Results 251 to 260 of about 158,881 (313)

Recent Progress in Sequence Optimization of mRNA Vaccine: Biological Mechanism, Quantitative Metrics, and Computational Model. [PDF]

Bioinform Biol Insights
Wang Y, Cai Y, Wu Z, Zhang J, Turtle L, Meng J.   +5 more
europepmc   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, Volume 13, Issue 34, 19 June 2026.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Targeted long-read RNA sequencing for rare disease diagnosis and variant interpretation. [PDF]

Sci Adv
Wang R, Wang F, DeBruyne N, Ji X, Engelhardt NM, Park JJ, Notaro A, Gaerlan S, Park R, Schultz MJ, Clever S, McCormick EM, Keith K, Ng BG, Kadash-Edmondson KE, Freeze HH, Lam CT, Morava E, Helbig I, Falk MJ, Ganetzky RD, Edmondson AC, Lin L, Xing Y.   +23 more
europepmc   +1 more source

Directed Evolution Improves the Catalytic Efficiency of APEX2‐Mediated Proximity‐Dependent RNA Labeling

Advanced Science, Volume 13, Issue 32, 9 June 2026.
ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley   +1 more source

Iron and peroxide regulation of the PrrF sRNAs and a conserved ferritin family protein in <i>Pseudomonas aeruginosa</i> and <i>Pseudomonas fluorescens</i>. [PDF]

J Bacteriol
Ouattara KO, Chourashi R, Oglesby AG.
europepmc   +1 more source

Allele specific expression in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Allele‐specific expression (ASE), preferential expression of one allele at a heterozygous locus, is implicated in various brain diseases but remains largely uncharacterized in Alzheimer's disease (AD). METHODS We performed a genome‐wide characterization of ASE variants across seven brain regions of 2,231 AD and Control patients ...
Zishan Wang, Delowar Hossain, Judy Jiaru Wang, Varun R. Subramaniam, Bin Zhang, Minghui Wang, Kuan‐lin Huang   +6 more
wiley   +1 more source

<i>Mettl5</i> coordinates protein production and degradation of PERIOD to regulate sleep in <i>Drosophila</i>. [PDF]

Elife
Wu X, Yang X, Fu T, Rong Y, Du J.
europepmc   +1 more source

All You Can Eat Yeast: Substituting Hexose Transporters With AtSWEET7 Alleviates Glucose Repression, Enabling Simultaneous Utilization of Sugars in Renewable Feedstocks

Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1518-1530, June 2026.
ABSTRACT Yeast sugar transporters have highly evolved for preferential glucose transport, a significant roadblock for utilizing non‐glucose sugars in renewable feedstocks such as lignocellulosic biomass. To enable simultaneous transport of multiple sugars, native hexose transporters were replaced by SWEET7p from Arabidopsis thaliana in engineered ...
Nurzhan Kuanyshev, Degaulle Dai, Jungyeon Kim, Nam Kyu Kang, Ming‐Hsun Cheng, Vijay Singh, Yong‐Su Jin   +6 more
wiley   +1 more source

Maize Anther Development Involves Translated Open Reading Frames From 3' Untranslated Regions. [PDF]

Adv Sci (Weinh)
Wang C, Wu Y, Wang S, Liu H, Jiang S, Han Y, Wu L, Zhang T, Zhang M.   +8 more
europepmc   +1 more source

Optimizing Pichia Pastoris Cell‐Free Protein Synthesis to Improve Economics

Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1708-1720, June 2026.
ABSTRACT Cell‐free protein synthesis (CFPS) is a powerful and versatile platform that supports a wide range of applications, from fundamental studies of the genetic code to scalable and rapid protein production. The recently developed Pichia pastoris CFPS combines advantages of both prokaryotic and eukaryotic systems, including a rapid growth rate ...
Rui Wu, Igor Koop, Gavin Murugan, Thagshanen Thillairajah, Karen M. Polizzi   +4 more
wiley   +1 more source