Results 81 to 90 of about 93,732 (342)

Structural study of ribosomal 23 S RNA from Escherichia coli

FEBS Letters, 1979
Here we report the sequence of 80% of the ribosoma123 S RNA of Escherichia coli and describe the cistron heterogeneities and base modifications detected in this sequence. RNA sequencing techniques have been tremendously improved recently [l-3]. Nevertheless, even with these new tools, it is extremely difficult to determine the complete nucleotide ...
Branlant, C., Krol, A., Machatt, M.A., Ebel, J.P.   +3 more
openaire   +2 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Dormant non-culturable Mycobacterium tuberculosis retains stable low-abundant mRNA [PDF]

, 2015
BACKGROUND: Dormant Mycobacterium tuberculosis bacilli are believed to play an important role in latent tuberculosis infection. Previously, we have demonstrated that cultivation of M.
Azhikina, Tatyana L., Fursov, Mikhail V., Ignatov, Dmitriy V., Kaprelyants, Arseny S., Salina, Elena G., Skvortsov, Timofey A.   +5 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Characterization of 23S rRNA domain V mutations in gastric biopsy patients from the eastern Amazon

Memorias do Instituto Oswaldo Cruz, 2010
Resistance of Helicobacter pylori to clarithromycin is characterised by simple point mutations in the 23S ribosomal RNA (rRNA) gene and is responsible for the majority of cases of failure to eradicate this bacterium.
Katarine Antonia dos Santos Barile, Artur Luiz da Costa da Silva, José Nazareno Xavier, Mônica Baraúna Assumpção, Tereza Cristina de Oliveira Corvelo   +4 more
doaj   +1 more source

Codon usage studies and epitope-based peptide vaccine prediction against Tropheryma whipplei

Journal of Genetic Engineering and Biotechnology, 2022
Background The Tropheryma whipplei causes acute gastroenteritis to neuronal damages in Homo sapiens. Genomics and codon adaptation studies would be helpful advancements of disease evolution prediction, prevention, and treatment of disease.
Amit Joshi, Sunil Krishnan, Vikas Kaushik   +2 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Selection of heptapeptides that bind helix 69 of bacterial 23S ribosomal RNA [PDF]

Bioorganic & Medicinal Chemistry, 2013
Helix 69 of Escherichia coli 23S rRNA has important roles in specific steps of translation, such as subunit association, translocation, and ribosome recycling. An M13 phage library was used to identify peptide ligands with affinity for helix 69. One selected sequence, NQVANHQ, was shown through a bead assay to interact with helix 69.
Moninderpal, Kaur, Chamila N, Rupasinghe, Edvin, Klosi, Mark R, Spaller, Christine S, Chow   +4 more
openaire   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Roles of transcription factors, RBPA and SIGF, in the mycobacterium tuberculosis [PDF]

, 2016
The mechanism of prokaryotic transcription has been characterized primarily in the classic system, Escherichia coli, and cannot be confidently extended to include other prokaryotic species, such as those of the Actinobacteria phylum.
Pope, Steven Scott
core   +1 more source