Results 201 to 210 of about 484,088 (306)

Processing ribosomal RNA [PDF]

Genome Biology, 2002
openaire   +2 more sources

Advancing the Exploration of the Ubiquitin‐like Protein FUBI with Synthetic Chemical Tools

ChemBioChem, EarlyView.
This study unveils a novel synthetic platform by solid‐phase peptide synthesis for generating FUBI‐based chemical tools to investigate FUBIylation, a poorly understood ubiquitin‐like signaling process linked to cancer. By employing these innovative probes, we uncover novel FUBI interactors, paving the way for transformative insights into FUBI biology ...
Francesca D’Amico, Cami M. P. Talavera Ormeño, Shivanganie Poeran, Jimmy Akkermans, Rayman T. N. Tjokrodirijo, Bharath Sampadi, Peter van Veelen, Aysegul Sapmaz, Monique P. C. Mulder   +8 more
wiley   +1 more source

Sequestration of ribosome biogenesis factors in HSV-1 nuclear aggregates revealed by spatially resolved thermal profiling. [PDF]

Sci Adv
Metzger PJ, Reed TJ, Lum KK, Botello JF, Jiang L, Brangwynne CP, Troyanskaya OG, Cristea IM.   +7 more
europepmc   +1 more source

Computational De Novo Design of Group II Introns Yields Highly Active Ribozymes

ChemBioChem, EarlyView.
Group II Introns (G2Is) are large self‐splicing ribozymes with promising biotechnological applications. This study utilized RNA inverse folding to design three novel G2Is. The designed intron Arq.I2, an unexpectedly proficient ribozyme, self‐splices not only in vitro, but also in Escherichia coli cells.
Deni Szokoli, Noemi E. Nwosu, Lukas M. Glatt, Hannes Mutschler   +3 more
wiley   +1 more source

Defining the networks that connect RNase III and RNase J-mediated regulation of primary and specialized metabolism in <i>Streptomyces venezuelae</i>. [PDF]

J Bacteriol
Pepler MAD, Mulholland EL, Montague FR, Elliot MA.   +3 more
europepmc   +1 more source

Tailored Watson–Crick Pairing Partners for Xanthosine in RNA

Chemistry – A European Journal, EarlyView.
RNAs with kappa‐xanthosine (K–X) or 2‐iminocytidine‐xanthosine (2imC–X) base pairs form stable double helices that have higher melting temperatures than those of the A–U or G–U references. Access to these novel 2imC‐modified RNAs is possible through the mild, selective chemical conversion of 2‐thiocytidine RNA precursors.
Stefan Mair, Anna Rázková, Karl Brillet, Catherina Gasser, Eric Ennifar, Ronald Micura   +5 more
wiley   +1 more source

Bacterial diversity in the honey sac during bee foraging on winter-flowering flora and dominant <i>Bacillus subtilis</i> inhibits <i>Hafnia alvei</i>. [PDF]

Front Insect Sci
Wang M, Zhao W, Zhou D, Huang J.
europepmc   +1 more source

TRiC Is a Structural Component of Mammalian Sperm Axonemes

Cytoskeleton, EarlyView.
ABSTRACT The TRiC chaperonin is responsible for folding ~5%–10% of the proteome in eukaryotic cells. Our recent cryo‐electron microscopy studies of axonemes from diverse mammalian cell types led to the surprising discovery that a fully assembled TRiC chaperonin is a structural component of mammalian sperm flagella, where it is tethered to the radial ...
Alan Brown, Miguel Ricardo Leung, Tzviya Zeev‐Ben‐Mordehai, Rui Zhang   +3 more
wiley   +1 more source

Identification of cell specific biomarkers for intellectual disability via single cell RNA sequencing and transcriptomic bioinformatics approaches. [PDF]

Sci Rep
Islam KM, Rahman MH, Hossain MA, Khan M, Rahman MM, Apu PS, Hasan MI, Ansari SA, Humayoo M.   +8 more
europepmc   +1 more source

Advances in Isotope Labeling for Solution Nucleic Acid Nuclear Magnetic Resonance Spectroscopy

ChemPlusChem, EarlyView.
Recent advances in the field of nucleic acid nuclear magnetic resonance (NMR) are presented. Stable isotope labeling protocols and new approaches to segmentally label nucleic acid with NMR‐active residues are summarized. The novel methods will have a strong impact on the future of nucleic acid NMR and the characterization of structure and dynamics of ...
Stefan Hilber, Solomon Kojo Attionu, Theodore Kwaku Dayie, Christoph Kreutz   +3 more
wiley   +1 more source