Results 81 to 90 of about 46,527 (308)

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability [PDF]

, 2009
Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase important for c-Myc–induced proliferation in skin, but the mechanisms by which Misu contributes to cell cycle progression are unknown.
Michaela Frye, Benavente, Sandra Blanco, Elisabete Nascimento, Kurowski, Agata, Nascimento, Elisabete, Hussain, Shobbir, Ilaria Dragoni, Dragoni, Ilaria, Gillich, Astrid, Shobbir Hussain, Sandra Blanco Benavente, Astrid Gillich, Frye, Michaela, Peter Humphreys, Humphreys, Peter, Agata Kurowski   +15 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Cytauxzoon felis and 'Candidatus Mycoplasma haemominutum' coinfection in a Brazilian domestic cat (Felis catus)

Revista Brasileira de Parasitologia Veterinária
This article describes the first detection of Cytauxzoon felis, using molecular techniques, in a naturally infected domestic cat from Brazil, South America. Coinfection with 'CandidatusMycoplasma haemominutum' was also found. The molecular identification
Leticia Mendes Pupio Maia, Aloysio de Mello Figueiredo Cerqueira, Daniel de Barros Macieira, Aline Moreira de Souza, Namir Santos Moreira, Adrianna Vieira da Silva, Joanne Belle Messick, Renata Fernandes Ferreira, Nádia Regina Pereira Almosny   +8 more
doaj   +1 more source

The longest 18S ribosomal RNA ever known [PDF]

European Journal of Biochemistry, 1991
An EMBL4 recombinant phage which encodes one of the full length of the aphid ribosomal DNA has been isolated from the aphid genomic library. Determination of the complete nucleotide sequence of the aphid 18S rRNA gene revealed that it is 2469 bp with a G + C content of 59%.
O Y, Kwon, K, Ogino, H, Ishikawa
openaire   +2 more sources

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

18S ribosomal RNA methyltransferase METTL5-mediated CDX2 translation regulates porcine early embryo development

Journal of Integrative Agriculture
N6-methyladenosine (m6A) plays a key role in mammalian early embryonic development and cell lineage differentiation. However, the role and mechanisms of 18S ribosomal RNA (rRNA) m6A methyltransferase METTL5 in early embryonic development remain unclear ...
Tengteng Xu, Mengya Zhang, Qiuchen Liu, Xin Wang, Pengfei Luo, Tong Liu, Yelian Yan, Naru Zhou, Yangyang Ma, Tong Yu, Yunsheng Li, Zubing Cao, Yunhai Zhang   +12 more
doaj   +1 more source

Sequence determination of the 3' terminal T1 oligonucleotide of 18S ribosomal RNA

Nucleic Acids Research, 1976
We have reexamined the primary structure of the 3' terminal oligonucleotide of 18S RNA from chicken fibroblasts and have shown, contrary to previously published results that this extremity G-A-U-C-A-U-U-AOH is identical to that of the rabbit, drosophila and bombyx.
M E, Eladari, F, Galibert
openaire   +3 more sources

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Rlp7p is associated with 60S preribosomes, restricted to the granular component of the nucleolus, and required for pre-rRNA processing [PDF]

, 2002
Many analyses have examined subnucleolar structures in eukaryotic cells, but the relationship between morphological structures, pre-rRNA processing, and ribosomal particle assembly has remained unclear.
Tollervey, D, Hurt, E, Pierre-Emmanuel Gleizes, Elisabeth Petfalski, Ed Hurt, Olivier Gadal, David Tollervey, Gleizes, P E, Strauss, D, Gas, N, Daniela Strauss, Gadal, O, Petfalski, E, Nicole Gas   +13 more
core   +1 more source