RNA compaction and iterative scanning for small RNA targets by the Hfq chaperone
Nature CommunicationsRNA-guided enzymes must quickly search a vast sequence space for their targets. This search is aided by chaperones such as Hfq, a protein that mediates regulation by bacterial small RNAs (sRNAs).
Ewelina M. Małecka, Sarah A. Woodson
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Mapping Current Studies of tRNA Fragments onto Disease Landscape
BiomoleculesTransfer-RNA-derived fragments (tRFs) are a relatively recently discovered class of non-coding RNAs derived from both precursor and mature transfer RNAs (tRNAs).
Sathyanarayanan Vaidhyanathan +16 more
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Transfer RNA comes of age [PDF]
RNA, 2015 The year the journal RNA was founded was slated by some in scientific publishing to be the year that one particular type of RNA's run in the spotlight would end. In 1995 I had recently started as a post-doc with Dieter Soll at Yale when he came into the lab to solemnly inform us all that an editor at a certain (S)cience journal had just told him “we ...
openaire +4 more sources
On-chip automation of cell-free protein synthesis: new opportunities due to a novel reaction mode [PDF]
, 2016 Many pharmaceuticals are proteins or their development is based on proteins. Cell-free protein synthesis (CFPS) is an innovative alternative to conventional cell based systems which enables the production of proteins with complex and even new ...
Bergmeister, Merlin +8 more
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FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
The complete plastid genome of a marine microalgae Cryptophyceae sp. CCMP2293 (Cryptophyta)
Mitochondrial DNA. Part B. Resources, 2019 In this study, we present the complete plastid genome of Cryptophyceae sp. CCMP2293. The circular genome is 139,208 bp in length and contains 142 protein-coding genes (PCGs), 30 transfer RNA (tRNA) genes, 6 ribosome RNA (rRNA) genes, and 1 transfer ...
Kuipeng Xu, Shunxin Hu, Xianghai Tang
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A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS. [PDF]
, 2019 Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA).
Blanchard, Scott C +15 more
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Small RNA-based feedforward loop with AND-gate logic regulates extrachromosomal DNA transfer in Salmonella [PDF]
, 2015 Horizontal gene transfer via plasmid conjugation is a major driving force in microbial evolution but constitutes a complex process that requires synchronization with the physiological state of the host bacteria.
Casadesús Pursals, Josep +3 more
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Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
Use of RNA secondary structure for evolutionary relationships : investigating RNase P and RNase MRP : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University, New Zealand [PDF]
, 1998 Bioinformatics is applied here to examine whether RNA secondary structure data can reflect distant evolutionary relationships. This is important when there is little confidence in sequence data such as when looking at the evolution of RNase MRP (MRP ...
Collins, Lesley Joan
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