Results 121 to 130 of about 1,352,832 (329)

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development

Advanced Science, EarlyView.
Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley   +1 more source

SARS-CoV-2 targets ribosomal RNA biogenesis

Cell Reports
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hinders host gene expression, curbing defenses and licensing viral protein synthesis and virulence.
V. Talya Yerlici, Audrey Astori, Nevraj S. Kejiou, Chris A. Jordan, Negin Khosraviani, Janet N.Y. Chan, Razqallah Hakem, Brian Raught, Alexander F. Palazzo, Karim Mekhail   +9 more
doaj  

Loss of m1acp3Ψ Ribosomal RNA Modification Is a Major Feature of Cancer

Cell Reports, 2020
Summary: The ribosome is an RNA-protein complex that is essential for translation in all domains of life. The structural and catalytic core of the ribosome is its ribosomal RNA (rRNA).
Artem Babaian, Katharina Rothe, Dylan Girodat, Igor Minia, Sara Djondovic, Miha Milek, Sandra E. Spencer Miko, Hans-Joachim Wieden, Markus Landthaler, Gregg B. Morin, Dixie L. Mager   +10 more
doaj  

New copolymers as hosts of ribosomal RNA

BMC Chemistry, 2019
Functionalized copolymers were synthesized and are proposed as hosts of RNA. The copolymers are based on carboxymethyl cellulose and poly-(ethylene glycol)-OH. These copolymers were functionalized with two amino acids, either lysine or histidine, through
Magali Hernández, Gerardo Leyva, Jonathan J. Magaña, Ariel Guzmán-Vargas, Carlos Felipe, Víctor Lara, Enrique Lima   +6 more
doaj   +1 more source

Comparison of RNA-Seq by poly (A) capture, ribosomal RNA depletion, and DNA microarray for expression profiling

BMC Genomics, 2014
BackgroundRNA sequencing (RNA-Seq) is often used for transcriptome profiling as well as the identification of novel transcripts and alternative splicing events. Typically, RNA-Seq libraries are prepared from total RNA using poly(A) enrichment of the mRNA
Wei Zhao, Xiaping He, K. Hoadley, J. Parker, D. Hayes, C. Perou   +5 more
semanticscholar   +1 more source

Sperm‐Derived CircRNA‐1572 Regulates Embryogenesis and Zygotic Genome Activation by Targeting CCNB2 via Bta‐miR‐2478‐L‐2

Advanced Science, EarlyView.
Sperm‐derived circRNA‐1572 competitively binds to bta‐miR‐2478‐L‐2 through a “sponge” mechanism to regulate cyclin B2 (CCNB2) expression, thereby modulating the distribution of fibrous actin (F‐actin) in early pig embryos, ensuring proper chromosome segregation during mitosis, and facilitating normal embryo cleavage and zygotic genome activation.
Yanfang Wu, Yaochang Wei, Yuelin Li, Yiming Dou, YongQiang Yang, Hanghang Liu, Xiaoyan Wang, Zheng Wang, Jianmin Su, Yong Zhang, Yongsheng Wang   +10 more
wiley   +1 more source

In vitro Assessment of RNA Polymerase I Activity

Bio-Protocol, 2017
In eukaryotic cells transcriptional processes are carried out by three different RNA polymerases: RNA polymerase I which specifically transcribes ribosomal RNA (rRNA), RNA polymerase II which transcribes protein-coding genes to yield messenger RNAs ...
Marzia Govoni
doaj   +1 more source

Pupylation‐Based Proximity Labeling Unravels a Comprehensive Protein and Phosphoprotein Interactome of the Arabidopsis TOR Complex

Advanced Science, EarlyView.
The target of rapamycin (TOR) complex is a central plant growth regulator. Here, the protein–protein interactions underlying its various functions are mapped by pupylation‐based proximity‐labeling in Arabidopsis, using TOR complex subunits LST8‐1 and RAPTOR1, alongside TOR inhibitor FK506‐binding protein, as baits.
Shuai Zheng, Leonard Blaschek, Delphine Pottier, Luuk Robin Hoegen Dijkhof, Beyza Özmen, Peng Ken Lim, Qiao Wen Tan, Marek Mutwil, Alexander Sebastian Hauser, Staffan Persson   +9 more
wiley   +1 more source

Bud23 promotes the final disassembly of the small subunit Processome in Saccharomyces cerevisiae.

PLoS Genetics, 2020
The first metastable assembly intermediate of the eukaryotic ribosomal small subunit (SSU) is the SSU Processome, a large complex of RNA and protein factors that is thought to represent an early checkpoint in the assembly pathway.
Joshua J Black, Richa Sardana, Ezzeddine W Elmir, Arlen W Johnson   +3 more
doaj   +1 more source

Ribosomal RNA gene repeats, their stability and cellular senescence

Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2014
The ribosomal RNA gene (rDNA) repeats form a historically well-researched region in the chromosome. Their highly repetitive structure can be identified easily which has enabled studies on DNA replication, recombination, and transcription.
Takehiko Kobayashi
semanticscholar   +1 more source