Results 71 to 80 of about 93,732 (342)

Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD. [PDF]

PLoS ONE, 2017
RlmCD has recently been identified as the S-adenosyl methionine (SAM)-dependent methyltransferase responsible for the formation of m5U at U747 and U1939 of 23S ribosomal RNA in Streptococcus pneumoniae.
Yiyang Jiang, Fudong Li, Jihui Wu, Yunyu Shi, Qingguo Gong   +4 more
doaj   +1 more source

Representation, searching and discovery of patterns of bases in complex RNA structures [PDF]

We describe a graph theoretic method designed to perform efficient searches for substructural patterns in nucleic acid structural coordinate databases using a simplified vectorial representation.
Artymiuk, P.J., Harrison, A-M., South, D.R., Willett, P.   +3 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Cytosolic CTP Production Limits the Establishment of Photosynthesis in Arabidopsis

Frontiers in Plant Science, 2021
CTP synthases (CTPS) comprise a protein family of the five members CTPS1-CTPS5 in Arabidopsis, all located in the cytosol. Specifically, downregulation of CTPS2 by amiRNA technology results in plants with defects in chlorophyll accumulation and ...
Leo Bellin, Vanessa Scherer, Eva Dörfer, Anne Lau, Alexandre Magno Vicente, Jörg Meurer, Daniel Hickl, Torsten Möhlmann   +7 more
doaj   +1 more source

Identification of the prebiotic translation apparatus within the contemporary ribosome [PDF]

, 2009
A structural element that could have existed independently in the prebiotic era was identified at the active site of the contemporary ribosome. It is suggested to have functioned as a proto-ribosome catalyzing peptide bond formation and non-coded ...
Ada Yonath, Anat Bashan, Chen Davidovich, Ilana Agmon   +3 more
core   +1 more source

Influence of a 23S ribosomal RNA mutation in Helicobacter pylori strains on the in vitro synergistic effect of clarithromycin and amoxicillin

BMC Research Notes, 2012
BackgroundClarithromycin (CLR) is the most commonly recommended antibiotic in Helicobacter pylori eradication regimens, but the prevalence of CLR-resistant H. pylori is increasing. CLR resistance is associated with mutations in the 23S rRNA gene. However,
T. Sakinc, B. Baars, N. Wüppenhorst, M. Kist, J. Huebner, W. Opferkuch   +5 more
semanticscholar   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Mutations of domain V in 23S ribosomal RNA of macrolide-resistant Mycoplasma gallisepticum isolates in Egypt

Journal of Infection in Developing Countries, 2016
Introduction: Avian mycoplasmas impose a significant economic burden to the poultry industry. In recent years, macrolide-resistant Mycoplasma gallisepticum have occasionally been encountered in Egypt. Methodology: This study was designed to document the
Ahmed M Ammar, Norhan K Abd El-Aziz, Ahlam A Gharib, Hanaa K Ahmed, Amira E Lameay   +4 more
doaj   +1 more source

A method for direct mass spectrometry-based identification of mono-methylated RNA nucleoside positional isomers and its application to the analysis of Leishmania ribosomal RNA.

Analytical Chemistry, 2019
RNA post-transcriptional modifications are common in all kingdoms of life, and are predominantly affiliated with methylations at various nucleobase positions.
H. Nakayama, Y. Yamauchi, Yuko Nobe, Ko Sato, N. Takahashi, M. Shalev-Benami, T. Isobe, M. Taoka   +7 more
semanticscholar   +1 more source

Extensions of the known sequences at the 3' and 5' ends of 23S ribosomal RNA from Escherichia coli, possible base pairing between these 23S RNA regions and 16S ribosomal RNA.

Nucleic Acids Research, 1976
Extensions of the known sequences at both 3' and 5' ends of 23S ribosomal RNA are presented: The 5' terminal is pG-G-U-U-A-A-G-Cp or pG-G-U... G-U-U-A-A-G-Cp, with a very short sequence between Up and Gp and the 3'terminal is G-A-A-C-C-G-A-(G)-G-C-U-U-A-A-C-C-U-UOH. These two terminal regions exhibit a high degree of complementarity.
C. Branlant, J. Widada, A. Krol, J. Ebel
semanticscholar   +4 more sources