Results 141 to 150 of about 1,352,832 (329)
Function of Plant DExD/H-Box RNA Helicases Associated with Ribosomal RNA Biogenesis
Frontiers in Plant Science, 2018 Ribosome biogenesis is a highly complex process that requires several cofactors, including DExD/H-box RNA helicases (RHs). RHs are a family of ATPases that rearrange the secondary structures of RNA and thus remodel ribonucleoprotein complexes. DExD/H-box
Yuelin Liu, Ryozo Imai
doaj +1 more source
RAB3B Dictates mTORC1/S6 Signaling in Chordoma and Predicts Response to mTORC1‐Targeted Therapy
Advanced Science, EarlyView.RAB3B is unveiled as a prominent oncogenic regulator in chordoma, which can block the DUSP12‐mediated dephosphorylation of p‐S6 (S235/236). The combination of RAB3B and p‐S6 indicates a good prognostic value and predicts mTORC1 inhibitors response for chordoma patients.
Jianxuan Gao +15 more
wiley +1 more source
The unknotted strands of life: knots are very rare in RNA structures [PDF]
arXiv, 2014 The ongoing effort to detect and characterize physical entanglement in biopolymers has so far established that knots are present in many globular proteins and also abound in viral DNA packaged inside bacteriophages. RNA molecules, on the other hand, have not yet been systematically screened for the occurrence of physical knots.
arxiv
High Sugar Induced RCC2 Lactylation Drives Breast Cancer Tumorigenicity Through Upregulating MAD2L1
Advanced Science, EarlyView.This study finds that KAT2A mediates the lactylation modification of the non‐histone protein RCC2 at K124, facilitating the recruitment of free SERBP1 and aiding in the formation of the initial SERBP1‐MAD2L1 complex. SERBP1 enhances the stability of MAD2L1 mRNA and promotes cellular proliferation.
Bowen Zheng +11 more
wiley +1 more source
Advanced Science, EarlyView.A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma +13 more
wiley +1 more source
Cancer Medicine, Volume 11, Issue 24, Page 5050-5065, December 2022., 2022 The aberrant expression pattern and prognostic implications of HIVEP3 in AML were explored and validated based on versatile bioinformatics tools. A LASSO model which combined HIVEP3 with ferroptosis regulators was created to predict the prognosis for AML patients.
Xiaoning Zhang +6 more
wiley +1 more source
MTCH2 Suppresses Thermogenesis by Regulating Autophagy in Adipose Tissue
Advanced Science, EarlyView.This study demonstrates that MTCH2 acts as an evolutionarily conserved regulator of energy homeostasis across Drosophila, rodents, and humans. Adipose‐specific MTCH2 ablation enhances brown/beige adipose thermogenesis through Bcl‐2‐dependent autophagy, promoting energy expenditure and counteracting obesity‐associated metabolic disorders. These findings
Xin‐Yuan Zhao +17 more
wiley +1 more source
Prognosis prediction of stage IV colorectal cancer patients by mRNA transcriptional profile
Cancer Medicine, Volume 11, Issue 24, Page 4900-4912, December 2022., 2022 This study aimed to clarify the prognostic factors for stage IV CRC patients undergoing primary cancer resection but not liver metastasis resection. WES and RNA‐Seq were used to sequence primary cancer tissues of 78 and 84 patients, respectively. Models were established to stratify the prognosis and to predict individual patient prognosis.
Bian Wu +5 more
wiley +1 more source
Advanced Science, EarlyView.RNA modification is crucial in fibrosis diseases, but the role of m1A modification remains elusive. This study reveals that ALKBH3, an m1A demethylase, drives skin fibrosis by reshaping m6A RNA modification and stabilizing COL1A1 and FN1 mRNAs through METTL3, uncovering a crosstalk between m1A and m6A methylation in pathological events.
Liying Tu +9 more
wiley +1 more source