Results 31 to 40 of about 1,216,475 (294)

Modelling ribosome kinetics and translational control on dynamic mRNA.

PLoS Computational Biology, 2023
The control of protein synthesis and the overall levels of various proteins in the cell is critical for achieving homoeostasis. Regulation of protein levels can occur at the transcriptional level, where the total number of messenger RNAs in the overall ...
Eric C Dykeman
doaj   +1 more source

Guardian of Genetic Messenger-RNA-Binding Proteins

Biomolecules, 2016
RNA in cells is always associated with RNA-binding proteins that regulate all aspects of RNA metabolism including RNA splicing, export from the nucleus, RNA localization, mRNA turn-over as well as translation. Given their diverse functions, cells express
Antje Anji, Meena Kumari
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

RNA-sequencing analysis reveals the long noncoding RNA profile in the mouse myopic retina

Frontiers in Genetics, 2022
Aim: Myopia is a prevalent public health problem. The long noncoding RNA (lncRNA) mechanisms for dysregulated retinal signaling in the myopic eye have remained elusive.
Yuanjun Li, Yuanjun Li, Yuanjun Li, Ying Lu, Ying Lu, Ying Lu, Kaixuan Du, Kaixuan Du, Kaixuan Du, Yewei Yin, Yewei Yin, Yewei Yin, Tu Hu, Tu Hu, Tu Hu, Qiuman Fu, Qiuman Fu, Qiuman Fu, Yanni Zhang, Yanni Zhang, Yanni Zhang, Dan Wen, Dan Wen, Dan Wen, Xiaoying Wu, Xiaoying Wu, Xiaoying Wu, Xiaobo Xia, Xiaobo Xia, Xiaobo Xia   +29 more
doaj   +1 more source

BRUCE: a program for the detection of transfer-messenger RNA genes in nucleotide sequences [PDF]

, 2002
A computer program, BRUCE, was developed for the identification of transfer‐messenger RNA (tmRNA) genes. The program employs heuristic algorithms to search for a tRNAAla‐like secondary structure surrounding a short sequence encoding the tag peptide.
Andersson, S., Laslett, D., Canback, B.
core  

A cytoplasmic complex mediates specific mRNA recognition and localization in yeast [PDF]

, 2011
In eukaryotes, hundreds of mRNAs are localized by specialized transport complexes. For localization, transcripts are recognized by RNA-binding proteins and incorporated into motor-containing messenger ribonucleoprotein particles (mRNPs).
Henning Urlaub, Cramer, P., Andreas Mayer, Kramer, Katharina, Niessing, Dierk, Jansen, R., Urlaub, Henning, Heym Roland Gerhard, Heym, R. G., Schmid, M., Mueller, M., Heym, R.G., Müller, Marisa, Schmid Maria, Jansen Ralf-Peter, Cramer Patrick, Niessing, D., Roland Gerhard Heym, Kramer, K., Meyer, A., Urlaub Henning, Mayer, A., Müller Marisa, Jansen, Ralf-Peter, Jansen, R.P., Mayer Andreas, Maria Schmid, Cramer, Patrick, Schmid, Maria, Patrick Cramer, Urlaub, H., Katharina Kramer, Jansen, R.-P., Niessing Dierk, Ralf-Peter Jansen, Kramer Katharina, Müller, M., Heym, R., Mayer, Andreas, Dierk Niessing, Heym, Roland Gerhard, Marisa Müller   +41 more
core   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Eukaryotic translation initiation factors and cancer

Tumor Biology, 2017
Recent technological advancements have shown tremendous mechanistic accomplishments in our understanding of the mechanism of messenger RNA translation in eukaryotic cells.
Muhammad Umar Ali, Muhammad Saif Ur Rahman, Zhenyu Jia, Cao Jiang   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source