mRNA) and transfer RNA (tRNA) have been reviewed. Changes of the mRNA path on the ribosome at initiation and elongation states have been described.
Yusupova, G., Jenner, L., Yusupov, M.
openaire   +3 more sources

A CRISPR cut for messenger RNAs

Lab Animal, 2020
To achieve knockdown rather than knockout of particular genes, a new paper demonstrates a CRISPR/Cas13 method that can efficiently edit mRNA in zebrafish, medaka, killifish, and mouse embryos.
Rebecca, Leech, Karuna, Sampath
openaire   +2 more sources

Evidence that immune RNA is messenger RNA

Cellular Immunology, 1976
Abstract Exposure of rabbit spleen cell cultures to i-RNA isolated from T2 phage-exposed rabbit peritoneal exudate cells induces the synthesis of antigen and allotype specific 19S proteins even in the presence of actinomycin D. The same i-RNA directs the synthesis of proteins with comparable properties in cell-free extracts prepared from mouse L ...
P, Bilello, M, Fishman, G, Koch
openaire   +2 more sources

Vaccination With Messenger RNA

2006
As an alternative to DNA-based vaccines, messenger RNA (mRNA)-based vaccines present additional safety features: no persistence, no integration in the genome, no induction of autoantibodies. Moreover, mRNA which are generated by in vitro transcription, are easy to produce in large amounts and very high purity.
openaire   +2 more sources

Messenger Properties of TYMV-RNA

Virology, 1977
Abstract Turnip yellow mosaic virus (TYMV) RNA extracted from virions (“virion” TYMV-RNA) contains two types of molecules of molecular weight 2 × 10 6 : one which resists heat denaturation (“intact” TYMV-RNA) and one which yields smaller fragments upon heat denaturation (TYMV-RNA containing hidden breaks).
B, Ricard, C, Barreau, H, Renaudin, C, Mouches, J M, Bové   +4 more
openaire   +2 more sources

Messenger RNA Modifications in Plants

Trends in Plant Science, 2019
Over 160 distinct RNA modifications are known and collectively termed the epitranscriptome. Some of these modifications have been discovered in mRNA, uncovering a new layer of gene regulation. Transcriptome-wide mapping of epitranscriptomic codes and the discovery of their writers, erasers, and readers that dynamically install, remove, and interpret ...
Lisha, Shen, Zhe, Liang, Chui Eng, Wong, Hao, Yu   +3 more
openaire   +2 more sources

Intranuclear Trafficking of Messenger RNA

Critical Reviews™ in Eukaryotic Gene Expression, 1999
Within the nucleus, protein-encoding genes are transcribed into messenger RNA by RNA polymerase II. Messenger RNAs migrate to the cytoplasm, but before reaching their final destination the primary transcripts must undergo a series of modifications that include 5'-capping, splicing, and 3'-cleavage/polyadenylation.
M, Carmo-Fonseca, N, Custódio, A, Calado   +2 more
openaire   +2 more sources