Results 31 to 40 of about 169,665 (258)

Staufen Negatively Modulates MicroRNA Activity in Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2016
The double-stranded RNA-binding protein Staufen has been implicated in various posttranscriptional gene regulatory processes. Here, we demonstrate that the Caenorhabditis elegans homolog of Staufen, STAU-1, functionally interacts with microRNAs.
Zhiji Ren, Isana Veksler-Lublinsky, David Morrissey, Victor Ambros   +3 more
doaj   +1 more source

Euchromatic transposon insertions trigger production of novel Pi- and endo-siRNAs at the target sites in the drosophila germline. [PDF]

PLoS Genetics, 2014
The control of transposable element (TE) activity in germ cells provides genome integrity over generations. A distinct small RNA-mediated pathway utilizing Piwi-interacting RNAs (piRNAs) suppresses TE expression in gonads of metazoans.
Sergey Shpiz, Sergei Ryazansky, Ivan Olovnikov, Yuri Abramov, Alla Kalmykova   +4 more
doaj   +1 more source

Ornithine Decarboxylase mRNA is Stabilized in an mTORC1-dependent Manner in Ras-transformed Cells [PDF]

, 2012
Upon Ras activation, ODC (ornithine decarboxylase) is markedly induced, and numerous studies suggest that ODC expression is controlled by Ras effector pathways. ODC is therefore a potential target in the treatment and prevention of Ras-driven tumours. In
Albig, Barreau, Bhattacharyya, Carracedo, Eulalio, Feith, Feith, Foat, Garneau, Gerner, Grens, Ito, Jacinto, Jian-Ying Wang, Johannes, Kashiwagi, Katsanou, Kawai, Kawai, Kedersha, Kertesz, Lai, Lal, Lan Xiao, Liao, Lisa M. Shantz, Liu, Lorenzini, Manzella, Marderosian, Mazan-Mamczarz, Nowotarski, Origanti, Proud, Rao, Repasky, Rousseau, Sarbassov, Shannon L. Nowotarski, Shantz, Shantz, Sofia Origanti, Song, Suswam, Suzanne Sass-Kuhn, Svitkin, Theresa D. Carr, Tong, Topisirovic, Zhang, Zou, Zou   +51 more
core   +2 more sources

Development of a minigenome cassette for Lettuce necrotic yellows virus: A first step in rescuing a plant cytorhabdovirus [PDF]

, 2020
Rhabdoviruses are enveloped negative-sense RNA viruses that have numerous biotechnological applications. However, recovering plant rhabdoviruses from cDNA remains difficult due to technical difficulties such as the need for concurrent in planta ...
Drake, P, Ibrahim, AEC, Ma, J, Van Dolleweerd, CJ   +3 more
core   +1 more source

West Nile virus encodes a microRNA-like small RNA in the 3' untranslated region which up-regulates GATA4 mRNA and facilitates virus replication in mosquito cells [PDF]

Nucleic Acids Research, 2011
West Nile virus (WNV) belongs to a group of medically important single-stranded, positive-sense RNA viruses causing deadly disease outbreaks around the world. The 3' untranslated region (3'-UTR) of the flavivirus genome, in particular the terminal 3' stem-loop (3'SL) fulfils multiple functions in virus replication and virus-host interactions. Using the
Hussain, M., Torres, S., Schnettler, E., Funk, A., Grundhoff, A., Pijlman, G.P., Khromykh, A.A., Asgari, S.   +7 more
openaire   +4 more sources

Regulatory effect of 5'tRF-LysCTT on ferroptosis in mouse cardiomyocytes and its mechanism [PDF]

精准医学杂志
Objective To investigate the regulatory effect of tRNA-derived small RNA (tsRNA) on ferroptosis in mouse cardiomyocytes and its mechanism. Methods RT-qPCR was used to measure the relative expression level of 5'tRF-LysCTT in the heart, liver, spleen ...
ZHAO Yan, WANG Kai, CHENG Xueli, WANG Kun
doaj   +1 more source

Thermodynamic characterization of an engineered tetracycline-binding riboswitch [PDF]

, 2006
Riboswitches reflect a novel concept in gene regulation that is particularly suited for technological adaptation. Therefore, we characterized thermodynamically the ligand binding properties of a synthetic, tetracycline (tc)-binding RNA aptamer, which ...
Müller, Michael, Weigand, Julia E., Weichenrieder, Oliver, Süß, Beatrix   +3 more
core   +1 more source

Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch [PDF]

, 2006
Riboswitches are highly structured elements in the 50-untranslated regions (50-UTRs) of messenger RNA that control gene expression by specifically binding to small metabolite molecules. They consist of an aptamer domain responsible for ligand binding and
Noeske, Jonas, Buck, Janina, Fürtig, Boris, Nasiri, Hamid Reza, Schwalbe, Harald (Prof. Dr.), Wöhnert, Jens   +5 more
core   +1 more source

Gene expression and stress response mediated by the epigenetic regulation of a transposable element small RNA.

PLoS Genetics, 2012
The epigenetic activity of transposable elements (TEs) can influence the regulation of genes; though, this regulation is confined to the genes, promoters, and enhancers that neighbor the TE.
Andrea D McCue, Saivageethi Nuthikattu, Sarah H Reeder, R Keith Slotkin   +3 more
doaj   +1 more source

Transcriptional Riboswitches Integrate Timescales for Bacterial Gene Expression Control

Frontiers in Molecular Biosciences, 2021
Transcriptional riboswitches involve RNA aptamers that are typically found in the 5′ untranslated regions (UTRs) of bacterial mRNAs and form alternative secondary structures upon binding to cognate ligands.
Catherine E. Scull, Shiba S. Dandpat, Rosa A. Romero, Nils G. Walter   +3 more
doaj   +1 more source