Results 61 to 70 of about 26,439 (217)

RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation

Photochemistry and Photobiology, EarlyView.
UV radiation and other compounds generate DNA adducts that block transcription and induce cell death if not removed by the nucleotide excision repair system. In this work, we used a small‐scale pharmacological screen to discover that inhibition of the recombinase RAD51 sensitized nonreplicating quiescent keratinocytes to both UVR and other agents that ...
Saman Khan, Angitha Nair, M. Alexandra Carpenter, Michael G. Kemp   +3 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, Volume 16, Issue 7, Page 1305-1313, July 2026.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

High‐throughput Profiling of Pseudouridines in Microbiome‐derived Bacterial RNA

Current Protocols, Volume 6, Issue 7, July 2026.
Abstract Pseudouridine (Ψ) is a widespread RNA modification that influences RNA stability, structure, and translation. However, its role in bacterial mRNA, particularly within complex microbiomes, remains poorly defined. Here, we describe a bisulfite‐based sequencing workflow coupled with a scalable computational pipeline for base‐resolution ...
Shikha Sharma, Ning Duan, Akintunde Emiola   +2 more
wiley   +1 more source

From ribosomopathies to therapeutic targets: ribosomal alterations in pediatric leukemogenesis and tumorigenesis

Frontiers in Oncology
Ribosomes are central to cellular growth and proteome maintenance, and cancer cells frequently depend on increased ribosome biogenesis and altered translation to sustain proliferation, stress tolerance, and metabolic rewiring.
Michalina Horochowska, Ewa Jakubczyk, Marek Ussowicz   +2 more
doaj   +1 more source

Evolutionary dynamics of rRNA gene clusters in cichlid fish

BMC Evolutionary Biology, 2012
Background Among multigene families, ribosomal RNA (rRNA) genes are the most frequently studied and have been explored as cytogenetic markers to study the evolutionary history of karyotypes among animals and plants. In this report, we applied cytogenetic
Nakajima Rafael T, Cabral-de-Mello Diogo C, Valente Guilherme T, Venere Paulo C, Martins Cesar   +4 more
doaj   +1 more source

RNA Polymerase III Subunit Mutations in Genetic Diseases

Frontiers in Molecular Biosciences, 2021
RNA polymerase (Pol) III transcribes small untranslated RNAs such as 5S ribosomal RNA, transfer RNAs, and U6 small nuclear RNA. Because of the functions of these RNAs, Pol III transcription is best known for its essential contribution to RNA maturation ...
Elisabeth Lata, Karine Choquet, Francis Sagliocco, Bernard Brais, Geneviève Bernard, Geneviève Bernard, Geneviève Bernard, Martin Teichmann   +7 more
doaj   +1 more source

5S Ribosomal RNA genes of the newt Notophthalmus viridescens [PDF]

Nucleic Acids Research, 1981
The genes which code for the 5S ribosomal RNA in the newt, Notophthalmus viridescens have been cloned and analyzed. Two types of repeating unit were detected: a major type consisting of a 120 bp coding region with a 111 bp spacer, and a minor type composed of a coding region, a pseudogene, and a 113 bp spacer.
B K, Kay, J G, Gall
openaire   +2 more sources

Cytogenetic Analysis of Altitude‐Associated Chromosome Variations in Campeiostachys nutans From Western Sichuan Plateau Using Multicolor GISH and ND‐FISH Approaches

Ecology and Evolution, Volume 16, Issue 7, July 2026.
The genomic and chromosomal organization of C. nutans was investigated using GISH and ND‐FISH with four oligonucleotide probes. The results showed that repetitive sequence distribution exhibited genome‐specific patterns: the H genome demonstrated high structural stability with low polymorphism, while the St genome showed moderate variation, and the Y ...
Cairong Yang, Jiezhi Yang, Yi Ou, Yueju Zhou, Zhimeng Wang, Weiliang Qi, Dingfang Luo, Yutong Qiao   +7 more
wiley   +1 more source

Integrated genomic and transcriptomic approaches reveal oxidative stress adaptation mechanisms in a mesotrione‐resistant Amaranthus tuberculatus biotype

Pest Management Science, Volume 82, Issue 7, Page 6387-6398, July 2026.
Integrated GWAS and transcriptomics in a Canadian waterhemp biotype reveal mesotrione resistance is polygenic and metabolically driven. Significant SNPs and 187 herbicide‐responsive genes point to enhanced redox homeostasis, glutathione‐linked detoxification, lipid/secondary metabolism, and oxidative stress responses. Resistance arises from coordinated,
Martin Laforest, Marianne Bessette, Geneviève Gagnon, Sandra Flores‐Mejia, Brahim Soufiane, Marie‐Claire Goulet, Dominique Michaud   +6 more
wiley   +1 more source

Genomic Insights Into Antimicrobial Resistance and Virulence of Enterococcus avium Strains From Bovine Mastitis in Some Selected Dairy Farms of Bangladesh

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
The graphical abstract outlines that samples from milk, faeces and soil were tested for Enterococcus avium using culture, PCR and genome sequencing.2. Overall, prevalence of E. avium was 56.3%, and 93.5% of isolates were multidrug‐resistant.3. Genomic analysis revealed six ARGs, 43–45 VFGs and 4–6 bacteriocins.4.
Monira Rahaman, Md. Morshedur Rahman, Kh. Yeashir Arafat, Md. Abu Ahsan Gilman, Naim Siddique, Taniya Sultana, Ziban Chandra Das, Anup Kumar Talukder, Tofazzal Islam, A. N. M. Aminoor Rahman, M. Nazmul Hoque   +10 more
wiley   +1 more source