Results 11 to 20 of about 538,895 (285)
Integrating experimental data with molecular simulations to investigate RNA structural dynamics [PDF]
Curr. Opin. Struct. Biol. 78, 102503 (2023), 2022 Conformational dynamics is crucial for ribonucleic acid (RNA) function. Techniques such as nuclear magnetic resonance, cryo-electron microscopy, small- and wide-angle X-ray scattering, chemical probing, single-molecule F\"orster resonance energy transfer or even thermal or mechanical denaturation experiments probe RNA dynamics at different time and ...
arxiv +1 more source
Pharmaceutics, 2021 Extracellular vesicles (EVs) are 50–1000 nm vesicles secreted by virtually any cell type in the body. They are expected to transfer information from one cell or tissue to another in a short- or long-distance way. RNA-based transfer of information via EVs
Max Piffoux +3 more
doaj +1 more source
A novel mistranslating tRNA model in Drosophila melanogaster has diverse, sexually dimorphic effects
G3: Genes, Genomes, Genetics, 2022 Transfer RNAs (tRNAs) are the adaptor molecules required for reading the genetic code and producing proteins. Transfer RNA variants can lead to genome-wide mistranslation, the misincorporation of amino acids not specified by the standard genetic code ...
Joshua R Isaacson +6 more
doaj +1 more source
Magnesium Contact Ions Stabilize the Tertiary Structure of Transfer RNA: Electrostatics Mapped by Two-Dimensional Infrared Spectra and Theoretical Simulations [PDF]
J. Phys. Chem. B 2021, 125, 740-747, 2021 Ions interacting with hydrated RNA play a central role in defining its secondary and tertiary structure. While spatial arrangements of ions, water molecules, and phosphate groups have been inferred from X-ray studies, the role of electrostatic and other noncovalent interactions in stabilizing compact folded RNA structures is not fully understood at the
arxiv +1 more source
The central dogma of biological homochirality: How does chiral information propagate in a prebiotic network? [PDF]
J. Chem. Phys. 159, 061102 (2023), 2023 Biological systems are homochiral, raising the question of how a racemic mixture of prebiotically synthesized biomolecules could attain a homochiral state at the network level. Based on our recent results, we aim to address a related question of how chiral information might have flowed in a prebiotic network. Utilizing the crystallization properties of
arxiv +1 more source
Tissue-specific differences in human transfer RNA expression. [PDF]
PLoS Genetics, 2006 Over 450 transfer RNA (tRNA) genes have been annotated in the human genome. Reliable quantitation of tRNA levels in human samples using microarray methods presents a technical challenge.
Kimberly A Dittmar +2 more
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Exploration of Targeted Anti-tumor Therapy, 2023 Aim: Recently, a tumor cell-platelet interaction was identified in different tumor entities, resulting in a transfer of tumor-derived RNA into platelets, named further “tumor-educated platelets (TEP)”.
Lisa T. Huber +9 more
doaj +1 more source
Mitochondrial DNA. Part B. Resources, 2021 The current study describes the complete mitochondrial genome (mitogenome) of an egg parasitoid wasp, Telenomus remus Nixon 1937. This mitogenome is 16,014 bp in length, consisting of 37 typical coding genes (13 protein-coding genes, 22 transfer RNA ...
Weiwei Li, Yunfei Wu, Bin Chen
doaj +1 more source
Characterization of Circulating Transfer RNA-Derived RNA Fragments in Cattle
Frontiers in Genetics, 2015 The objective was to characterize naturally occurring circulating transfer RNA-derived RNA Fragments (tRFs) in cattle. Serum from eight clinically normal adult dairy cows was collected, and small non-coding RNAs were extracted immediately after ...
Eduardo eCasas +2 more
doaj +1 more source
Nature Communications, 2020 Extracellular vesicles (EV) facilitate intercellular transfer of biological material including RNA, but the regulatory mechanisms for their formation and transfer are incompletely known.
Olivier G. de Jong +13 more
doaj +1 more source