Results 21 to 30 of about 5,035,452 (301)

Deep transfer learning of cancer drug responses by integrating bulk and single-cell RNA-seq data

Nature Communications, 2022
Drug screening data from massive bulk gene expression databases can be analyzed to determine the optimal clinical application of cancer drugs. The growing amount of single-cell RNA sequencing (scRNA-seq) data also provides insights into improving ...
Junyi Chen, Xiaoying Wang, A. Ma, Qi-En Wang, Bingqiang Liu, Lang Li, Dong Xu, Qin Ma   +7 more
semanticscholar   +1 more source

Exogenous RNA as a Regulatory Signal during a Plant’s Interaction with the Biotic Environment: An Evolutionary Perspective and Future Applications in Agriculture

Plants, 2021
Environmental RNAi (eRNAi) is a sequence-specific regulation of endogenous gene expression in a responsive organism by exogenous RNA. While exogenous RNA transfer between organisms of different kingdoms of life have been unambiguously identified in ...
Sergey Ivashuta, Alberto Iandolino, Greg Watson   +2 more
doaj   +1 more source

Myosin-Va-dependent cell-to-cell transfer of RNA from Schwann cells to axons. [PDF]

PLoS ONE, 2013
To better understand the role of protein synthesis in axons, we have identified the source of a portion of axonal RNA. We show that proximal segments of transected sciatic nerves accumulate newly-synthesized RNA in axons.
José R Sotelo, Lucía Canclini, Alejandra Kun, José R Sotelo-Silveira, Lei Xu, Horst Wallrabe, Aldo Calliari, Gonzalo Rosso, Karina Cal, John A Mercer   +9 more
doaj   +1 more source

Thinking Quantitatively of RNA-Based Information Transfer via Extracellular Vesicles: Lessons to Learn for the Design of RNA-Loaded EVs

Pharmaceutics, 2021
Extracellular vesicles (EVs) are 50–1000 nm vesicles secreted by virtually any cell type in the body. They are expected to transfer information from one cell or tissue to another in a short- or long-distance way. RNA-based transfer of information via EVs
Max Piffoux, Jeanne Volatron, Amanda K. A. Silva, Florence Gazeau   +3 more
doaj   +1 more source

A novel mistranslating tRNA model in Drosophila melanogaster has diverse, sexually dimorphic effects

G3: Genes, Genomes, Genetics, 2022
Transfer RNAs (tRNAs) are the adaptor molecules required for reading the genetic code and producing proteins. Transfer RNA variants can lead to genome-wide mistranslation, the misincorporation of amino acids not specified by the standard genetic code ...
Joshua R Isaacson, Matthew D Berg, Brendan Charles, Jessica Jagiello, Judit Villén, Christopher J Brandl, Amanda J Moehring   +6 more
doaj   +1 more source

Tissue-specific differences in human transfer RNA expression. [PDF]

PLoS Genetics, 2006
Over 450 transfer RNA (tRNA) genes have been annotated in the human genome. Reliable quantitation of tRNA levels in human samples using microarray methods presents a technical challenge.
Kimberly A Dittmar, Jeffrey M Goodenbour, Tao Pan   +2 more
doaj   +1 more source

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes. [PDF]

, 2017
RNA is secreted from cells enclosed within extracellular vesicles (EVs). Defining the RNA composition of EVs is challenging due to their coisolation with contaminants, lack of knowledge of the mechanisms of RNA sorting into EVs, and limitations of ...
Lambowitz, Alan M, Nottingham, Ryan M, Qin, Yidan, Schekman, Randy, Shurtleff, Matthew J, Temoche-Diaz, Morayma M, Yao, Jun   +6 more
core   +1 more source

Liquid biopsy: an examination of platelet RNA obtained from head and neck squamous cell carcinoma patients for predictive molecular tumor markers

Exploration of Targeted Anti-tumor Therapy, 2023
Aim: Recently, a tumor cell-platelet interaction was identified in different tumor entities, resulting in a transfer of tumor-derived RNA into platelets, named further “tumor-educated platelets (TEP)”.
Lisa T. Huber, Johann M. Kraus, Jasmin Ezić, Amin Wanli, Marco Groth, Simon Laban, Thomas K. Hoffmann, Barbara Wollenberg, Hans A. Kestler, Cornelia Brunner   +9 more
doaj   +1 more source

Structural insights into RNA processing by the human RISC-loading complex. [PDF]

, 2009
Targeted gene silencing by RNA interference (RNAi) requires loading of a short guide RNA (small interfering RNA (siRNA) or microRNA (miRNA)) onto an Argonaute protein to form the functional center of an RNA-induced silencing complex (RISC).
AD Haase, B Kastner, Bunpote Siridechadilok, C Matranga, Cameron Noland, David W Taylor, DS Schwarz, E Bernstein, E Ma, EF Pettersen, Enbo Ma, Eva Nogales, F Herzog, FV Rivas, H Gao, Hong-Wei Wang, IJ MacRae, IJ MacRae, IJ MacRae, JB Preall, Jennifer A Doudna, JJ Song, Karin Felderer, KH Kok, M Högbom, M Radermacher, M van Heel, PA Penczek, SH Scheres, SJ Ludtke, T Sasaki, TA Rand, TM Rana, TP Chendrimada, W Wriggers, Y Lee, Y Tomari, Y Tomari, Y Wang, Y Wang, YR Yuan, YR Yuan   +41 more
core   +2 more sources

Transfer RNA and human disease

Frontiers in Genetics, 2014
Pathological mutations in tRNA genes and tRNA processing enzymes are numerous and result in very complicated clinical phenotypes. Mitochondrial tRNA (mt-tRNA) genes are hotspots for pathological mutations and over 200 mt-tRNA mutations have been linked ...
Jamie A Abbott, Chris S Francklyn, Susan M Robey-Bond   +2 more
doaj   +1 more source