Results 21 to 30 of about 434,076 (149)

Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]

, 2011
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core   +1 more source

Physicochemical analysis of rotavirus segment 11 supports a 'modified panhandle' structure and not the predicted alternative tRNA-like structure (TRLS) [PDF]

, 2013
.Rotaviruses are a major cause of acute gastroenteritis, which is often fatal in infants. The viral genome consists of 11 double-stranded RNA segments, but little is known about their cis-acting sequences and structural elements.
A Heerschap, A L’Hernault, A Wilm, AE Simon, Andrew M. Lever, AR Gruber, BI Klasens, D Chen, D Chen, D Yue, D Yue, E Madore, E Matsuo, EC Hutchinson, Emily Manktelow, EV Puglisi, H Heus, HD Cho, J Jia, JC Kenyon, Jonathan Lever, JR Gog, JT Patton, Laura E. Easton, LE Easton, M Barro, M Estes, MA Tortorici, MW Friederich, N Figueroa, P Annamalai, Peter J. Lukavsky, PJ Lukavsky, R Giegé, R Giegé, RC Olsthoorn, S Nishimura, SC Chen, SH Bernhart, Subhajit Biswas, T Nagaike, TW Dreher, TW Dreher, TW Dreher, TW Dreher, Ulrich Desselberger, W Li, Wilson Li   +47 more
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The Rabies Virus L Protein Catalyzes mRNA Capping with GDP Polyribonucleotidyltransferase Activity

Viruses, 2016
The large (L) protein of rabies virus (RABV) plays multiple enzymatic roles in viral RNA synthesis and processing. However, none of its putative enzymatic activities have been directly demonstrated in vitro.
Minako Ogino, Naoto Ito, Makoto Sugiyama, Tomoaki Ogino   +3 more
doaj   +1 more source

Complete mitochondrial genomes of the ‘intermediate form’ of Fasciola and Fasciola gigantica, and their comparison with F. hepatica

Parasites & Vectors, 2014
Background Fascioliasis is an important and neglected disease of humans and other mammals, caused by trematodes of the genus Fasciola. Fasciola hepatica and F.
Guo-Hua Liu, Robin B Gasser, Neil D Young, Hui-Qun Song, Lin Ai, Xing-Quan Zhu   +5 more
doaj   +1 more source

Assessing cell-specific effects of genetic variations using tRNA microarrays

BMC Genomics, 2019
Background By definition, effect of synonymous single-nucleotide variants (SNVs) on protein folding and function are neutral, as they alter the codon and not the encoded amino acid.
Christine Polte, Daniel Wedemeyer, Kathryn E. Oliver, Johannes Wagner, Marcel J. C. Bijvelds, John Mahoney, Hugo R. de Jonge, Eric J. Sorscher, Zoya Ignatova   +8 more
doaj   +1 more source

The effect of amino acid deprivation on the transfer of iron through Caco-2 cell monolayers [PDF]

, 2017
Funding Source Rural and Environmental Scientific and Analytical Services, the Scottish Government Acknowledgments We thank Dr Helen Hayes for her technical support during this project.
Cottin, Sarah, McArdle, Harry J., Roussel, Guenievre, Stevens, Valerie   +3 more
core   +3 more sources

The Role of tRNA-Derived Small RNAs (tsRNAs) in Regulating Cell Death of Cardiovascular Diseases

Biology
Transfer RNA is a class of non-coding RNA that plays a role in amino acid translocation during protein synthesis. After specific modification, the cleaved fragment is called tRNA-derived small RNA.
Jiaxu Guo, Xinzhe Chen, Jiahao Ren, Yunhong Wang, Kun Wang, Sumin Yang   +5 more
doaj   +1 more source

Tv-RIO1 – an atypical protein kinase from the parasitic nematode Trichostrongylus vitrinus [PDF]

, 2008
Background: Protein kinases are key enzymes that regulate a wide range of cellular processes, including cell-cycle progression, transcription, DNA replication and metabolic functions. These enzymes catalyse the transfer of phosphates to serine, threonine
Gasser, Robin B., Hu, Min, LaRonde-LeBlanc, Nicole, Sternberg, Paul W.   +3 more
core   +6 more sources

Lecithin:retinol acyltransferase from mouse and rat liver: cDNA cloning and liver-specific regulation by dietary vitamin A and retinoic acid1

Journal of Lipid Research, 2000
Lecithin:retinol acyltransferase (LRAT), present in microsomes, catalyzes the transfer of the sn-1 fatty acid of phosphatidylcholine to retinol bound to a cellular retinol-binding protein. In the present study we have cloned mouse and rat liver LRAT cDNA
Reza Zolfaghari, A. Catharine Ross
doaj   +1 more source

The compositional and evolutionary logic of metabolism

, 2012
Metabolism displays striking and robust regularities in the forms of modularity and hierarchy, whose composition may be compactly described. This renders metabolic architecture comprehensible as a system, and suggests the order in which layers of that ...
Alberts B, Andreini C, Balche W E, Barker H A, Benner S A, Berge C, Braakman R, Brazelton W J, Buss L W, Collins M D, Copley S D, Dagley S, Darwin C, de Duve C, Doyle J, Eric Smith, Erwin D H, Feist A M, Fenchel T, Fisher R A, Fry I, Gerhart J, Gesteland R F, Gould S J, Gray H B, Guiral M, Haldane J B S, Kallen R G, Kauffman S, Kim J, Lengeler J W, Ljungdahl L, MacKenzie R E, Martin W, Massey L K, Metzler D E, Morowitz H J, Morowitz H J, Morowitz H J, Nelson D L, Nitscke W, Odling-Smee F J, Oparin A I, Petsko G A, Puigbo P, Ragsdale S, Ragsdale S W, Rankama K, Razin S, Redfield A C, Redfield A C, Rogier Braakman, Russell M J, Schrödinger E, Schuster P, Segré D, Shapiro R, Simon H A, Simon H A, Smith E, Srinivasan V, Srinivasan V, Sterner R W, Stryer L, Szent-Gyorgyi A, Tazuya K, Utter M F, Vogels G D, von Wettstein D, Vorholt J A, Waber L J, Wald G, Wilson E B, Wächtershäuser G, Yarus M, Yi L   +75 more
core   +1 more source