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Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery
Nano letters (Print), 2020Lipid nanoparticle (LNP) packaged mRNA vaccines have been deployed against infectious diseases such as COVID-19, yet their structural features remain unclear.
Yulia Eygeris+3 more
semanticscholar +1 more source
Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction.
Science, 1992Effective methods are needed to identify and isolate those genes that are differentially expressed in various cells or under altered conditions. This report describes a method to separate and clone individual messenger RNAs (mRNAs) by means of the ...
Peng Liang, A. Pardee
semanticscholar +1 more source
Messenger RNA Modifications in Plants.
Trends in Plant Science, 2019Over 160 distinct RNA modifications are known and collectively termed the epitranscriptome. Some of these modifications have been discovered in mRNA, uncovering a new layer of gene regulation. Transcriptome-wide mapping of epitranscriptomic codes and the discovery of their writers, erasers, and readers that dynamically install, remove, and interpret ...
Lisha Shen, Zhe Liang, C. Wong, Hao Yu
semanticscholar +4 more sources
How Is Precursor Messenger RNA Spliced by the Spliceosome?
Annual Review of Biochemistry, 2019Splicing of the precursor messenger RNA, involving intron removal and exon ligation, is mediated by the spliceosome. Together with biochemical and genetic investigations of the past four decades, structural studies of the intact spliceosome at atomic ...
R. Wan, R. Bai, X. Zhan, Yigong Shi
semanticscholar +1 more source
Messenger RNA movement on the ribosome
Molecular Biology, 2007Recent X-ray and cryo-EM studies of 70S ribosome complexes containing different types of messenger RNAs (mRNA) and transfer RNA (tRNA) have been reviewed. Changes of the mRNA path on the ribosome at initiation and elongation states have been described.
Yusupova, G., Jenner, L., Yusupov, M.
openaire +4 more sources