Results 131 to 140 of about 126,755 (277)

Clinofibrate Disrupts the SNORA80B/YTHDC1‐Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC

Advanced Science, EarlyView.
This study uncovers a non‐canonical role of SNORA80B in ESCC, showing it mediates AR‐driven metabolic reprogramming via N⁶‐methyladenosine (m6A) methylation. By binding YTHDC1, SNORA80B stabilizes cholesterol‐metabolic enzyme mRNAs and promotes tumor progression. The FDA‐approved drug clinofibrate inhibits SNORA80B by disrupting cholesterol homeostasis,
Hongyu Yuan, Ge Ge, LiQiu Liu, Sijun Hu, Miaomiao Tian, Yongzhan Nie, Zitong Zhao, Yongmei Song   +7 more
wiley   +1 more source

Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles

Advanced Science, EarlyView.
This study presents heparin‐derived nanoparticles (HP‐NPs) as a novel precision medicine platform that combines therapeutic and delivery functions. HP‐NPs target drug‐resistant glioblastoma stem cells, reprogramming them into a drug‐sensitive phenotype and significantly reducing tumor progression.
Vadim Le Joncour, Austin D. Evans, Camilla Karoliina Bergström, Vignesh Kumar Rangasami, Sumanta Samanta, Nithiyanandan Krishnan, Yuji Teramura, Bo Nilsson, Patricia Hedenqvist, Elin Manell, Jons Hilborn, Marianne‐Jensen Waern, Oommen P. Varghese, Pirjo Laakkonen, Oommen P. Oommen   +14 more
wiley   +1 more source

The complete sequence of the mitochondrial genome of the Chinook salmon, Oncorhynchus tshawytscha

Biological Research, 2003
The complete sequence of the mitochondrial genome of Chinook salmon, Oncorhynchus tshawytscha, has been determined. The circular genome consisting of 16,644 base pairs encodes thirteen proteins, the 12S and 16S ribosomal RNAs, and 22 transfer RNAs. These
VIVIAN WILHELM, JAIME VILLEGAS, ÁLVARO MIQUEL, ESTEBAN ENGEL, SEBASTIÁN BERNALES, PABLO D.T. VALENZUELA, LUIS O. BURZIO   +6 more
doaj  

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Chemotactic responses to gas oil of Halomonas spp. strains isolated from saline environments in Argentina Respuesta quimiotáctica hacia gas oil de cepas de Halomonas spp. aisladas de ambientes salinos de Argentina

Revista Argentina de Microbiología, 2011
In this study, two halophilic bacterial strains isolated from saline habitats in Argentina grew in the presence of gas oil. They were identified as Halomonas spp. and Nesterenkonia sp. by 16S ribosomal RNA sequencing.
Sebastián D´Ippólito, Rosana E. de Castro, Karina Herrera Seitz   +2 more
doaj  

RiboMicrobe: An Integrated Translatome Atlas for Microorganism

Advanced Science, EarlyView.
RiboMicrobe is a comprehensive database for Ribo‐seq data from prokaryotes, featuring 891 Ribo‐seq, 369 RNA‐seq, and 62 proteome datasets from 38 species. The database not only provides various data visualization results but also includes two sORF prediction models and a suit of bioinformatics tools for comparative analysis, facilitating easy access ...
Yingshun Zhou, Jinjing Luo, Xiaoqiang Lang, Yuli Gan, Guoxian Liu, Yuling Cui, Fazhi Li, Weicong Zhu, Bing Chen, Yuanyuan Dong, Yinglin Wu, Yi Cao, Qi Liu   +12 more
wiley   +1 more source

EFFECTIVENESS OF BACILLUS THURINGIENSIS AS A BIOCONTROL AGENT AGAINST ROOT-KNOT NEMATODES ON TOMATO PLANT

The Iraqi Journal of Agricultural science
This study aimed to evaluate the nematicidal effect of three local Bacillus thuringiensis isolates in controlling the root-knot nematodes Meloidogyne spp. under laboratory and shade house conditions.
Saad T. A. Yass, Khalid M. Al-Juhaishi, Sarah Tareq Hasan, Deepak K. Sinha   +3 more
doaj   +1 more source

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

Advanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha, Kyle L. MacQuarrie, Marcelo Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert Nap, Parambir S. Dulai, Igal Szleifer, Vadim Backman   +11 more
wiley   +1 more source

Integrative pan-cancer analysis of intratumoral microbial communities for biomarker discovery and diagnostic modeling

Journal of Translational Medicine
Background While large-scale pan-cancer studies have extensively characterized host genomic and molecular features, systematic analyses of microbial signatures across diverse cancer types remain scarce. This study aims to address this gap by employing 16 
Liuliu Quan, Huiteng Rong, Jian Yue, Jing Xu, Yujie Zheng, Peng Yuan   +5 more
doaj   +1 more source

Engineering Dimensional Configuration of Single‐Atom S‐Cu‐S Sites as Reversible Electron Station for Enhanced Peroxidase‐Mimicking

Advanced Science, EarlyView.
L‐cysteine triggers auto‐assembly of POD‐like 3D biomimetic S‐Cu‐S single‐atom nanozymes on MoS2 (MoCC). MoCC shows 16.3‐fold higher catalytic velocity and 17.9‐fold greater affinity than HRP, enabling efficient •OH generation via enhanced electron inversion and transfer.
Wenjie Ma, Qian He, Jiancheng Sun, Yiqing Chen, Hongfei Su, Ludan Zhang, Xiao He, Yuguang Wang, Changjian Xie, Zhiyong Zhang, Xin Zhou, Yuliang Zhao, Wenyan Yin   +12 more
wiley   +1 more source