Results 61 to 70 of about 473,734 (283)

Changes in the expression of genes involved in cell cycle regulation and the relative telomere length in the process of canceration induced by omethoate

Tumor Biology, 2017
Organophosphorous pesticides (OPs), with high efficiency, broad-spectrum and low residue, are widely used in China. Omethoate is a broad category of organophosphorous pesticides and is more domestically utilized which has chronic toxic effect on human ...
Xiaoran Duan, Yongli Yang, Sihua Wang, Xiaolei Feng, Tuanwei Wang, Pengpeng Wang, Suxiang Liu, Lei Li, Wu Yao, Liuxin Cui, Wei Wang   +10 more
doaj   +1 more source

Optimization of the piggyBac transposon using mRNA and insulators: toward a more reliable gene delivery system. [PDF]

PLoS ONE, 2013
Integrating and expressing stably a transgene into the cellular genome remain major challenges for gene-based therapies and for bioproduction purposes.
Solenne Bire, Déborah Ley, Sophie Casteret, Nicolas Mermod, Yves Bigot, Florence Rouleux-Bonnin   +5 more
doaj   +1 more source

Heat Stress-Dependent Association of Membrane Trafficking Proteins With mRNPs Is Selective

Frontiers in Plant Science, 2021
The Arabidopsis AAA ATPase SKD1 is essential for ESCRT-dependent endosomal sorting by mediating the disassembly of the ESCRTIII complex in an ATP-dependent manner.
Heike Wolff, Marc Jakoby, Lisa Stephan, Eva Koebke, Martin Hülskamp   +4 more
doaj   +1 more source

ELAV mediates 3' UTR extension in the Drosophila nervous system

, 2012
Post-transcriptional gene regulation is prevalent in the nervous system, where multiple tiers of regulatory complexity contributeto the development and function of highly specialized cell types.
Hilgers, V., Lemke, S., Levine, M.
core   +1 more source

Localisation of RNAs into the germ plasm of vitellogenic xenopus oocytes [PDF]

, 2013
We have studied the localisation of mRNAs in full-grown Xenopus laevis oocytes by injecting fluorescent RNAs, followed by confocal microscopy of the oocyte cortex.
B Heinrich, C Hudson, C Wang, CM Gallo, CP Brangwynne, DR Drummond, F Bontems, F Lai, FF Lai, FL Marlow, Gert Jan C. Veenstra, H MacArthur, H MacArthur, Hugh R. Woodland, HW Song, IM Palacios, J Heasman, J Heasman, JA Gagnon, JB Glotzer, JK Yisraeli, JK Yisraeli, JN Betley, JO Deshler, K Kosaka, K Yaniv, KE Schroeder, KM Forrest, L Allen, L Dale, L Mosquera, M Claussen, M Claussen, M Kloc, M Kloc, M Kloc, M Kloc, M Kloc, M Kloc, M Ku, ME Kloc, ME Pepling, ML King, NR Zearfoss, O Hachet, P Chang, PM Macdonald, PT Richardson, QH Tao, RA Lewis, RJ Machado, RS Hames, RT Cox, S Choo, S Guedes, S Kwon, Sarbjit Nijjar, SN Hird, TJ Messitt, U Wolke, VB Alarcon, VL Zimyanin, WV Gerber, Y Zhang, Y Zhou, Y Zhou, Y Zhou   +66 more
core   +2 more sources

Engineering Hybrid Extracellular Vesicles for Functional mRNA Delivery

Advanced Functional Materials, EarlyView.
This study optimizes two methods for the generation of extracellular vesicle (EV)‐mimetic‐Lipid Nanoparticle (LNP) (CELLNPs) and EV‐LNP (HEVs) hybrid nanoparticles for messenger (mRNA) delivery. The authors screen lipid compositions to maximize hybrid nanoparticle formation and analyze the resulting nanoparticles with single particle characterization ...
Ana Filipa Louro, Inês Gomes, Chuan‐En Lu, Marco A. Alfonzo‐Méndez, Niek Dekker, Mohsin Khan, Elisa Lázaro‐Ibáñez   +6 more
wiley   +1 more source

Long-Distance Transport of Prosystemin Messenger RNA in Tomato

Frontiers in Plant Science, 2017
Main conclusion: The transcripts of transgenic prosystemin (PS) gene are mobile and the PS mRNA can be translated into protein in tomato and tobacco plants.
Haiyan Zhang, Yuanyuan Hu, Yuanyuan Hu
doaj   +1 more source

CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome. [PDF]

, 2019
Multiple genome-wide studies have identified associations between outcome of human immunodeficiency virus (HIV) infection and polymorphisms in and around the gene encoding the HIV co-receptor CCR5, but the functional basis for the strongest of these ...
Anderson, Stephen K, Carrington, Mary, Chowdhury, Fatema Z, Deeks, Steven G, Ewy, Rodger, Gatanaga, Hiroyuki, Goedert, James J, Haas, David W, Hoots, W Keith, Kirk, Gregory D, Kulkarni, Smita, Kulkarni, Viraj, Le Gall, Sylvie, Lied, Alexandra, Lin, Zhansong, Margolick, Joseph, Martin, Maureen P, McLaren, Paul J, Michael, Nelson, Naranbhai, Vivek, Nguyen, Hoang, Oka, Shinichi, Rucevic, Marijana, Singh, Sukhvinder, Takiguchi, Masafumi, Thio, Chloe L, Viard, Mathias, Walker, Bruce, Walker-Sperling, Victoria, Yu, Xu G, Zou, Chengcheng   +30 more
core  

The Identification of Collagen Messenger RNA [PDF]

Proceedings of the National Academy of Sciences, 1974
RNA isolated from calvaria of 16- to 18- day-old chick embryos, assayed in rabbit reticulocyte lysates, programs the synthesis of a collagenase-sensitive protein with the molecular weight of collagen pro-α-chains. When RNA labeled with [ 3 H]uridine for 2 hr and chased for 1 or 2 hr was electrophoresed on aqueous ...
H, Boedtker, R B, Crkvenjakov, J A, Last, P, Doty   +3 more
openaire   +2 more sources

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source