Results 41 to 50 of about 418,972 (212)
Rapid nuclear deadenylation of mammalian messenger RNA
iScience, 2023 Summary: Poly(A) tails protect RNAs from degradation and their deadenylation rates determine RNA stability. Although poly(A) tails are generated in the nucleus, deadenylation of tails has mostly been investigated within the cytoplasm.
Jonathan Alles +3 more
doaj
RNA-sequencing analysis reveals the long noncoding RNA profile in the mouse myopic retina
Frontiers in Genetics, 2022 Aim: Myopia is a prevalent public health problem. The long noncoding RNA (lncRNA) mechanisms for dysregulated retinal signaling in the myopic eye have remained elusive.
Yuanjun Li +29 more
doaj +1 more source
Interacting RNA polymerase motors on DNA track: effects of traffic congestion and intrinsic noise on RNA synthesis [PDF]
Physical Review E 77, 011921 (2008), 2007 RNA polymerase (RNAP) is an enzyme that synthesizes a messenger RNA (mRNA) strand which is complementary to a single-stranded DNA template. From the perspective of physicists, an RNAP is a molecular motor that utilizes chemical energy input to move along the track formed by a DNA. In many circumstances, which are described in this paper, a large number
arxiv +1 more source
The messenger: the structure of RNA [PDF]
Biochemical Journal, 2006 In the early part of the 20th Century, the nature of nucleic acid and what its role was within the cell were a bit of a mystery. DNA itself was first isolated as far back as 1869 by the Swiss chemist Johann Friedrich Miescher. He separated nuclei from the cytoplasm of cells and then isolated an acidic substance from these nuclei that he called nuclein1.
openaire +2 more sources
The isolation of plasmids containing DNA complementary to messenger RNA for variant surface glycoproteins of Trypanosoma brucei. [PDF]
, 1980 We have isolated poly(A)+ RNA from four antigenic variants (117, 118, 121, 221) of one clone of Trypanosoma brucei. Translation of these poly(A)+ RNAs in a rabbit reticulocyte lysate gave rise to proteins that could be precipitated with antisera against ...
Borst, P. (Piet) +4 more
core +2 more sources
Splicing of Messenger RNA Precursors
Cold Spring Harbor Symposia on Quantitative Biology, 1987 A general mechanism for the splicing of nuclear messenger RNA precursors in eukaryotic cells has been widely accepted. This mechanism, which generates lariat RNAs possessing a branch site, seems related to the RNA-catalyzed reactions of self-splicing introns.
Sharp, P. A. +5 more
openaire +8 more sources
Systematic transcriptome wide analysis of lncRNA-miRNA interactions [PDF]
, 2012 Long noncoding RNAs (lncRNAs) are a recently discovered class of non-protein coding RNAs which have now increasingly been shown to be involved in a wide variety of biological processes as regulatory molecules. Little is known regarding the regulatory interactions between noncoding RNA classes.
arxiv +1 more source
Deep learning models for predicting RNA degradation via dual crowdsourcing [PDF]
arXiv, 2021 Messenger RNA-based medicines hold immense potential, as evidenced by their rapid deployment as COVID-19 vaccines. However, worldwide distribution of mRNA molecules has been limited by their thermostability, which is fundamentally limited by the intrinsic instability of RNA molecules to a chemical degradation reaction called in-line hydrolysis ...
arxiv
A thermostable messenger RNA based vaccine against rabies. [PDF]
PLoS Neglected Tropical Diseases, 2017 Although effective rabies virus vaccines have been existing for decades, each year, rabies virus infections still cause around 50.000 fatalities worldwide. Most of these cases occur in developing countries, where these vaccines are not available.
Lothar Stitz +8 more
doaj +1 more source
The Spanning Tree Model and the Assembly Kinetics of RNA Viruses [PDF]
arXiv, 2021 Single-stranded (ss) RNA viruses self-assemble spontaneously in solutions that contain the viral RNA genome molecules and the viral capsid proteins. The self-assembly of empty capsids can be understood on the basis of free energy minimization of rather simple models.
arxiv