Results 11 to 20 of about 538,024 (260)

Tissue-specific differences in human transfer RNA expression. [PDF]

open access: yesPLoS Genetics, 2006
Over 450 transfer RNA (tRNA) genes have been annotated in the human genome. Reliable quantitation of tRNA levels in human samples using microarray methods presents a technical challenge.
Kimberly A Dittmar   +2 more
doaj   +1 more source

Liquid biopsy: an examination of platelet RNA obtained from head and neck squamous cell carcinoma patients for predictive molecular tumor markers

open access: yesExploration of Targeted Anti-tumor Therapy, 2023
Aim: Recently, a tumor cell-platelet interaction was identified in different tumor entities, resulting in a transfer of tumor-derived RNA into platelets, named further “tumor-educated platelets (TEP)”.
Lisa T. Huber   +9 more
doaj   +1 more source

Transfer RNA and human disease

open access: yesFrontiers in Genetics, 2014
Pathological mutations in tRNA genes and tRNA processing enzymes are numerous and result in very complicated clinical phenotypes. Mitochondrial tRNA (mt-tRNA) genes are hotspots for pathological mutations and over 200 mt-tRNA mutations have been linked ...
Jamie A Abbott   +2 more
doaj   +1 more source

Novel gene rearrangement in the complete mitochondrial genome of Telenomus remus (Hymenoptera: Scelionidae)

open access: yesMitochondrial DNA. Part B. Resources, 2021
The current study describes the complete mitochondrial genome (mitogenome) of an egg parasitoid wasp, Telenomus remus Nixon 1937. This mitogenome is 16,014 bp in length, consisting of 37 typical coding genes (13 protein-coding genes, 22 transfer RNA ...
Weiwei Li, Yunfei Wu, Bin Chen
doaj   +1 more source

The abundance of a transfer RNA-derived RNA fragment small RNA subpopulation is enriched in cauda spermatozoa [PDF]

open access: yesExRNA, 2020
The small RNA (sRNA) landscape of mammalian spermatozoa is considerably altered as these gametic cells migrate through the segment specific microenvironments of the epididymis.
Simone J. Stanger   +6 more
doaj   +1 more source

Characterization of Circulating Transfer RNA-Derived RNA Fragments in Cattle

open access: yesFrontiers in Genetics, 2015
The objective was to characterize naturally occurring circulating transfer RNA-derived RNA Fragments (tRFs) in cattle. Serum from eight clinically normal adult dairy cows was collected, and small non-coding RNAs were extracted immediately after ...
Eduardo eCasas   +2 more
doaj   +1 more source

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

open access: yesNature Communications, 2020
Extracellular vesicles (EV) facilitate intercellular transfer of biological material including RNA, but the regulatory mechanisms for their formation and transfer are incompletely known.
Olivier G. de Jong   +13 more
doaj   +1 more source

Transfer RNA-derived small RNA: an emerging small non-coding RNA with key roles in cancer

open access: yesExperimental Hematology & Oncology, 2022
Transfer RNAs (tRNAs) promote protein translation by binding to the corresponding amino acids and transporting them to the ribosome, which is essential in protein translation.
Xinliang Gu   +5 more
doaj   +1 more source

ER Membrane Contact Sites: Key Platforms for Biogenesis of RNA-Containing Extracellular Vesicles

open access: yesContact, 2022
The mechanisms by which cytoplasmic cargoes such as RNAs are incorporated into extracellular vesicles (EVs) are poorly understood. In a recent article published in Developmental Cell, we describe a novel function of endoplasmic reticulum membrane contact
Bahnisikha Barman   +2 more
doaj   +1 more source

Highly Sensitive Northern Hybridization Using a Rapid Protocol for Downward Alkaline Blotting of RNA

open access: yesBioTechniques, 1998
A simple and fast RNA gel blot procedureis described that uses 50 mM NaOH tosimultaneously transfer and fix RNA to apositively charged nylon membrane. TheRNA is transferred in a downward direction,and transfer is routinely completedwithin 2.5 h.
Ivan L. Ingelbrecht   +2 more
doaj   +1 more source

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